A5052644643- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Protein Tyrosine Phosphatases
- Bone Metabolism and Diseases
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Bone health and treatments
- Neurobiology and Insect Physiology Research
- Hypothalamic control of reproductive hormones
- Cytokine Signaling Pathways and Interactions
- Neuropeptides and Animal Physiology
- Animal Nutrition and Physiology
- Reproductive Biology and Fertility
- Childhood Cancer Survivors' Quality of Life
- Bone and Dental Protein Studies
- Regulation of Appetite and Obesity
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Biochemical Analysis and Sensing Techniques
- Alkaline Phosphatase Research Studies
- Cancer Research and Treatments
- Genetic Syndromes and Imprinting
- Cancer Risks and Factors
- Biochemical effects in animals
- Congenital heart defects research
University of Minnesota
2010-2023
University of Minnesota Medical Center
1989-2023
Twin Cities Orthopedics
2013-2016
Animal Science Research Institute
2000-2005
University of Calabria
1996
University of Michigan
1994-1996
Journal Article Alterations in Hypothalamic Vasoactive Intestinal Peptide-Like Immunoreactivity Are Associated with Reproduction and Prolactin Release the Female Turkey Get access L. J. MAURO, MAURO 1Division of Animal Physiology, Department Science, University MinnesotaSt. Paul, Minnesota 55108; The Neuroscience Graduate Program, Cell Biology Neuroanatomy, Medical SchoolMinneapolis, 55414; Ecology Behavioral Biology, MinnesotaMinneapolis, 55414 Search for other works by this author on:...
Absence of the tyrosine kinase activity c-src and c-fins results in impairment bone remodeling.Such dysfunction underscores importance phosphorylation, yet role protein phosphatases metabolism remains unexamined.W e have isolated cDNA for a novel receptor-like phosphatase expressed testis named osteotesticular (OST-PTP).The deduced 1711-residue possesses an extracellular domain with 10 fibronectin type I11 repeats cytoplasmic region two catalytic domains.In pri- mary rat osteoblasts,...
We have capitalized on the unique properties of skin tumor promoter palytoxin, which does not activate protein kinase C, to investigate alternative mechanisms by major signaling molecules can be modulated during carcinogenesis. report here that palytoxin activates extracellular signal-regulated (ERK) through a novel mechanism involves inactivation an ERK phosphatase in keratinocytes derived from initiated mouse (308 cells). Use U0126 revealed requires MEK stimulate activity, although did...
Abstract A possible role of tri-iodothyronine (T 3 ) on the interplay between testicular steroids and Sertoli cells has been investigated basis previous findings demonstrating a direct inhibitory influence T aromatase activity oestradiol production in peripuberal cells. In this context, present study was focused effects oestrogen receptor (ER) androgen (AR) contents cytosol nucleus isolated from 2-, 3- 4-week-old euthyroid, hypothyroid treated rats. Hypothyroidism induced by oral...
Abstract Context The ability of ovarian steroids to modify cancer (OC) risk remains controversial. Progesterone is considered be protective; recent studies indicate no effect or enhanced OC risk. Knowledge progesterone receptor (PR) signaling during altered physiology that typifies development limited. Objective This study defines PR-driven oncogenic mechanisms in p53-mutant human fallopian tube epithelia (hFTE), a precursor the most aggressive subtype. Methods PR expression clinical samples...
Abstract Ovarian cancer (OC) represents a collection of rare but lethal gynecologic cancers where the difficulty early detection due to an often-subtle range abdominal symptoms contributes high fatality rates. With exception BRCA1/2 mutation carriers, OC most often manifests as post-menopausal disease, time in which ovaries regress and circulating reproductive hormones diminish. Progesterone is thought be “protective” hormone that counters proliferative actions estrogen, can observed uterus...
The premammillary nucleus (PMM) has been shown to contain a daily endogenous dual-oscillation in dopamine (DA)/melatonin (MEL) as well c-fos mRNA expression that is associated with the photo-inducible phase of gonad growth turkeys. In present study, clock genes (Bmal1, Clock, Cry1, Cry2, Per2 and Per3) PMM was determined under short (8 : 16 h light/dark cycle) long (16 8 photoperiods relative changes diurnal rhythm DA MEL. Constant darkness (0 24 used assess response genes. addition, light...
Abstract Background The bone-tumor microenvironment encompasses unique interactions between the normal cells of bone and marrow cavity malignant from a primary or metastasized cancer. A multitude paracrine factors within this such as growth factor, TGF-β, chemokine, MCP-1, are secreted by many these cell types. These can act in concert to modulate proliferation, migration invasion and, often, mediate cancer pain. Although valuable vitro vivo models exist, identifying relevant deciphering...
Bone remodeling requires regulated tyrosine phosphorylation mediated by specific protein kinases, such as c-src and c-fms, to date, unknown phosphatases (PTPs). We previously reported the isolation of a novel bone-specific receptor PTP, named osteotesticular PTP (OST-PTP), which is during osteoblast differentiation after exposure PTH. To determine relevance this PTH regulation, we characterized PTH-induced increase in OST-PTP messenger RNA (mRNA) UMR 106 cells comparison with effects on...
Leptin and the sympathetic nervous system have a unique role in linking nutritional status to skeletal metabolism mammals. Such regulatory mechanism has not been identified birds but would be beneficial signal information about energy reserves an organ essential for locomotion, reproduction, survival. To explore this potential of leptin birds, ex vivo chick tibiotarsal model was used test effects activity on longitudinal bone growth expression chondrocyte markers. Reverse transcription-PCR...
Serotonin and catecholamines (dopamine, norepinephrine, epinephrine) have important roles as neurotransmitters in avian reproduction, but their anatomical relationship to the neuroendocrine circuitry that regulates reproduction is poorly understood. Our previous studies shown co‐localised dopamine‐melatonin (DA‐MEL) neurones premammillary nucleus (PMM) are active during periods of photoresponsiveness and, therefore, potentially photosensitive neurones. Because serotonergic catecholaminergic...
Photoperiod is a major environmental cue in temperate-zone birds which synchronizes breeding with the time of year that offers optimal environment for offspring survival. Despite continued long photoperiods, these eventually become refractory to stimulating photoperiod and their reproductive systems regress. In this study, we characterized role γ-aminobutyric acid (GABA)ergic neurotransmission modulating response premammillary nucleus (PMM) gonad stimulatory onset...
The effects of thyroid hormone on androgen metabolism in peripuberal Sertoli cells through the inhibition estradiol production have been reported previously. It was our intention to investigate further possible role interaction between testicular steroids and by analyzing triiodothyronine (T3) estrogen receptor content 2-, 3- 4- week-old euthyroid rats. Triiodothyronine treatment (3 micrograms/100 body wt per day) given during last week prior sacrifice resulted reduced growth 2-week-old...
The in vitro mitogen response of whole blood turkey lymphocytes to various concentrations steroid hormones was evaluated. Corticosterone (COS) at between 1 and 80 ng/ml significantly suppressed the proliferative (3H-thymidine incorporation) phytohemagglutinin (PHA) concanavalin A (ConA). Non-mitogen-stimulated (NMS) cells were COS above 5 ng/ml. Progesterone NMS ng/ml, PHA-stimulated 500 ConA-stimulated 1000 beta-Estradiol enhanced had no effect on cells, greater than Testosterone affected...