A5010077848- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Escherichia coli research studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Enzyme Structure and Function
- Antibiotics Pharmacokinetics and Efficacy
- Blood disorders and treatments
- Cellular transport and secretion
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Renal and related cancers
- Drug-Induced Adverse Reactions
- Bacterial Infections and Vaccines
- Cytomegalovirus and herpesvirus research
- Cancer Research and Treatments
- Toxin Mechanisms and Immunotoxins
- CAR-T cell therapy research
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Herpesvirus Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Monoclonal and Polyclonal Antibodies Research
- Poxvirus research and outbreaks
University of Cambridge
2013-2021
National Institute for Health Research
2016
University of Bristol
2014
Immune landscape of the human kidney Single-cell RNA sequencing has begun to shed light on full cellular diversity specific organs. However, these studies rarely examine organ-specific immune cells. Stewart et al. sequenced healthy adult and fetal samples at a single-cell level define heterogeneity in epithelial, myeloid, lymphoid From this dataset, they identified zonation cells, with relevance disease varied perturbations that occur different tumor settings. This profiling generates...
Vaccinia virus (VACV) expresses many proteins that are non-essential for replication but promote virulence by inhibiting components of the host immune response to infection. These immunomodulators include a family have, or predicted structure related B-cell lymphoma (Bcl)-2 protein. Five members VACV Bcl-2 (N1, B14, A52, F1 and K7) have had their crystal solved, others been characterized function assigned (C6, A46), be uncharacterized hitherto (N2, B22, C1). Data presented here show N2 is...
How cytotoxic T lymphocytes (CTLs) sense cell receptor (TCR) signaling in order to specialize an area of plasma membrane for granule secretion is not understood. Here, we demonstrate that immune synapse formation led rapid localized changes the phosphoinositide composition membrane, both reducing phosphoinositide-4-phosphate (PI(4)P), PI(4,5)P2, and PI(3,4,5)P3 increasing diacylglycerol (DAG) PI(3,4)P2 within first 2 min formation. These reduced negative charge across synapse, triggering...
Type III secretion systems are found in many Gram-negative bacteria. They activated by contact with eukaryotic cells and inject virulence proteins inside them. Host cell detection requires a protein complex located at the tip of device's external injection needle. The Shigella (TC) is composed IpaD, hydrophilic protein, IpaB, hydrophobic which later forms part pore host membrane. Here we used labelling crosslinking methods to show that TCs from ΔipaB strain contain five IpaD subunits while...
Cytotoxic T lymphocytes (CTLs) are key effector cells in the immune response against viruses and cancers, killing targets with high precision. Target cell recognition by CTL triggers rapid polarization of intracellular organelles toward synapse formed target cell, delivering cytolytic granules to synapse. Single amino acid changes within peptides binding MHC class I (pMHCs) sufficient modulate degree killing, but exactly how this impacts choreography centrosome granule delivery remains...