A5103273999- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Crystallography and molecular interactions
- Catalytic Alkyne Reactions
- SARS-CoV-2 and COVID-19 Research
- Catalysis for Biomass Conversion
- Synthetic Organic Chemistry Methods
- Tryptophan and brain disorders
- Catalytic C–H Functionalization Methods
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Aluminum Alloy Microstructure Properties
- High Temperature Alloys and Creep
- Microstructure and Mechanical Properties of Steels
- Axial and Atropisomeric Chirality Synthesis
- Zeolite Catalysis and Synthesis
- Synthesis and Catalytic Reactions
- Pharmacological Receptor Mechanisms and Effects
- Mesoporous Materials and Catalysis
- Thermography and Photoacoustic Techniques
- Transition Metal Oxide Nanomaterials
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Synthesis of Indole Derivatives
University of the Basque Country
1997-2023
Krembil Research Institute
2020-2022
University Health Network
2020-2022
Institut Català d'Investigació Química
2021
Krembil Foundation
2020
University of Córdoba
1993-1995
BINOL-based N-trifluoromethanesulfonyl phosphoramides catalyze the enantioselective (4+3) cycloaddition between furans and oxyallyl cations, latter being generated in situ by oxidation of allenamides. The chiral organic phosphoramide counteranion is proposed to engage activation cation intermediate through cooperative hydrogen-bonding ion-pairing interactions, enabling an efficient chirality transfer that provide final adducts with high diastereo- enantioselectivities. Remarkably, reaction...
Abstract We have developed a procedure for the stereoselective and diastereodivergent synthesis of densely functionalised cyclohexanes containing four stereocentres through an asymmetric Michael‐initiated ring closure (MIRC) cascade reaction employing hydrogen‐bond catalysis, which is able to prepare adducts with different absolute configurations starting from same materials. The overall process involves highly diastereo‐ enantioselective Michael/Henry between wide range nitroalkenes...
The novel coronavirus SARS-CoV-2 has become a global health concern. morbidity and mortality of the potentially lethal infection caused by this virus arise from initial viral subsequent host inflammatory response. latter may lead to excessive release pro-inflammatory cytokines, IL-6 IL-8, as well TNF-α ultimately culminating in hypercytokinemia ("cytokine storm"). To address immuno-inflammatory pathogenesis, multiple clinical trials have been proposed evaluate anti-inflammatory biologic...
Highly enantioenriched, chromatographically-stable secondary allyl boronates featuring a 1,1,2,2-tetraethyl-1,2-ethanediol fragment (Epin) were obtained by kinetic resolution of their racemic mixtures. The Epin group at boron considerably improved stability allowing them to be readily isolated chromatography on silica. resolved reagents applied in stereoselective synthesis homoallylic amines with an internal double bond employing unprotected imines formed situ from aldehydes and ammonia....
Abstract BINOL‐based N‐trifluoromethanesulfonyl phosphoramides catalyze the enantioselective (4+3) cycloaddition between furans and oxyallyl cations, latter being generated in situ by oxidation of allenamides. The chiral organic phosphoramide counteranion is proposed to engage activation cation intermediate through cooperative hydrogen‐bonding ion‐pairing interactions, enabling an efficient chirality transfer that provide final adducts with high diastereo‐ enantioselectivities. Remarkably,...
AbstractAbstractLow alloy AISI 4130 steel has been bonded to an Incoloy 825 and a Duplex 2205 stainless by industrial hot extrusion process, the final product being seamless clad tube, with internal lining of these corrosion resistant alloys. The microstructures as processed products have analysed using optical metallography scanning (SEM) transmission (STEM) electron microscopy. interdiffusion various elements through interface determined microanalysis both in SEM STEM. For combination...
Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors use human cancers now focus of widespread research development efforts. In this study, we report the structure-based design 2-(5-imidazolyl)indole derivatives, series novel IDO1 which have been designed synthesized based on our previous study using N1-substituted 5-indoleimidazoles. Among these, identified one with strong...
The design of potent indoleamine 2,3-dioxygenase 1 (IDO1) enzyme inhibitors targeting immunopathic neuroinflammation has emerged as an area interest for the treatment Alzheimer's disease (AD); additionally, recent findings on clinical benefits antibodies preventing β-amyloid (Aβ) aggregation have renewed efforts to discover small molecule anti-aggregants proteopathic protein misfolding. Exploiting endogenous tryptophan-like scaffold, we describe and synthesis small-molecule both processes,...
Abstract A one‐pot approach for the title reactions is also presented [reaction of (VII)].
Abstract The mechanism of the enantioselective (4+3) cycloaddition between furan derivatives and oxyallylcations, which are generated from corresponding oxiranes through in situ oxidation allenamides, has been studied using DFT methods. research revealed that, under acid‐catalysis by a chiral non‐racemic phosphoramide, epoxide ring‐opening proceeds without any energy barrier, while rate‐limiting step is electrophilic attack intermediate enaminium ion on ring. reaction exhibits low barriers...
AbstractAbstractLow alloy AISI 4130 steel has been bonded to an Incoloy 825 and a Duplex 2205 stainless by industrial hot extrusion process, the final product being seamless clad tube, with internal lining of these corrosion resistant alloys. The microstructures as processed products have analysed using optical metallography scanning (SEM) transmission (STEM) electron microscopy. interdiffusion various elements through interface determined microanalysis both in SEM STEM. For combination...