A5068264441- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Cannabis and Cannabinoid Research
- Reproductive Biology and Fertility
- COVID-19 Clinical Research Studies
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Prenatal Substance Exposure Effects
- Aldose Reductase and Taurine
- Marine and fisheries research
- Ichthyology and Marine Biology
- Coastal and Marine Management
- Coral and Marine Ecosystems Studies
- Coastal and Marine Dynamics
- Ethics and Legal Issues in Pediatric Healthcare
- Pregnancy and Medication Impact
- Developmental Biology and Gene Regulation
University of Lisbon
2022
Instituto Gulbenkian de Ciência
2021-2022
University Hospitals Coventry and Warwickshire NHS Trust
2018-2021
University of Warwick
2018-2021
National Health Service
2020-2021
Genomics (United Kingdom)
2021
Universidade do Porto
2016-2017
Rede de Química e Tecnologia
2016-2017
Stanford University
2013
During the implantation window, endometrium becomes poised to transition a pregnant state, process driven by differentiation of stromal cells into decidual (DC). Perturbations in this process, termed decidualization, leads breakdown feto-maternal interface and miscarriage, but underlying mechanisms are poorly understood. Here, we reconstructed pathway at single-cell level vitro demonstrate that first mount an acute stress response before emerging as DC or senescent (snDC). In absence immune...
Recurrent pregnancy loss (RPL) is associated with the of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment bone marrow-derived to sites tissue injury. Here, we evaluated effect inhibitor sitagliptin on eMSC in women RPL, determined impact decidualization, assessed feasibility a full-scale clinical trial.A double-blind, randomised, placebo-controlled trial aged 18 42 years history 3 or more miscarriages, regular menstrual cycles, no...
Abstract Pregnancy depends on the wholesale transformation of endometrium, a process driven by differentiation endometrial stromal cells (EnSC) into specialist decidual cells. Upon embryo implantation, impart tissue plasticity needed to accommodate rapidly growing conceptus and invading placenta, although underlying mechanisms are unclear. Here we characterize discrete population highly proliferative mesenchymal (hPMC) in midluteal human coinciding with window implantation. Single-cell...
Endocannabinoids (eCBs) are endogenous mediators that along with the cannabinoid receptors (CB1 and CB2), a membrane transporter metabolic enzymes form endocannabinoid system (ECS). Several eCBs have been discovered emphasis on anandamide (AEA). They involved in several biological processes such as energy balance, immune response reproduction. Decidualization occurs during secretory phase of human menstrual cycle, which involves proliferation differentiation endometrial stromal cells into...
Differentiation of endometrial fibroblasts into specialized decidual cells controls embryo implantation and transforms the cycling endometrium a semi-permanent, immune-protective matrix that accommodates placenta throughout pregnancy. This process starts during midluteal phase menstrual cycle with transformation perivascular (PVC) surrounding terminal spiral arterioles stromal (EnSC) underlying luminal epithelium. Decidualization involves extensive cellular reprogramming acquisition...
Background Adults are being vaccinated against SARS-CoV-2 worldwide, but the longitudinal protection of these vaccines is uncertain, given ongoing appearance variants. Children remain largely unvaccinated and susceptible to infection, with studies reporting that they actively transmit virus even when asymptomatic, thus affecting community. Methods We investigated if saliva an effective sample for detecting RNA antibodies in children, associated viral levels infectivity. For that, we used a...
Abstract Breakdown of the feto-maternal interface in early pregnancy causes miscarriage. The cycling endometrium becomes poised to transition a pregnant state during midluteal implantation window, coinciding with differentiation stromal cells into decidual (DC) and emergence senescent (snDC). Emerging evidence suggests that DC engage uterine natural killer eliminate their counterparts, thus enabling formation robust matrix pregnancy. To examine if failure constrain snDC peri-implantation...
Abstract Pregnancy depends on the wholesale transformation of endometrium, a process driven by differentiation endometrial stromal cells (EnSC) into specialist decidual cells. Upon embryo implantation, impart tissue plasticity needed to accommodate rapidly growing conceptus and invading placenta, although underlying mechanisms are unclear. Here we characterize discrete population highly proliferative mesenchymal (hPMC) in midluteal human coinciding with window implantation. Single-cell...
ABSTRACT Differentiation of endometrial fibroblasts into specialized decidual cells controls embryo implantation and transforms the cycling endometrium a semi-permanent, immune-protective matrix that accommodates placenta throughout pregnancy. This process starts during midluteal phase menstrual cycle with transformation perivascular (PVC) surrounding terminal spiral arterioles stromal (EnSC) underlying luminal epithelium. Decidualization involves extensive cellular reprogramming acquisition...
Structured abstract IMPORTANCE Adults are being vaccinated against SARS-CoV-2 worldwide, but the longitudinal protection of these vaccines is uncertain, given ongoing appearance variants. Children susceptible to infection, and some studies reported that they actively transmit virus even when asymptomatic, thus affecting community. Methods easily test infected children track carry in demand. OBJECTIVE To determine if saliva an effective sample for detecting RNA antibodies aged 10 years under,...
Background: Recurrent pregnancy loss (RPL) is associated with the of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment bone marrow-derived to sites tissue injury by preventing inactivation stromal cell-derived factor-1α, a potent chemoattractant.Aims: To assess effect inhibitor sitagliptin on eMSC in women RPL, evaluate impact decidualization, feasibility full-scale clinical trial.Methods: A double-blind, randomised,...