A5081587226- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Extracellular vesicles in disease
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Gut microbiota and health
- Bacterial Infections and Vaccines
- Phagocytosis and Immune Regulation
- Advanced Biosensing Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Listeria monocytogenes in Food Safety
- Barrier Structure and Function Studies
- Viral Infections and Immunology Research
- Neurogenesis and neuroplasticity mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Acute Myeloid Leukemia Research
University of Florence
2018-2025
Azienda Ospedaliero-Universitaria Careggi
2025
Scuola Internazionale Superiore di Studi Avanzati
2021-2024
Abstract Extracellular vesicles (EVs) are lipid-bilayered particles, containing various biomolecules, including nucleic acids, lipids, and proteins, released by cells from all the domains of life performing multiple communication functions. Evidence suggests that interaction between host immune fungal EVs induces modulation system. Most studies on have been conducted in context infections; therefore, there is a knowledge gap what concerns production yeasts other contexts rather than...
Fatty acid ethanolamides acting on proliferator-activated receptor (PPAR)-α are among the endogenous lipid molecules that attenuate inflammatory processes and pain sensitivity. Whereas these properties well-known for palmitoylethanolamide (PEA), efficacy of oleoylethanolamide (OEA, first described as a satiety hormone synthesized in jejunum) has been overlooked. In this study, we aimed to evaluate effect OEA administration mouse model colitis. C57BL/6J mice were exposed 2.5% dextran sodium...
Natalizumab (NTZ) and autologous hematopoietic stem cell transplantation (AHSCT) are two successful treatments for relapsing-remitting multiple sclerosis (RRMS), an autoimmune T-cell-driven disorder affecting the central nervous system that is characterized by relapses interspersed with periods of complete or partial recovery. Both RRMS have been documented to impact T-cell subpopulations receptor (TCR) repertoire in terms clone frequency, but, so far, link between naive memory populations,...
In neuroinflammation, astrocytes play multifaceted roles that regulate the neuronal environment. Astrocytes sense and respond to pro-inflammatory cytokines (CKs) and, by a repertoire of intracellular Ca
Chronic inflammation is involved in the genitourinary syndrome of menopause (GSM) and beneficial effects androgens vagina have been described. We investigated potential involvement human smooth muscle cells (hvSMCs) inflammatory response immunomodulatory effect androgen receptor (AR) agonist dihydrotestosterone (DHT). HvSMCs isolated from menopausal women were evaluated for sex steroids receptors toll-like mRNA expression, left untreated or treated vitro with lipopolysaccharide (LPS) IFNγ,...
T cells play a key role in the pathogenesis of multiple sclerosis (MS), chronic, inflammatory, demyelinating disease central nervous system (CNS). Although several studies recently investigated T-cell receptor (TCR) repertoire cerebrospinal fluid (CSF) MS patients by high-throughput sequencing (HTS), deep analysis on similarities and differences among compartments is still missing.
ABSTRACT The exposure of cancer neoantigens to the patient's immune system by HLA sustains surveillance and shapes tumour clonal evolution. In acute myeloid leukaemia (AML), mutation Nucleophosmin 1 (NPM1) at exon 12 represents a driver mutation, raising set highly immunogenic peptides. Whereas phenomenon loss is mechanism escape broadly described in allogeneic haematopoietic stem cell transplantation, less known about this diagnosis. study, we present case 47‐year‐old patient with de novo...
Epstein-Barr virus (EBV) is a known risk factor for multiple sclerosis (MS), even though the underlying molecular mechanisms are unclear and engage immune pathways. Furthermore, ultimate role of EBV in MS pathogenesis still elusive. In contrast, Cytomegalovirus (CMV) has been identified as protective MS. This study aims to identify MS-associated genes that overlap with interactome examine their expression glial cell subtypes. We used P-HIPSTer, GWAS, Human Protein Atlas (HPA) derive data on...
Neuroinflammation is an escalation factor shared by a vast range of central nervous system (CNS) pathologies, from neurodegenerative diseases to neuropsychiatric disorders. CNS immune status emerges the integration responses resident and not cells, leading alterations in neural circuits functions. To explore spinal cord astrocyte reactivity inflammatory threats we focused our study on effects local inflammation controlled micro-environment, organotypic slices, developed mouse embryos. These...
Magnetite nanoparticles enter non-phagocytic myelin-specific T cells and reach the central nervous system after <italic>in vivo</italic> transfer.
Food contamination can be a serious concern for public health because it related to the severe spreading of pathogens. This is main issue, especially in case fresh fruits and vegetables; indeed, they have often been associated with gastrointestinal outbreak events, due pathogenic bacteria. However, little known about physiological adaptation bacterial response stresses encountered host plant. Thus, this work aimed investigate commensal E. coli strain while growing tomato pericarp....
Abstract Background Melanoma progression is based on a close interaction between cancer cells and immune in the tumor microenvironment (TME). Thus, better understanding of mechanisms controlling TME dynamics composition will help improve management this dismal disease. Work from our other groups has reported requirement an active Hedgehog-GLI (HH-GLI) signaling for melanoma growth stemness. However, role downstream GLI1 transcription factor remains largely unexplored. Methods The...
Introduction Neuroinflammation is a hallmark of multiple neurodegenerative diseases, shared by all pathological processes which primarily impact on neurons, including Central Nervous System (CNS) injuries. In reactive CNS, activated glia releases extracellular vesicles (EVs), nanosized membranous particles known to play key role in intercellular communication. EVs mediate neuroinflammatory responses and might exacerbate tissue deterioration, ultimately influencing disease progression....
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Relapsing-remitting multiple sclerosis (RRMS) is a demyelinating disease in which pathogenesis T cells have major role. Despite the unknown etiology, several risk factors been described, including strong association with human leukocyte antigen (HLA) genes. Recent findings showed that HLA class I-G (HLA-G) may be tolerogenic MS, but further insights are required. To deepen HLA-G role MS inflammation, we measured soluble (sHLA-G) and cytokines serum level 27 patients RRMS at baseline after 12...