A5064150908- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Microbial Community Ecology and Physiology
- Bacterial Genetics and Biotechnology
- Plant-Microbe Interactions and Immunity
- Pharmaceutical and Antibiotic Environmental Impacts
- Essential Oils and Antimicrobial Activity
- Alkaloids: synthesis and pharmacology
- Gut microbiota and health
- Biochemical and Molecular Research
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Plant Pathogenic Bacteria Studies
- Algal biology and biofuel production
- Coastal wetland ecosystem dynamics
- Phytochemistry and Biological Activities
- Microbial bioremediation and biosurfactants
- Evolution and Genetic Dynamics
- Bacterial Infections and Vaccines
- Constructed Wetlands for Wastewater Treatment
- Legionella and Acanthamoeba research
- Plant tissue culture and regeneration
- Global Health Care Issues
Università di Camerino
2022-2024
University of Florence
2019-2023
University of Palermo
2020-2021
Comisión Honoraria de Lucha contra el cáncer
1994
Esophageal cancer has constituted a major public health problem in Uruguay, with age-adjusted death rates of 14.5×105 for males and 3.8×105 females. A case-control study was undertaken to ascertain the possible association local custom drinking infusions llex paraguariensis (“maté”) esophagus, after controlling well-known risk factors, such as alcohol tobacco consumption. Two hundred twenty-six patients esophageal 469 controls (control:case = 2.1) were interviewed at time admission or...
Streptomycetes are widely distributed in nature and characterized by a complex life cycle that involves morphological differentiation. They very relevant industry because they produce about half of all clinically used antibiotics, as well other important pharmaceutical products natural origin. Streptomyces coelicolor is model organism for the study bacterial differentiation bioactive molecule production. S. produces extracellular vesicles which carry many molecules, such proteins...
The insurgence of antibiotic resistance and emergence multidrug-resistant (MDR) pathogens prioritize research to discover new antimicrobials. In this context, medicinal plants produce bioactive compounds pharmacological interest: some extracts have antimicrobial properties that can contrast different pathogens. For such a purpose, Origanum vulgare L. (Lamiaceae family) is aromatic plant, whose essential oil (EO) recognized for its antiseptic, antiviral activities. cultivable bacteria from...
Multidrug-resistant pathogens represent a serious threat to human health. The inefficacy of traditional antibiotic drugs could be surmounted through the exploitation natural bioactive compounds which medicinal plants are great reservoir. finding that bacteria living inside plant tissues, (i.e., endophytic bacterial microbiome) can influence synthesis aforementioned leads necessity unraveling mechanisms involved in determination this symbiotic relationship. Here, we report genome sequence...
Medicinal aromatic plants' essential oils (EOs) are mixtures of volatile compounds showing antimicrobial activity, which could be exploited to face the emerging problem multi-drug resistance. Their chemical composition can depend on interactions between plant and its endophytic microbiota, is known synthesize organic (VOCs). However, it still not clear whether those metabolites contribute aroma profile EOs. The aims this study were characterize medicinal O. vulgare ssp. bacterial endophyte...
The pressing issue of the abundance antibiotic resistance genes and resistant bacteria in environment (ARGs ARB, respectively) requires procedures for assessing risk to health. chemo-centric environmental assessment models identify hazard(s) a dose–response manner, obtaining exposure, toxicity, risk, impact policy. However, this approach based on ARGs/ARB evaluation from quantitative viewpoint shows high unpredictability because cannot be considered as standard hazardous molecules: ARB...
Marinomonas sp. ef1, in 1% (v/v) of diesel and biodiesel was able to reproduce itself, confirmed by the OD 600 curve; decrease COD parameter degradation diesel; case bacteria synthesized a secondary fluorescent compound.
Medicinal plants play an important role in the discovery of new bioactive compounds with antimicrobial activity, thanks to their pharmacological properties. However, members microbiota can also synthesize molecules. Among these, strains belonging genera Arthrobacter are commonly found associated plant’s microenvironments, showing plant growth-promoting (PGP) activity and bioremediation as secondary metabolite producers has not been fully explored. The aim this work was characterize sp. OVS8...
In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated many others still deserve further investigations. this regard, the possible role small open reading frames (smORFs) in actinomycete elusive. Streptomyces coelicolor, inactivation smORF trpM (SCO2038) - whose product modulates L-tryptophan biosynthesis...
Improvement of industrial productions through more environment-friendly processes is a hot topic. In particular, land and marine environment pollution main concern, considering that recalcitrant compounds can be spread persist for long time. this context, an efficient cost-effective treatment wastewater derived from applications crucial. Phytodepuration has been considered as possible solution it based on the use plants their associated microorganisms to remove and/or transform pollutants....
Gene elongation is a molecular mechanism consisting of an in-tandem duplication gene and divergence fusion the two copies, resulting in constituted by divergent paralogous modules. The aim this work was to evaluate importance evolution histidine biosynthetic genes propose possible evolutionary model for some them. Concerning hisA hisF, which code homologous (β/α)8-barrels, it has been proposed that extant could be result cascade elongation/domain shuffling events starting from ancestor...
Abstract Membrane vesicles (MVs) are spherical particles with nanoscale dimensions and characterized by the presence of diverse cargos, such as nucleic acids, proteins, lipids, cellular metabolites. Many examples (micro)organisms producing MVs reported in literature. Among them, bacterial particular interest because they now considered fourth mechanism horizontal gene transfer. Streptomyces bacteria well-known for their ecological roles ability to synthesize bioactive compounds, coelicolor...
Food contamination can be a serious concern for public health because it related to the severe spreading of pathogens. This is main issue, especially in case fresh fruits and vegetables; indeed, they have often been associated with gastrointestinal outbreak events, due pathogenic bacteria. However, little known about physiological adaptation bacterial response stresses encountered host plant. Thus, this work aimed investigate commensal E. coli strain while growing tomato pericarp....
ABSTRACT Histidine biosynthesis is one of the most characterized metabolic routes for its antiquity and central role in cellular metabolism; indeed, it represents a cross-road between nitrogen metabolism de novo synthesis purines. This interconnection due to activity imidazole glycerol phosphate synthase, heterodimeric enzyme constituted by products two his genes, hisH hisF, encoding glutamine amidotransferase cyclase, respectively. Despite their interaction was suggested several vitro...
Background: Rising number of multidrug-resistant human pathogens demands novel antibiotics: to this aim, unexplored natural sources are investigated find new compounds. In context, bacteria associated medicinal plants, including Phragmites australis, might represent an important source antimicrobial Materials & methods: the present work, 21 bacterial endophytes isolated from P. australis roots were tested, by cross-streaking, for their inhibitory activity against 36 food, clinical patients...
The urban plan of Palermo (Sicily, Italy) has evolved throughout Punic, Roman, Byzantine, Arab, and Norman ages until it stabilized within the borders that correspond to current historic center. During 2012 2013 excavation campaign, new remains Arab settlement, directly implanted above structures Roman age, were found. materials investigated in this study derived from so-called Survey No 3, which consists a rock cavity subcylindrical shape covered with calcarenite blocks: was probably used...
Acquarossa river (Viterbo, Italy) was the site of a prospering Etruscan civilization thanks to metallurgical activity around 625–550 B.C. This caused spread heavy metals throughout area. Rocks along probably act as filter for these elements and they are covered by two different biofilms (epilithons). They differ both color bacterial composition. One is red enriched with Pseudomonas strains, while other one black Acinetobacter most represented genus. Along lay Infernaccio waterfalls, whose...
The Sasso Fratino Integral Nature Reserve (Italy) aims to protect nature and territory. Since no anthropic activities are allowed, it represents a good model study the bacterial community of wild environment. aim this work was characterise cultivable total soil samples from reserve in terms taxonomy, composition, structure. Seven were collected at different altitudes, chemical microbiota, antibiotic resistance profiles isolates investigated. Total communities, studied through Next Generation...