A5080951673- Mitochondrial Function and Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Formal Methods in Verification
- Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Organ Transplantation Techniques and Outcomes
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Genetic and Kidney Cyst Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- History and Developments in Astronomy
- Surgical Simulation and Training
- Cerebrospinal fluid and hydrocephalus
- Pneumothorax, Barotrauma, Emphysema
- Software Testing and Debugging Techniques
- Liver physiology and pathology
- Acute Ischemic Stroke Management
- Hemoglobin structure and function
Dokkyo Medical University
2009-2024
Akita University Hospital
2021-2024
University of Toyama
2016-2020
Beth Israel Deaconess Medical Center
2014-2019
Harvard University
2014-2019
Akita University
2015
Tokyo University of Pharmacy and Life Sciences
2015
RWTH Aachen University
2011
Chiba University
2011
Universitätsklinikum Aachen
2011
NCoR1 (nuclear receptor corepressor) and SMRT (silencing mediator of retinoid thyroid hormone receptors; NCoR2) are well-recognized coregulators nuclear (NR) action. However, their unique roles in the regulation (TH) signaling specific cell types have not been determined. To accomplish this we generated mice that lacked function either NCoR1, SMRT, or both liver only additionally a global knockout model. Despite corepressors being present liver, deletion euthyroid hypothyroid animals had...
Abstract Background Health information exchange (HIE) may improve diagnostic accuracy, treatment efficacy, and safety by providing treating physicians with expert advice. However, most previous studies on HIE have been observational in nature. Objectives To examine whether collaboration between specialists general practitioners (GPs) rural areas via can outcomes among patients at low-to-moderate risk of cardiovascular disease, kidney stroke. Methods In this randomized controlled trial, the...
StarD7 facilitates phosphatidylcholine (PC) transfer to mitochondria, and is essential for mitochondrial homeostasis. However, the molecular mechanism PC by protein remains poorly understood. Herein, we describe a putative novel transmembrane (TM) domain C-terminal mitochondria-targeting signal (MTS) sequence at N-terminus of StarD7. The mature form integrated and/or associated onto outer leaflet membrane (OMM) in HEPA-1 HepG2 cells. A truncated lacking TM distributed inner space cannot...
Significance Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormones. In absence T3 (3,3′,5-triiodothyronine), TR recruits a multiprotein repressor complex that decreases histone acetylation in vicinity target genes. Nuclear receptor corepressor 1 (NCoR1) is hypothesized to be main interacts with TR. Here we report deletion NCoR1 does not prevent all gene repression and deacetylation across variety mouse models, whereas only lack was able overturn effects...
Perineural cysts, also called Tarlov are dilatations of the nerve root sleeves commonly found in sacrum. The majority cysts asymptomatic and incidentally on routine spine imaging. Symptomatic sacral perineural (SPCs) that induce intractable low-back pain, radicular symptoms, bladder/bowel dysfunction require surgery. However, surgical strategy for symptomatic SPCs remains controversial. authors hypothesized symptoms were caused by an irritation adjacent roots SPCs, developed a wrapping...
StarD7 is a phosphatidylcholine (PC)-specific lipid transfer protein essential for the maintenance of mitochondrial PC composition, morphogenesis, and respiration. Here, we studied role in skeletal myoblast differentiation using mouse C2C12 cells human primary myoblasts. Immunofluorescence immuno-electron microscopy revealed that was distributed cytosol, inner mitochondria space, outer leaflet membrane cells. Unlike kidney embryonic cell line HEK293 cells, proteinase PARL not involved...
Premixed insulin is effective to improve glycemic control; however, clinicians may be less likely know which premixed appropriate for patients. This study aimed evaluate the effects of twice-daily injections lispro on control in type 2 diabetic patients.Forty patients, who had been treated with human protamine mixture 30/70 at least 12 months, were divided into two groups; one group whose blood glucose hours after breakfast was greater than 200 mg/dL, switched mix50, and other <...
Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) the nuclear receptor co-repressor1 (NCoR1) are paralogs regulate (NR) function through recruitment a multiprotein complex that includes histone deacetylase activity. Previous genetic strategies which deleted SMRT in specific tissue or altered interaction between NRs have suggested it may adiposity insulin sensitivity. However, full role adult mice has been difficult to establish because its complete deletion during...
A 62-year-old woman was admitted with dry mouth, general fatigue, and severe back pain. Biochemistry examination showed extreme hypercalcemia (21.2 mg/dL). Bone marrow negative, but needle biopsy of a metastatic lung tumor revealed abnormal plasma cells; thus, multiple myeloma stage III-A finally diagnosed. Serum concentrations both parathyroid hormone-related peptide (PTHrP) macrophage inflammatory protein-1α (MIP-1α) were markedly elevated (PTHrP 7.2 pmol/L, normal <1.1 pmol/L; MIP-1α 84.9...
<i>Objective:</i> Our aim was to investigate the effect of 1-year treatment with raloxifene, a selective estrogen receptor modulator, on plasma lipid profiles in Japanese postmenopausal type 2 diabetic patients. <i>Subjects and Methods:</i> A total 43 women osteoporosis diabetes serum low-density lipoprotein cholesterol (LDL-C) <3.59 mmol/l, triglyceride <1.68 mmol/l high-density (HDL-C) >1.03 who took 60 mg/day raloxifene for 12 months, were enrolled. For...