Medication non-adherence is one of the major problems in treating patients with depression.Non-adherence results an increased risk relapse and reduced quality life.The objective this review was to summarize studies that focused on factors associated antidepressant medication depression.Literature searches were performed using PubMed/Medline Google Scholar.The search limited articles published English language peer-reviewed journals between January 2000 December 2019.Studies analyzed...

Background Poor sleep quality and internet addiction are significant issues affecting adolescents globally, Nepal is no exception. Several studies have independently assessed the prevalence associated factors of poor among Nepali youth, but relationship between sleep-related attributes remains unexplored. This study aimed to explore contributing along with quality-related addiction. Material methods A cross-sectional was conducted 243 Dakshinkali Municipality, Nepal. Pittsburgh Sleep Quality...

Background: Antimicrobial resistance (AMR) is a global health problem contributing to increasing rates of morbidity and mortality throughout the world. Inadequate knowledge misconceptions surrounding antibiotics their overuse can significantly contribute growth spread AMR. This study aimed assess knowledge, attitudes, practices (KAP) regarding antibiotic use among undergraduates in Pokhara, Nepal, examine associations attitudes with demographic factors specific practices. Methods: A...

Background: The COVID-19 among humans is spreading heavily and largely impacting the mental health of general population, students, care workers worldwide. Hence, this review aims to summarize literatures addressing impact pandemic on workers.
 Methods: Published articles concerning related outbreak have been considered reviewed.
 Results discussion: Mental symptoms stress, anxiety, depression are common psychological reactions in workers. This collectively influences daily...

Objective. The present study is aimed at evaluating the side effects of antidepressant drugs, medication adherence (MA), and associated factors among patients diagnosed with depression a psychiatric hospital in western Nepal. Methods. A prospective cross-sectional was conducted 174 visiting outpatient clinic hospital. effect checklist (ASEC) used to classify reported drug into mild, moderate, severe types. Naranjo adverse reaction (ADR) probability scale employed assess ADRs, Morisky Green...

Hypertension a "silent killer" is serious global health problem, whose prevalence increasing in Nepal.This study aimed to determine the attitude and practice of hypertension among anti-hypertensive medication users tertiary care teaching hospital western Nepal.A hospital-based cross-sectional design was used 136 hypertensive patients under medication, aged ⩾ 30 years, visiting medical outpatient department, ward, geriatric using non-probability convenience sampling technique. Semi-structured...

Background. Adverse drug reactions (ADRs) are the known cause of morbidity and mortality, resulting in increased hospitalization, healthcare costs, complications, decreased adherence patients with depression. This study is aimed at evaluating adverse due to antidepressants among depression psychiatric hospital Nepal. Methods. A hospital-based prospective observational was conducted 47 using purposive sampling techniques visiting a private hospital. The causality, severity, preventability...

High utilization and irrational use of antibiotics in an intensive care unit increases microbial resistance, morbidity, mortality, costs.This study aimed to evaluate the utilization, sensitivity cost analysis used medical a tertiary teaching hospital Nepal.A prospective cohort was conducted on patients admitted at central Nepal from July September 2016. Antibiotic defined daily dose per 100 bed-days patient were calculated. Descriptive statistics performed using IBM-SPSS 20.0.A total 365...

Aim: We aimed to evaluate the impact of pharmaceutical service intervention on medication adherence and patient-reported outcomes among patients diagnosed with depression in a private psychiatric hospital Nepal. Methods: A single-center, open trial parallel design was conducted 18 65 years aged patients, under antidepressant medication(s) for ≥2 months. Patients were randomised into either or control group. The group (n = 98) received usual care, while intervention. two groups compared using...

This study aimed to assess the relationship between menstruation-related attributes and mental distress in adolescent girls. A cross-sectional was conducted Rangeli Municipality, Nepal, among 270 Data were collected using a self-administered questionnaire. Unadjusted adjusted odds ratios (aOR) calculated at 5% level of significance identify factors associated with depression, anxiety stress. Of girls, 28.9% (95% CI: 23.5%-35.2%) experienced anxiety, 14.4% 10.0%-18.5%) stress 32.2%...

Alcohol consumption is a significant public health concern among young people worldwide. While alcohol use culturally embedded in many Nepalese communities, evidence regarding the prevalence of problematic drinking and its associated factors remains scarce youths. This study aims to assess their management undergraduate students Bhaktapur, Nepal. A cross-sectional was conducted 304 The Use Disorders Identification Test (AUDIT) used drinking. Pearson's chi-square test multivariable logistic...

The global aging population is growing rapidly, and Nepal no exception. This increase driven by changes in socioeconomic conditions, health behaviours, advancements the system. In Nepal, almost a quarter of national are older adults (≥45 years), whose status rarely elaborated. study was carried out to assess socioeconomic, behavioural, health-related characteristics Nepal.

Background: Overweight and obesity is the underlying cause of death for about 3 million people each year. More than 100 individuals are obese in India. Few studies have been carried out among Indian undergraduate students where irregular dietary pattern, stress anxiety more prevalent due to academic pressure. The objective this study was estimate prevalence over-weight Medical Allied Science students.Methods: cross-sectional conducted 2017 922 medical allied science Jawaharlal Nehru College,...

Background: Drug dosage adjustment is essential for chronic kidney disease patients (CKD) patients. If it not done properly, this will lead to an increase in toxicity and a decrease the effectiveness of therapy. The objective present study was assess whether appropriate adjustments were made hospitalized CKD Methods: A descriptive cross-sectional carried out among 80 with stage II V admitted nephrology ward Chitwan Medical College Teaching Hospital, Nepal between 1st August 30th November...

This study aimed to identify, evaluate the antibiotic resistance pattern and detect virulence genes iss, ompT in avian pathogenic Escherichia coli (APEC) from broiler chickens central Nepal. To determine of obtained isolates, Kirby-Bauer disc diffusion method was used with six different commercial discs: Amikacin, Gentamycin, Ciprofloxacin, Doxycycline, Chloramphenicol Levofloxacin. A polymerase chain reaction (PCR) assay for selected isolates (n=40) screen presence iss after extraction DNA...

Introduction: Mucoadhesive buccal films are most recently developed and preferred over tablet because of the flexibility, better bioavailability, cost effectiveness, good patient compliance it offers
 Objective: The study aimed to formulate mucoadhesive Clobetasol Propionate with reduced side effects, controlled release compliance, suitable for management oral lichen planus.
 Methods: Buccal Films were prepared by incorporation along polymers like Hydroxy Propyl Methyl Cellulose...

Anticoagulants have a wide spectrum of use and risks associated with their therapy due to narrow therapeutic range. This study aimed evaluate the anticoagulant utilization cost analysis in patients admitted cardiology ward tertiary care hospital western Nepal.A prospective cohort was conducted Manipal Teaching Hospital (MTH), Pokhara, Kaski, Nepal, from August November 2019. All (n = 132) aged ≥18 years either gender receiving anticoagulants for any indication were included study....

Patients with hypertension in Nepal are often known to have poor medication adherence and quality of life. This randomised controlled trial aimed evaluate the impact a hospital pharmacist-delivered individualised pharmaceutical service (P-DIPS) intervention on blood pressure, health-related life (HRQoL) among patients setting Nepal.

Purpose The purpose of this study is to evaluate the prescribing pattern proton pump inhibitors (PPIs) in patients visiting outpatient general medical clinic a Tertiary Care Teaching Hospital. Design/methodology/approach A hospital-based cross-sectional was conducted 419 aged ≥18 years, medicine tertiary hospital and prescribed with at least one PPI, from July September 2016 using purposive sampling technique. Descriptive statistics were performed IBM-SPSS 20.0 (IBM Corporation, Armonk, NY,...

Abstract Background: Hypertension a “silent killer” is serious global health problem, whose prevalence increasing in Nepal. This study aimed to determine the attitude and practice of hypertension among antihypertensive medication users tertiary care teaching hospital western Methodology: A hospital-based cross-sectional was conducted 136 hypertensive patients under medication, aged ≥30 years, visiting medical outpatient department, ward, geriatric using non-probability convenience sampling...

Background: The present study determined the prescription pattern of antidepressants, adverse drug reactions (ADRs), level adherence, and factors affecting it.
 Methods: This prospective cross-sectional was conducted with depression patients (n=174; 55.74% female) from August 2019 to November at a psychiatric hospital Pokhara, Kaski, Nepal. Naranjo ADR Probability Scale employed assess ADRs. rate medication adherence (MA) using Morisky MA Measurement Scale-Eight. Descriptive statistics...

Objective: Patients with chronic obstructive pulmonary disease (COPD) are known to have poor medication adherence in Nepal. Various factors affect the of COPD patients. Therefore, we aimed evaluate and its associated among patients tertiary care hospitals central Nepal.
 Methods: A hospital-based cross-sectional study was carried out 164 aged ≥18 years, diagnosed under medication(s) for at least 6 months from September 2017 March 2018, a hospital Nepal, using purposive sampling...