A5000343296- Microbial Natural Products and Biosynthesis
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- Nanoparticles: synthesis and applications
- Peptidase Inhibition and Analysis
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Multicomponent Synthesis of Heterocycles
- Nanomaterials for catalytic reactions
- Cancer, Lipids, and Metabolism
- Supramolecular Self-Assembly in Materials
- Endoplasmic Reticulum Stress and Disease
- Quinazolinone synthesis and applications
- Nutritional Studies and Diet
- Biomarkers in Disease Mechanisms
- Nanoplatforms for cancer theranostics
- Seaweed-derived Bioactive Compounds
- Colorectal Cancer Surgical Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Graphene and Nanomaterials Applications
- Genetic factors in colorectal cancer
- Synthesis of Tetrazole Derivatives
- Machine Learning in Bioinformatics
University of Palermo
2017-2024
Institute of Cell Biology and Neurobiology
2017
// Miriam Buttacavoli 1, * , Nadia Ninfa Albanese Gianluca Di Cara 2 Rosa Alduina 1 Claudia Faleri 3 Michele Gallo 4 Giuseppe Pizzolanti 5, 6 Salvatore Feo Franco Baldi and Patrizia Cancemi 2, Department of Biological Chemical Pharmaceutical Sciences Technologies (STEBICEF), University Palermo, Italy Center Experimental Oncobiology (C.OB.S.), La Maddalena Hospital III Level Oncological Dept., Life Science, Siena, Molecular Science Nanosystems, Cà Foscari Venice, 5 Biomedical Internal...
Colorectal cancer (CRC) develops by genetic and epigenetic alterations. However, the molecular mechanisms underlying metastatic dissemination remain unclear could benefit from multi-omics investigations of specific protein families. Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in ECM remodeling processing bioactive molecules. Increased MMP expression promotes hallmarks tumor progression, including angiogenesis, invasion, metastasis, is correlated with a shortened...
Breast cancer is a complex and heterogeneous disease: Several molecular alterations cause cell proliferation the acquisition of an invasive phenotype. Extracellular matrix (ECM) considered essential for sustaining tumor growth metalloproteinases (MMPs) have been identified as drivers many aspects Mounting evidence indicates that both α-enolase (ENO1) Myc promoter-binding protein-1 (MBP-1) also played pivotal roles in tumorigenesis, although antagonists. ENO1 involved growth, hypoxia...
: Pyrrolomycins (PMs) are polyhalogenated antibiotics known as powerful biologically active compounds, yet featuring high cytotoxicity. The present study reports the antibacterial and antitumoral properties of new chemically synthesized PMs, where three positions pyrrolic nucleus were replaced by nitro groups, aiming to reduce their cytotoxicity while maintaining or even enhancing biological activity. Indeed, presence substituent in diverse pyrrole determined an improvement minimal...
// Patrizia Cancemi 1, 2, 3 , Miriam Buttacavoli 1 Gianluca Di Cara 2 Nadia Ninfa Albanese Serena Bivona Ida Pucci-Minafra and Salvatore Feo 3, 4 Department of Biological Chemical Pharmaceutical Sciences Technologies (STEBICEF), University Palermo, Italy Center Experimental Oncobiology (C.OB.S.), La Maddalena Hospital III Level Oncological Dept., Advanced Network (ATeN), Institute Biomedicine Molecular Immunology, CNR, Correspondence to: Cancemi, email: patrizia.cancemi@unipa.it Keywords:...
Anti-microbial and anti-proliferative activities of diimidazolium salts have been analyzed as a function the main changes in their structural features.
Heat shock proteins (HSPs) are a well-characterized molecular chaperones protein family, classified into six major families, according to their size. A wide range of tumors have been shown express atypical levels one or more HSPs, suggesting that they could be used as biomarkers. However, the collective role and possible coordination HSP members, well prognostic significance functional implications deregulated expression in breast cancer (BC) poorly investigated. Here, we systematic...
Colon cancer is an aggressive tumor form with a poor prognosis. This study reports comparative proteomic analysis performed by using two-dimensional differential in-gel electrophoresis (2D-DIGE) between 26 pooled colon surgical tissues and adjacent non-tumoral tissues, to identify potential target proteins correlated carcinogenesis. The DAVID functional classification tool revealed that most of the differentially regulated proteins, acting both intracellularly extracellularly, concur across...
Pyrrolomycins (PMs) are a family of naturally occurring antibiotic agents, isolated from the fermentation broth Actinosporangium and Streptomyces species. Pursuing our studies on pyrrolomycins, we performed total synthesis F-series pyrrolomycins (1-4) by microwave-assisted (MAOS), thus obtaining title compounds in excellent yields (63-69%). Considering that there is no evidence so far anticancer effect this class compounds, investigated PMs for their antiproliferative activity against HCT116...
With the aim to obtain targeted chemotherapeutic agents, imidazolium and ammonium-based folate salts were synthesized. Their photophysical behavior was investigated both in buffer buffer/DMSO solution as well solid phase, performing UV-vis fluorescence investigations. Properties of aggregates also analyzed by dynamic light scattering. Gelation ability biocompatible solvents, gel phases obtained characterized determining critical gelation concentrations gel-solution transition temperatures....