A5031100261- Diabetes Management and Research
- Diabetes Treatment and Management
- Cancer Treatment and Pharmacology
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Colorectal Cancer Treatments and Studies
- Pancreatic function and diabetes
- Mycobacterium research and diagnosis
- Biomedical and Engineering Education
- Pharmaceutical Economics and Policy
- Hernia repair and management
- Economic and Financial Impacts of Cancer
- Neutropenia and Cancer Infections
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Breast Lesions and Carcinomas
- Blood groups and transfusion
- Blood disorders and treatments
- Surgical Sutures and Adhesives
- Gestational Trophoblastic Disease Studies
- Reconstructive Surgery and Microvascular Techniques
- Parvovirus B19 Infection Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biotechnology and Related Fields
- Cardiac and Coronary Surgery Techniques
Sanofi (France)
2020
Cairns Hospital
2020
Freeman Hospital
1990-1991
In a series of 61 consecutive patients undergoing heart, heart and lung, lung transplantation, 24 were known to be cytomegalovirus (CMV) antibody negative on the day transplantation. Enzyme linked immunosorbent assays (ELISA) for CMV IgG performed donor samples operation. 16 susceptible test was only preventive measure taken use blood products from CMV-antibody donors. None these acquired primary infection with CMV. another six serum found contain specific IgG, in patients, including one...
Abstract: Epstein‐Barr virus (EBV)‐associated post‐transplant lymphoproliferative disease (PTLD) is a serious complication of organ and bone marrow transplantation. The importance EBV matching between recipient donor remains unclear. Between October 1987 December 1997, 64 pediatric cardio‐pulmonary transplants were performed at this center (58 hearts, two heart/lungs, four sequential single lungs). viral capsid antigen (VCA) immunoglobulin G (IgG) status both was determined the time...
There is a paucity of information on real world management African adult patients with type 1 diabetes mellitus (T1DM). We aimed to describe cohort adults T1DM. The International Diabetes Management Practices Study an observational survey conducted from 2005 2017. Data were collected in seven individual waves countries Asia, Africa, East Europe, and Latin America. Wave 7 was 2016 2017 the included 12 countries. Questionnaires administered clinicians patients. Analyses mainly descriptive....
Objectives: Management of diabetes is a balancing act preventing state hyperglycaemia while avoiding episodes hypoglycaemia. Limited information currently available on the incidence hypoglycaemia in South African people diagnosed with diabetes. Data regarding management and population was collected as part Wave 7 International Diabetes Practices Study (IDMPS).Design methods: During this observational study first 10 adult individuals type 2 five 1 presenting to site during two-week period...
The role of a Medical Science Liaison (MSL) is growing importance to pharmaceutical, biotechnology, diagnostic and medical device companies. Through scientific engagement MSLs add value clinical practice, ultimately benefiting patients. MSL dynamic encompasses in-depth product disease knowledge together with the ability communicate relevant, unbiased information concisely timely. Tasks are focused on contributing towards advancement knowledge, data generation dissemination. Professional...
Oxaliplatin is a standard first-line treatment for metastatic colorectal cancer. The objectives were to document the therapeutic management of oxaliplatin in South Africa, determine incidence and severity sensory neuropathy, record 2-year survival rate. Meccelox was prospective, noncontrolled, open label, multicentre, observational survey adult patients with stage IV cancer treated oxaliplatin-based chemotherapeutic regimens. study conducted from August 2007 November 2011 29 sites Africa by...
Docetaxel-based chemotherapy regimens have substantially improved survival and recurrence rates for cancer patients. Safety profile of docetaxel includes toxicities, particularly a high risk neutropenia febrile neutropenia. Granotax was prospective, open label, multicentre, national phase IV study that evaluated the incidence severity in adult patients with solid tumors being treated docetaxel-based regimen while receiving GCSF lenograstim. Among 394 enrolled grade 3-4 16.2% 1.5%, far lower...
Breast cancer is the leading among South African women. There limited epidemiological data on triple-negative breast (TNBC). Taxpas was a nonrandomized observational survey conducted in multiple centres Africa from April 2004 to December 2010. 1632 female patients diagnosed with cancer, median age of 51 years, were enrolled survey. Patients treated docetaxel-based chemotherapy regimen. The objective study assess and survival data. incidence TNBC 14%. one-year rate for total cohort 84%. early...
Glucose clamp studies are used to determine pharmacokinetics (PK) and pharmacodynamics (PD) of analogue insulins. With the development longer-acting basal insulins, including glargine 300 (Gla-300) insulin degludec (IDeg), results from numerous glucose readily available. However, interpreting PK/PD profiles in a scientifically sound manner can be challenging feat. This is first series publications that will suggest practical tips for comparing studies. Variations methodology, duration...
Diabetes is a major economic burden and has rapidly increased worldwide. Type 2 diabetes, which accounts for 90–95% of cases, particularly in the developing world. Early treatment intensification may decrease morbidity mortality diabetes by lowering risk related chronic complications. The majority patients, however, do not achieve glycaemic targets, consequently suffer from complications secondary to suboptimal control. A large number epidemiological studies or national registers have been...
Glucose clamp studies form an integral part of the early development insulin therapies. Data generated in these are used to establish pharmacokinetic (PK) and pharmacodynamic (PD) profiles agents, but methodological differences confound comparison results from different glucose studies. The first this series on discussed practical tips for interpretation second compares PK/PD longer-acting basal analogue insulins, degludec (IDeg) glargine U300 (Gla-300). patient populations with insulins...
Glucose clamp studies form an integral part of the early development insulin therapies. Data generated in these are used to establish pharmacokinetic (PK) and pharmacodynamic (PD) profiles agents, but methodological differences confound comparison results from different glucose studies. The first this series on discussed practical tips for interpretation second compares PK/PD longer-acting basal analogue insulins, degludec (IDeg) glargine U300 (Gla-300). patient populations with insulins...
Glucose clamp studies are used to determine pharmacokinetics (PK) and pharmacodynamics (PD) of analogue insulins. With the development longer-acting basal insulins, including glargine 300 (Gla-300) insulin degludec (IDeg), results from numerous glucose readily available. However, interpreting PK/PD profiles in a scientifically sound manner can be challenging feat. This is first series publications that will suggest practical tips for comparing studies. Variations methodology, duration...
Background: Neuroendocrine tumours are known to impact patients’ quality of life because the symptoms caused by hypersecretion serotonin and other peptides, in particular diarrhoea flushing.Aim: The Q-SYMTU study was a prospective, observational registry that included 24 symptomatic patients with gastroenteropancreatic neuroendocrine tumours.Setting: Multiple oncology practices South Africa.Method: Patients’ level satisfaction evaluated for 6-month period from initiation treatment lanreotide...