A5010568353- Cutaneous lymphoproliferative disorders research
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Plant and Fungal Interactions Research
- Protein Degradation and Inhibitors
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Mast cells and histamine
- Systemic Sclerosis and Related Diseases
- Phytochemical compounds biological activities
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
Institute of Human Genetics
2022-2025
Polish Academy of Sciences
2022-2025
Cutaneous T-cell lymphomas (CTCL) are a group of rare hematological malignancies characterized by infiltration malignant T-cells into the skin. Two main types CTCL constitute Mycosis Fungoides (MF), more indolent form disease, and Sézary syndrome (SS), aggressive leukemic variant with blood involvement. presents significant clinical challenge due to its very nature, poor prognosis, treatment resistance, date, disease remains incurable. Histone deacetylase inhibitors have gained attention in...
Transmembrane protein 244 (TMEM244) was annotated to be a member of the TMEM family, which are is component cell membranes and involved in many cellular processes. To date, expression TMEM244 has not been experimentally confirmed, its function clarified. Recently, gene acknowledged diagnostic marker for Sézary syndrome, rare cutaneous T-cell lymphoma (CTCL). In this study, we aimed determine role CTCL cells. Two lines were transfected with shRNAs targeting transcript. The phenotypic effect...