A5009711341- Reproductive Biology and Fertility
- Tunneling and Rock Mechanics
- Geotechnical Engineering and Analysis
- Ovarian function and disorders
- Grouting, Rheology, and Soil Mechanics
- Reproductive System and Pregnancy
- Rock Mechanics and Modeling
- Endometriosis Research and Treatment
- Geotechnical Engineering and Underground Structures
- Assisted Reproductive Technology and Twin Pregnancy
- Geotechnical and Geomechanical Engineering
- Gynecological conditions and treatments
- Civil and Geotechnical Engineering Research
- Reproductive Health and Technologies
- Geomechanics and Mining Engineering
- Drilling and Well Engineering
- Sperm and Testicular Function
- Pregnancy and Medication Impact
- Structural Response to Dynamic Loads
- Landslides and related hazards
- Prenatal Screening and Diagnostics
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Geoscience and Mining Technology
- Ectopic Pregnancy Diagnosis and Management
Okayama University
2021-2025
University of Toyama
2025
Tokuyama (Japan)
2008-2024
Juntendo University
2023
University of Tsukuba
1997-2022
Kyoto University
1972-2015
Weatherford College
2009-2014
Kyushu University
2004-2013
National Institute of Technology, Hakodate College
2003-2009
National Center For Child Health and Development
2004-2009
We evaluated the clinical efficacy of immunosuppressive treatment with tacrolimus for repeated implantation failure (RIF) patients who have elevated in T helper (Th1)/Th2 cytokine producing cell ratios.This was a prospective cohort study RIF (n = 42) peripheral blood Th1 (CD4(+) /IFN-γ(+) )/Th2 /IL-4(+) ) ratios at Sugiyama clinic between November 2011 and October 2013. Twenty-five were treated (treatment group) 17 received no (control group). Treatment group 2 days before embryo transfer...
We aimed to assess whether an imbalance of T-helper (Th) 1 and Th2 cells contributes implantation failure pregnancy loss.In this cross-sectional study, 197 consecutive patients with a history repeated (RIF) after three or more embryo transfer (ET) cycles and/or recurrent loss (RPL) two clinical losses underwent Th cell testing. After excluding 42 women aged ≥44 9 vitamin D supplementation, we recruited 146 including 79 RIF 81 RPL. Fourteen had both also 45 fertile 40 general infertile...
Abstract Purpose To clarify the mechanisms of intrauterine platelet‐rich plasma (PRP) infusion that support embryo implantation in vitro fertilization treatment. Methods Blood and endometrial samples were collected from four infertile women. Human stromal cells (HESCs) cultured passaged equally into cell culture dishes each patient. Two treated with PRP twice, other two vehicle. Subsequently, cultures without decidualized 8‐bromoadenosine 3′,5′‐cyclic AMP progesterone for 5 days. Results The...
Abstract Background The aim of this study is to evaluate the relationship between chronic endometritis (CE) and a personalized window implantation (WOI), identified by results endometrial receptivity analysis (ERA), pregnancy outcomes following embryo transfer (ET) based on ERA outcomes. Methods single‐center, cross‐sectional was designed. population consisted 101 infertile women who underwent sampling June 2018 February 2020. We recruited 88 patients testing immunohistochemistry plasma cell...
Problem We aim to investigate whether the peripheral blood T helper (Th) 1 cell level could predict pregnancy outcome in patients who have experienced repeated implantation failure ( RIF , three or more) after ART cycles. Method of study This is a prospective cohort total 124 women with showed elevated Th1/Th2 CD 4 + IFN ‐γ / IL ‐4 ) ratios (≥10.3) and received tacrolimus at Sugiyama Clinic between November 2011 July 2016. Patients were divided into groups as per Th1 levels: <22.8 Low;...
Abstract Problem We aimed to compare the therapeutic effects of hysteroscopic polypectomy with and without doxycycline treatment on chronic endometritis (CE) endometrial polyps. Method study: Design A cross‐sectional study was conducted 267 infertile patients, whom 243 were recruited, who underwent between March 2019 2020. During surgery, specimens for immunohistochemistry analysis plasma cell marker CD138 intrauterine bacterial culture obtained diagnose CE, prevalence CE analyzed. Of 222...
Abstract Aim: Women with unexplained infertility frequently become pregnant after diagnostic laparoscopy. In this study the effect of laparoscopic surgery on such women was evaluated by pregnancy rate surgery. Methods: A total 47 infertile underwent evaluation during period August 2002 to January 2005 in our center. The percentage positive findings and laparoscopy were calculated. patients divided into 5 subgroups according maternal age, rates calculated for each group, compared outcome...
The plasma concentration of 11-deoxycorticosteroids (11-deoxy CS) was measured by competitive protein-binding after extraction with dichloromethane and partitioning the extract between benzene water. When normal subjects were given metyrapone orally, 11-deoxy CS levels rose from 2.0 or less to 12–32 μg/100 ml; ACTH concentrations (radioimmunoassay) concomitantly 0–5 8–11 ng/100 ml. intravenously subjects, than 9–19 Plasma also increased. In patients deficiency 0–7 ml oral metyrapone. method...
Abstract Problem Previously, we reported the clinical efficacy of tacrolimus in women with repeated implantation failures (RIF) immune etiologies. Safety pregnant has been organ transplantations. However, safety for RIF undergoing assisted reproductive technology cycles and their babies not prior. Method study This is a prospective observational 109 or recurrent pregnancy losses (RPL) who showed elevated peripheral blood Th1/Th2 (CD4 + IFN‐γ /CD4 IL‐4 ) cell ratios (≥10.3). All received...
To clarify the efficacy of OPtimization Thyroid function, Thrombophilia, IMmunity and Uterine Milieu (OPTIMUM) treatment strategy on pregnancy outcomes after euploid blastocyst transfer in advanced age women with recurrent implantation failure (RIF) and/or loss (RPL).
Background: Chronic endometritis (CE) significantly contributes to repeated implantation failure (RIF). Although antibiotics are common treatments for CE, some patients do not achieve resolution. Therefore, the use of an alternative method involving administration ImmuBalanceTM (IMB), a combination pre- and probiotics, was explored in current study. Methods: This retrospective study conducted between April 2021 August 2022. A total 819 women with CE were treated antibiotics-1 (doxycycline,...