A5012714200- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Flavonoids in Medical Research
- Alzheimer's disease research and treatments
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Toxicity Studies
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Phytochemicals and Medicinal Plants
- Vitamin C and Antioxidants Research
- Stress Responses and Cortisol
Treventis (United States)
2024
Treventis (Canada)
2020-2023
University Health Network
2021-2023
Krembil Research Institute
2021-2023
Advanced Numerical Research and Analysis Group
2021
Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors use human cancers now focus of widespread research development efforts. In this study, we report the structure-based design 2-(5-imidazolyl)indole derivatives, series novel IDO1 which have been designed synthesized based on our previous study using N1-substituted 5-indoleimidazoles. Among these, identified one with strong...
Indoleamine 2,3-dioxygenase (IDO1) inhibition is a promising target as an Alzheimer's disease (AD) Disease-modifying therapy capable of downregulating immunopathic neuroinflammatory processes.