A5088446602- Gut microbiota and health
- HIV Research and Treatment
- Tryptophan and brain disorders
- Mesenchymal stem cell research
- Respiratory viral infections research
- Influenza Virus Research Studies
- HIV-related health complications and treatments
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Health Education and Validation
- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- Animal Nutrition and Physiology
- Intensive Care Unit Cognitive Disorders
- Cannabis and Cannabinoid Research
- Infection Control and Ventilation
- Viral gastroenteritis research and epidemiology
- Regulation of Appetite and Obesity
- Body Contouring and Surgery
- Diabetic Foot Ulcer Assessment and Management
- Health and Lifestyle Studies
- Interdisciplinary Research and Collaboration
- Wound Healing and Treatments
- Clostridium difficile and Clostridium perfringens research
- Educational Strategies and Epistemologies
WinnMed
2021
Mayo Clinic
2018-2021
University of Minnesota
2010-2020
Medtronic (Ireland)
2018
Abstract Sepsis is the predominant cause of mortality in ICUs and opioids are preferred analgesic this setting. However, role sepsis progression has not been well characterized. The present study demonstrated that morphine alone altered gut microbiome selectively induced translocation Gram-positive bacteria mice. Using a murine model poly-microbial sepsis, we further treatment led to predominantly bacterial dissemination. Activation TLR2 by disseminated sustained up-regulation IL-17A IL-6....
Intestinal barrier dysfunction and subsequent microbial translocation play crucial roles in persistent immune activation leading to HIV disease progression. Opioid use is associated with worse outcome HIV-infected patients. The exacerbated progression by opioids mainly driven excessive intestinal inflammation increased gut permeability. objective of this study investigate how potentiate compromising function impairing epithelial self-repair mechanism. In the present study, abnormal...
Influenza is a global problem infecting 5–10% of adults and 20–30% children annually. Non-pharmaceutical interventions (NPIs) are attractive approaches to complement vaccination in the prevention reduction influenza. Strong cyclical absolute humidity has been associated with influenza outbreaks temperate climates. This study tested hypothesis that raising above seasonal lows would impact virus survival transmission key source distribution, community school. Air samples objects handled by...
Abstract Background Potent immunomodulatory effects have been reported for mesenchymal stem/stromal cells (MSCs), multipotent adult progenitor (MAPCs), and fibroblasts. However, side‐by‐side comparisons of these specifically regarding immunophenotype, gene expression, suppression proliferation CD 4 + 8 lymphocyte populations not reported. Methods We developed MAPC MSC lines from rhesus macaque bone marrow fibroblast cell dermis assessed phenotypes based upon differentiation potential, flow...
Leptin and the sympathetic nervous system have a unique role in linking nutritional status to skeletal metabolism mammals. Such regulatory mechanism has not been identified birds but would be beneficial signal information about energy reserves an organ essential for locomotion, reproduction, survival. To explore this potential of leptin birds, ex vivo chick tibiotarsal model was used test effects activity on longitudinal bone growth expression chondrocyte markers. Reverse transcription-PCR...
Wound healing is a goal for advanced technology in the surgical space to benefit clinical outcomes. Surgical staplers are commonly used variety of open and minimally invasive abdominal thoracic procedures. Assessment wound traits, such as perfusion, has been challenging due technical limitations. A novel technique that utilizes micro-computed tomography methodology measure perfusion was designed compare micro-perfusion staple lines between commercial stapler reloads employ different height...
Abstract Influenza is a global problem infecting 5-10 % of adults and 20-30 children annually. Non-pharmaceutical interventions (NPIs) are attractive approaches to complement vaccination in the prevention reduction influenza. Strong cyclical absolute humidity has been associated with influenza outbreaks temperate climates. This study tested hypothesis that raising above seasonal lows would impact virus survival transmission key source distribution, community school. Air samples objects...
To adapt to the increasingly technology-driven environment of modern K-12 education Integrated Science Education Outreach (InSciEd Out) digitized an extensive professional development curriculum library that forms core experience for teachers joining program. In previous years had been delivered solely in print form. The goals this conversion were better employ technology teacher training mirrored best practice their classrooms and provide a more scalable product InSciEd Out. was using...
Abstract Clinical observations show a strong correlation between microbial translocation and HIV disease progression. Chronic morphine, on its own, is known to induce bacterial translocation, impair immune activation pathogenic clearance during infection results in long-term persistent inflammation the affected organs. Lack of response therapy, non-AIDS related comorbidities have been linked as consequence translocation. The gut microbiota plays significant role maintaining homeostasis...
Abstract In the transplant community, natural suppressive cells derived from animals offer vast advantages over traditional chemical immunosuppressive agents that have very harsh side effects on both and patient. The bulk of this research has focused T regulatory (Tregs), given their known role quelling suppressing immune responses to infection. Other cells, such as mesenchymal stem (MSC), also been observed exert capabilities. As therapeutic immunomodulatory MSCs an advantage Tregs in they...