A5083995855- Endometriosis Research and Treatment
- Crustacean biology and ecology
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Aquaculture Nutrition and Growth
- Fish biology, ecology, and behavior
- Marine and fisheries research
- Coral and Marine Ecosystems Studies
- Minimally Invasive Surgical Techniques
- Pregnancy and preeclampsia studies
- Ovarian cancer diagnosis and treatment
- Gynecological conditions and treatments
- Insect symbiosis and bacterial influences
- Reproductive Biology and Fertility
- Invertebrate Immune Response Mechanisms
- Aquatic life and conservation
- Antimicrobial Peptides and Activities
- Mollusks and Parasites Studies
- Neurobiology and Insect Physiology Research
- Parasites and Host Interactions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Helminth infection and control
- Marine Bivalve and Aquaculture Studies
- Tropical and Extratropical Cyclones Research
- Gastrointestinal disorders and treatments
Juntendo University
2013-2024
University of Miyazaki
2024
Nagoya University
2024
Waseda University
2023
Soka Municipal Hospital
2018-2019
Japan Fisheries Research and Education Agency
2008-2018
Saitama Medical University
2017
Social Insurance Saitama Chuo Hospital
2017
University of Warwick
2013-2015
University Hospital Coventry
2012-2013
Menstruation drives cyclic activation of endometrial progenitor cells, tissue regeneration, and maturation stromal which differentiate into specialized decidual cells prior to during pregnancy. Aberrant responsiveness human (HESCs) deciduogenic cues is strongly associated with recurrent pregnancy loss (RPL), suggesting a defect in cellular maturation. MeDIP-seq analysis HESCs did not reveal gross perturbations CpG methylation RPL cultures, although quantitative differences were observed or...
Decidualization renders the endometrium transiently receptive to an implanting blastocyst although underlying mechanisms remain incompletely understood. Here we show that human endometrial stromal cells (HESCs) rapidly release IL-33, a key regulator of innate immune responses, upon decidualization. In parallel, differentiating HESCs upregulate IL-33 transmembrane receptor ST2L and other pro-inflammatory mediators before mounting profound anti-inflammatory response includes downregulation...
The endometrial perivascular microenvironment is rich in mesenchymal stem-like cells that express type 1 integral membrane protein Sushi domain containing 2 (SUSD2) but the role of these decidual transformation this tissue pregnancy unknown. We used an antibody directed against SUSD2 (W5C5) to isolate (W5C5(+)) and nonperivascular (W5C5(-)) fibroblasts from mid-luteal biopsies. show expression, hence ratio W5C5(+):W5C5(-) cells, changes culture depending on cell-cell contact activation Notch...
Abstract Pregnancy critically depends on the transformation of human endometrium into a decidual matrix that controls embryo implantation and placenta formation, process driven foremost by differentiation polarization endometrial stromal cells mature senescent cells. Perturbations in underpin spectrum prevalent reproductive disorders, including failure early pregnancy loss, emphasizing need for new therapeutic interventions. Resveratrol is naturally occurring polyphenol, widely used its...
Objectives The mechanisms of obesity associated reproductive complications remain poorly understood. Endometrial mesenchymal stem-cells are critical for cyclic renewal and uterine function. Recently, W5C5+ cells, with high clonogenicity, capable producing endometrial stroma in vivo, have been described. We sought to investigate the abundance cloning efficiency W5C5− cells relation Body Mass Index, age outcome. Design were purified from mid-luteal biopsies (n = 54) by magnetic bead separation...
Perinatal care in Japan has progressed rapidly recent decades, remarkably reducing maternal, perinatal and neonatal mortality rates. This is attributable not only to the sustained efforts dedication of past obstetricians midwives, but also collective results achieved by Society Obstetrics Gynecology healthcare administration, including research on advanced medical care, education, improvements establishing centers. Although maternal rate was steady decline until 2007 (3.1/100 000 births), it...
Vitamin D (VD) deficiency is associated with reproductive failure. However, the relationship between VD and maternal immunity remains unclear. We investigated clinical efficacy of in T-helper (Th) cytokines 276 infertile women examined for Th1 Th2 cells based on deficient, insufficient, sufficient serum 25-hydroxyvitamin D3 (25[OH]VD) levels (<12, 12–30, >30 ng/mL, respectively). Most had a low-level (87.3%). Immunological tests pre-/post-VD supplementation were performed patients who...
Differentiation of endometrial fibroblasts into specialized decidual cells controls embryo implantation and transforms the cycling endometrium a semi-permanent, immune-protective matrix that accommodates placenta throughout pregnancy. This process starts during midluteal phase menstrual cycle with transformation perivascular (PVC) surrounding terminal spiral arterioles stromal (EnSC) underlying luminal epithelium. Decidualization involves extensive cellular reprogramming acquisition...
1. A ribonuclease (RNase P) was isolated from porcine pancreas. The enzyme purified by means of ammonium sulfate fractionation, phenol extraction, DEAE-, Phospho- and CM-cellulose column chromatography about 850 fold. 2. Purified RNase P homogeneous in centrifugation (S=2.10). specific activity 70–85% [EC 2.7.7.16, ribonucleate pyrimidinenucleotido-2'-transferase (cyclizing)] under the conditions used for estimation. 3. very similar to that respect molecular weight, heat stability dependence...
Even though 95% of struma ovarii are benign, it is often overtreated because the difficulty to distinguish from malignancy. In this study, our aim was evaluate current state preoperative diagnosis and selection surgical procedure, improve diagnostic accuracy by retrospectively reviewing imaging findings.We reviewed clinical course characteristics 18 patients who were diagnosed postoperatively with ovarii, pathologically, at institution between 2015 2021.The diagnoses included benign ovarian...
The oral gonadotropin-releasing hormone antagonist relugolix, which temporarily stops menstruation, is used to treat heavy menstrual bleeding, pelvic pressure, and low back pain in women with uterine fibroids. Treatment can also help recover from hemoglobin levels possibly shrink the However, evidence of preoperative use relugolix before laparoscopic myomectomy limited. Nevertheless, treatment could reduce interoperative blood loss, decrease risk developing postoperative anemia, shorten...
Ontogenetic change in body density and shape of phyllosoma larvae was examined for the Japanese spiny lobster Panulirus japonicus (von Siebold, 1824) using laboratory-cultured specimens from hatching to final stage before metamorphosing puerulus stage. Phyllosomas have a unique form that is leaf-like dorso-ventrally compressed with several appendages, long planktotrophic life ocean. not found larval density, mean (1.097 g cm-3) greater than seawater (1.024 cm-3), indicating they must employ...
A 77-year-old woman with chronic iron deficiency anemia had a medical examination in May 2002. She was diagnosed as having anisakiasis after upper endoscopy of the antrum stomach, and worm removed. Three years later, an showed several worms first second portions duodenum, but there were no symptoms. Ten live removed using standard biopsy forceps identified by microscopic hookworm (Ancylostoma duodenale).
We investigated the effects of male and female body size on mating behavior spawning success Japanese spiny lobster Panulirus japonicus (von Siebold, 1824) under laboratory conditions in order to develop broodstock management techniques. The lobsters were divided into three body-size groups each sex based maximum sizes observed landings minimum at sexual maturity. Mating was by video recording 39 pairs nine combinations among large-, medium-, small-size sex. 21 pairs, 20 females laid eggs,...