A5101787149- Gut microbiota and health
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Tryptophan and brain disorders
- Atmospheric chemistry and aerosols
- Photosynthetic Processes and Mechanisms
- interferon and immune responses
- HIV Research and Treatment
- Plant Stress Responses and Tolerance
- Pediatric health and respiratory diseases
- Gastrointestinal motility and disorders
- Air Quality and Health Impacts
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV/AIDS oral health manifestations
- Complement system in diseases
- Reproductive System and Pregnancy
- HIV-related health complications and treatments
- Extracellular vesicles in disease
- Pharmacological Receptor Mechanisms and Effects
- Intensive Care Unit Cognitive Disorders
Peking University
2024-2025
University of Miami
2017-2023
Shandong Academy of Agricultural Sciences
2006-2023
Sylvester Comprehensive Cancer Center
2017-2022
Liaocheng University
2020-2022
Zhengzhou University
2022
First Affiliated Hospital of Zhengzhou University
2020-2021
University of Minnesota
2011-2020
Jilin Agricultural University
2019
Xuzhou Central Hospital
2018
Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression gastrointestinal disorders limit their long-term use. In current study, a morphine-murine model was used to investigate role of gut microbiome metabolome potential mechanism contributing negative consequences associated with opioid Results reveal significant shift within one day following morphine treatment compared that observed...
Opiates are among the most prescribed drugs for pain management. However, morphine use or abuse results in significant gut bacterial translocation and predisposes patients to serious infections with origin. The mechanism underlying this defect is still unknown. In report, we investigated mechanisms compromised immune function following treatment. We demonstrate mesenteric lymph node (MLN) liver treatment wild-type (WT) animals that was dramatically significantly attenuated Toll-like receptor...
Prolonged exposure to opioids results in analgesic tolerance, drug overdose, and death. The mechanism underlying morphine tolerance still remains unresolved. We show that was significantly attenuated germfree (GF) pan-antibiotic-treated mice. Reconstitution of GF mice with naïve fecal microbiota reinstated tolerance. further demonstrated associated microbial dysbiosis selective depletion
Abstract Sepsis is the predominant cause of mortality in ICUs and opioids are preferred analgesic this setting. However, role sepsis progression has not been well characterized. The present study demonstrated that morphine alone altered gut microbiome selectively induced translocation Gram-positive bacteria mice. Using a murine model poly-microbial sepsis, we further treatment led to predominantly bacterial dissemination. Activation TLR2 by disseminated sustained up-regulation IL-17A IL-6....
Opioids such as morphine are widely used for the management of pain associated with acute pancreatitis. Interestingly, opioids also known to affect immune system and modulate inflammatory pathways in non-pancreatic diseases. However, impact on progression pancreatitis has never been evaluated. In current study, we evaluated severity pancreatitis.Effect treatment caerulein, L-arginine ethanol-palmitoleic acid models was after induction disease. Inflammatory response, gut permeability...
Intestinal barrier dysfunction and subsequent microbial translocation play crucial roles in persistent immune activation leading to HIV disease progression. Opioid use is associated with worse outcome HIV-infected patients. The exacerbated progression by opioids mainly driven excessive intestinal inflammation increased gut permeability. objective of this study investigate how potentiate compromising function impairing epithelial self-repair mechanism. In the present study, abnormal...
Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers resulting in persistent inflammation, septicemia and septic shock. Morphine was found down-regulate endotoxin/LPS induced miR-146a 155 macrophages. However, only over expression, but not miR-155 abrogates mediated hyper-inflammation. Conversely, antagonizing (but miR-155) heightened severity morphine-mediated These...
Peanut is one of the calciphilous plants. Calcium (Ca) serves as a ubiquitous central hub in large number signaling pathways. The effect exogenous calcium nitrate [Ca(NO3)2] (6 mM) on dissipation excess excitation energy photosystem II (PSII) antenna, especially level D1 protein and xanthophyll cycle peanut plants under heat (40°C) high irradiance (HI) (1 200 µmol m−2 s−1) stress were investigated. Compared with control [cultivated 0 mM Ca(NO3)2 medium], maximal photochemical efficiency PSII...
Sepsis continues to be a major problem for hospitalized patients. Opioids are widely used medications pain management despite recent evidence revealing their adverse effects. The present study evaluates survival differences between opioid-treated patients and non-opioid-treated with diagnosis of sepsis. Clinical data was extracted from the University Minnesota's Data Repository, which includes Electronic Health Records (EHRs) seen at 8 hospitals. Among 5,994 diagnosed sepsis, 4,540 1,454...
Abstract Background and Aims Opioids are the most prescribed analgesics for pain in inflammatory bowel diseases [IBD]; however, consequences of opioid use on IBD severity not well defined. This is first study investigating hydromorphone both dextran sodium sulphate [DSS]-induced colitis spontaneous (IL-10 knockout [IL-10-/-]) mouse models IBD. Methods To determine opioids pathogenesis, wild-type [WT] mice were treated with clinically relevant doses was induced via 3% DSS drinking water 5...
Abstract. Biomass burning (BB) is a significant source of dicarboxylic acids (diacids) and related compounds that play important roles in atmospheric chemistry climate change. In this study, combustion chamber oxidation flow reactor were used to generate fresh aged aerosols from burned rice, maize wheat straw investigate aging the stable carbon isotopic (δ13C) composition these emissions. Succinic acid (C4) was most abundant species samples, while oxalic (C2) became dominant after aging. Of...
There has been a rapid increase in neonates born with history of prenatal opioid exposure. How exposure affects pain sensitivity offspring is interest, as this may perpetuate the epidemic. While few studies have reported hypersensitivity to thermal pain, potential mechanisms not described. This study posits that alterations gut microbiome underly prenatally methadone-exposed 3-week-old male offspring, which were generated using mouse model methadone Fecal samples collected from dams and...
Invasive infections by encapsulated bacteria are the major cause of human morbidity and mortality. The liver resident macrophages, Kupffer cells, form hepatic firewall to clear many in blood circulation but fail control certain high-virulence capsule types. Here we report that spleen is backup immune organ liver-resistant serotypes Streptococcus pneumoniae (pneumococcus), a leading pathogen. Asplenic mice failed growth pneumococci circulation. Immunologic genetic analyses identified splenic...
Chronic drug users account for a third of all cases AIDS in the United States and progression to dementia is accelerated opiate abusers. Clinically, microglial activation better correlates with HIV-associated neurocognitive disorders (HAND) than productive HIV-1 infection CNS. Moreover, pneumococcal pneumonia most common opportunistic individuals HAND. We show that coinfection <i>Streptococcus pneumoniae</i> may be contributing factor increased prevalence HAND opioid-dependent population. To...
ABSTRACT The spleen is well-known for defense against invasive infections of encapsulated bacteria, particularly Streptococcus pneumoniae (pneumococcus). However, the precise mechanism splenic anti-bacterial immunity remains elusive. Here we report that red pulp (RP) macrophages execute S. in mice, with help natural antibodies (nAbs) and complement system. slowly but substantially cleared pneumococci from bloodstream early phase blood infection, especially serotypes resist to liver...
Abstract A known Arabidopsis cDNA clone, the CRT/DRE binding factor 1 ( CBF1 ), was isolated and introduced into tomato plants. is a member of CBF gene family related to low temperature enhanced tolerance in In present work, transcripts could be detected transgenic leaves, photochemical efficiency PSII (F v /F m ) oxidisable P700 over‐expressing were higher than non‐transformed plants under stress at irradiance. Similarly, activity superoxide dismutase (SOD), non‐photochemical quenching...