The kidney is the most damaged organ in asphyxiated full-term infants. Experiments rabbits and rats have shown that renal adenosine acts as a vasoconstrictive metabolite after hypoxemia and/or ischemia, contributing to fall glomerular filtration rate (GFR) fraction. Vasoconstriction produced by can be inhibited nonspecific receptor antagonist, theophylline. Gouyon Guignard performed studies newborn adult subjected normocapnic hypoxemia. Their results clearly showed hypoxemia-induced drop GFR...

Ferraris JR, Argibay PF, Costa L, Jimenez G, Coccia PA, Ghezzi LFR, V, Belloso WH, Redal MA, Larriba JM. Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation: Age dependency pharmacological interaction with steroids. Pediatr Transplantation 2011: 15: 525–532. © 2011 John Wiley & Sons A/S. Abstract: TAC, MMF MP are used in pediatric kidney tx. The cytochrome P450 (CYP)3A5 enzyme appears to play a role TAC metabolism. aims this study...

Summary Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical alternative pathways complement during phase Shiga toxin-associated HUS performing a prospective study 18 patients 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb SC5b-9 levels. levels were increased significantly in all at admission compared end-stage disease controls, but higher presenting with oliguria...

Background. Chronic rejection is the leading cause of graft failure.Both nonimmunological and immunological mechanisms contribute to this pathology. Methods. We studied changes in kidney function, mixed lymphocyte culture, cell-mediated lympholysis, serum HLA class Ι antigens, cytotoxic antibodies, population before after 6 months follow-up 22 pediatric renal transplanted patients. The immunosuppressive protocol used was: cyclosporine, azathioprine, corticosteroids. Eight patients...

The effects of chronic renal failure on the hypothalamic-pituitary-ovarian axis in 25 girls, aged 9.1 to 20.9 years (mean 13.8) were studied. Twelve patients conservative treatment (group A) had serum creatinine values between 176.8 and 1502.8 mumol/l; 9 haemodialysis B); 12 received a transplant C). Tanner stage breast development was delayed relative chronological age 5 out 18 patients. Serum oestradiol normal or low when related pubertal stages all groups. LH elevated group A B patients,...

Abstract: While 24‐h ambulatory blood pressure monitoring (ABPM) is an established tool for antihypertensive therapy in adults, data children are scarce. We retrospectively analysed whether office (BP) reliable the diagnosis of BP control 26 treated hypertensive paediatric renal transplants. Controlled was defined as mean three replicate systolic and diastolic recordings less than or equal to 95th age‐, sex‐ height‐matched percentile on three‐outpatient visits closest ABPM. ABPM daytime...

Nitric oxide (NO) contributes to maintaining normal cardiovascular and renal function. This bioactive signalling molecule is generally formed enzymatically by NO synthase in the vascular endothelium. bioactivity can also be attributed dietary intake of inorganic nitrate, which abundant our diet, especially green leafy vegetables beets. Ingested nitrate reduced nitrite oral commensal bacteria further systemically. Previous studies have shown that dialysis, means removing from body, reduce...

Background. Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection not been clarified. Methods. We studied changes kidney function, mixed lymphocyte culture, cell-mediated lympholysis, cytotoxic antibodies, population, and cytokine response before after the conversion from CsA Tac 14 pediatric rejection. (5.9±0.2...

The aim of this study was to the incidence chronic renal dysfunction in patients with more than 5 yr follow-up following liver transplantation and evaluate benefit decreasing cyclosporine A (CsA) dose combined mycophenolate mofetil (MMF) on function immune response these patients. Between 1988 1994, 60 children were transplanted, 86% survived >5 post-liver transplantation. Fourteen developed secondary CsA toxicity as evaluated by biopsy. In 11 decreased 40-90 mg/ml target levels MMF 600...

Twenty-four-hour ambulatory blood pressure monitoring (ABPM) has proven to have better reproducibility than office (BP) and is increasingly used for the study of hypertension in children adolescents. The aim our was assess 24-h BP profiles compare results measurements with ABPM stable liver transplant recipients transplanted before age 18 yr. performed 29 patients (nine males, 20 females), aged 3.9-24.8 yr (median 10.8 yr). investigation conducted 1.1-11.5 5.1 yr) following transplantation....

Abstract: MMF has been shown to decrease the incidence of acute rejection in children and adults at 1 3 yr. Other beneficial effects have more difficult demonstrate. Our open‐labeled study presents a 5‐yr data for patients graft survival, allograft function, growth MMF‐treated patients. The trial included 29 who were treated with combination cyclosporine methylprednisone. Patients compared preceding group AZA instead MMF. Patient survival rate 5 yr after transplantation 97 90% vs. 93 83% (p:...

Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopaenia and acute renal failure. The aim of this study was to investigate the levels oxidative stress (OS) during phase HUS.This prospective included 18 patients diagnosed with D + HUS, 6 age-matched healthy controls 29 children end-stage disease (ESRD) not caused HUS under regular haemodialysis. Plasma lipid peroxidation non-enzymatic antioxidant defences were measured as thiobarbituric acid-reactive...

We had previously reported that serum sex hormone binding-globulin (SHBG) decreases and non-SHBG-bound testosterone (T) free T increase significantly from infancy to late prepuberty in normal prepubertal children of both sexes. also shown an age-related delay these changes hypopituitary boys, which was reversed by GH treatment. Stunted growth delayed puberty are conspicuous features chronic renal failure (CRF). As another model development, SHBG fractions were determined 13 boys with CRF on...

We assessed the long-term rehabilitation and quality of life after kidney transplantation in 17 recipients transplants during their childhood who had reached 10 years or more grafting. found that all considered themselves to be good excellent health, 59% were completely satisfied with life. Ninety-four percent did not report any interference health family Only one recipient was unemployed, five have miss work (n=2) school (n=3) a few days year due status. Health seldom never interfered...