A5051085519- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Drug-Induced Adverse Reactions
- Hemoglobinopathies and Related Disorders
- Systemic Lupus Erythematosus Research
- Hematological disorders and diagnostics
- SARS-CoV-2 detection and testing
- Cellular Mechanics and Interactions
- Antibiotics Pharmacokinetics and Efficacy
- Metabolism and Genetic Disorders
- HIV/AIDS drug development and treatment
- Renal Diseases and Glomerulopathies
- Intramuscular injections and effects
- Liver Disease Diagnosis and Treatment
- Skin and Cellular Biology Research
- Kawasaki Disease and Coronary Complications
- Vasculitis and related conditions
- Polyomavirus and related diseases
- Diphtheria, Corynebacterium, and Tetanus
- Syphilis Diagnosis and Treatment
Hospital de Dona Estefânia
2016-2025
Universidade Nova de Lisboa
2023
Centro Hospitalar de Lisboa Central
2017-2021
Instituto Politécnico de Lisboa
2021
Rationale In 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB). Objectives This study aimed determine the performance of QFT-Plus, compared with previous generation IGRAs and tuberculin skin test (TST), children TB Europe. Methods Multicentre, ambispective cohort within Paediatric Tuberculosis Network European Trials Group (ptbnet), dedicated paediatric research network...
Patients with nephrotic syndrome are at heightened risk of infections due to the underlying disease pathophysiology and effects immunosuppressive therapies. Varicella-zoster virus (VZV) infection can cause severe complications in immunocompromised individuals. Concerns about safety live attenuated vaccines this population persist. Emerging vaccination strategies incorporate pre-vaccination stratification algorithms based on immunological criteria. We present a case five-year-old male...
Abstract Background In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine clinical characteristics, performance diagnostic tools, outcome IC tuberculosis (TB) in Europe. Methods Multicenter, matched case-control within Pediatric Tuberculosis Network European Trials Group, capturing TB cases <18 years diagnosed 2000–2020. Results A total 417 were included,...
Objective: The aim of this study was to identify the prevalence emergent integrase drug resistance mutations (INSTI-DRMs) in international referrals a perinatal virtual clinic (PVC). Design: A retrospective cohort study. Setting: Monthly multidisciplinary PVC reviewing complex case management for children and adolescents with perinatally acquired HIV (CAWHIV). Participants: One hundred fourteen cases referred virological failure between October 2018 January 2024. Main outcome measures: Data...
Abstract Stevens–Johnson syndrome ( SJS ) and toxic epidermal necrolysis TEN are rare but serious dermatologic diseases with many potential multisystem complications. We describe the case of an 8‐year‐old girl who developed severe / overlap (25% her body surface area was affected) complicated by pancreatitis bronchiolitis obliterans. These complications emphasize need for careful, intensive monitoring possible interdisciplinary team approach to provide optimal treatment follow‐up.
By May 2020, SARS-CoV-2 had caused more than 400 000 deaths worldwide. Initially, hydroxychloroquine was a treatment option for COVID-19. More recent studies have questioned its safety and efficacy and, until stronger evidence is available, it suspended from therapy protocols. We describe our experience treating COVID-19 Portuguese pediatric patients with hydroxychloroquine, having applied protocol monitoring cardiac toxicity.An observational retrospective study of patients, admitted March...
Background Adults are being vaccinated against SARS-CoV-2 worldwide, but the longitudinal protection of these vaccines is uncertain, given ongoing appearance variants. Children remain largely unvaccinated and susceptible to infection, with studies reporting that they actively transmit virus even when asymptomatic, thus affecting community. Methods We investigated if saliva an effective sample for detecting RNA antibodies in children, associated viral levels infectivity. For that, we used a...
A previously healthy 11-year-old girl presented on May 2020, during the first pandemic wave, with a month-long history of bilateral wrist and fingers arthralgia, dry cough, chest pain orthopnea. After treatment azithromycin non-steroidal anti-inflammatory drugs, due to persistent non-quantified low-grade fever for 2 days, she was admitted. She denied rash, diarrhoea taking other medication besides ones prescribed. Her physical examination revealed symmetric second third metacarpophalangeal...
Aplasia cutis congenita is an uncommon condition (estimated global incidence 0.5–1 in 10 000 neonates)1 characterised by a localised defect of all skin layers and subcutaneous tissue, sometimes extending to the underlying bone meningeal layers.2 Some possible complications include haemorrhage, trauma, venous sinus thrombosis infection (including meningitis).3 The management …
Coronavirus disease 2019, or COVID-19, in children is usually a mild disease, but severe illness has been reported. Currently, the therapy benefits of antiviral experimental drugs are still uncertain. The main aim this study to describe experience level III hospital regarding therapeutic management hospitalized with COVID-19 and characterize clinical features evolution.
To the Editors: Gonococcal conjunctivitis (GC) is rare in nonneonatal populations and incubation period between exposure ocular manifestations 3–19 days.1 In children, after neonatal period, most likely cause of transmission due to sexual abuse, although other routes (fomites or manual transmission) may exist.2 confirm suspicion it extreme importance look for oral, genital anal infection, which by routes, than assault, not possible.3 Typically, GC presents with a hyperacute onset very rapid...
O défice de zinco no lactente pode ocorrer por aumento das necessidades ou diminuição do aporte. A deficiência sintomática transitória resulta uma alteração transportador a nível da glândula mamária, conduzindo níveis reduzidos leite materno. Lactentes sob aleitamento materno exclusivo apresentam, nestes casos, um As manifestações clínicas clássicas traduzem-se lesões cutâneas acrais e periorificiais, alopecia diarreia, sendo indistinguíveis outras causas zinco. Verifica-se, contudo,...
When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played role injury due antituberculosis drugs. Ketogenic has been linked injury, and while its pathophysiology remains obscure, carnitine depletion could play role, as it mechanism common KD drug regimens.
Objective To describe the demographic, clinical, laboratory and imaging features of first 300 SARS-CoV-2-infected children presenting to a tertiary paediatric centre in Portugal. Design Single-centre, retrospective, descriptive study patients who had confirmed SARS-CoV-2 infection from 7 March 20 September 2020. Setting Tertiary referral (Hospital Dona Estefânia, Lisbon, Portugal). Patients 18 years or younger. Main outcome measures Incidence, mortality, age infection, clinical...
Introduction. Bone and joint tuberculosis (BJTB) is rare in developed countries, particularly the paediatric population. Hypothesis/Gap Statement. The clinical features sequelae of BJTB Europe are not well characterized should be assessed to achieve a better approach. Aim. To assess management outcomes BJTB. Methodology. Longitudinal observational study all patients (0–17 years old) diagnosed with between 2008 2020 tertiary-care hospital. Results. We identified 18 BJTB, median age 10 (IQR...
Structured abstract IMPORTANCE Adults are being vaccinated against SARS-CoV-2 worldwide, but the longitudinal protection of these vaccines is uncertain, given ongoing appearance variants. Children susceptible to infection, and some studies reported that they actively transmit virus even when asymptomatic, thus affecting community. Methods easily test infected children track carry in demand. OBJECTIVE To determine if saliva an effective sample for detecting RNA antibodies aged 10 years under,...
A 4-year-old boy with a history of autism spectrum disorder presented at the emergency department (ED) after presentation fever, productive cough and oral lesions for week, that became progressively worse. On previous day, swelling lips conjunctival hyperaemia occurred.