A5055863552- Barrier Structure and Function Studies
- Single-cell and spatial transcriptomics
- Alzheimer's disease research and treatments
- Advanced Drug Delivery Systems
- Olfactory and Sensory Function Studies
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Conferences and Exhibitions Management
- Diet and metabolism studies
- Lipid Membrane Structure and Behavior
- S100 Proteins and Annexins
- Dementia and Cognitive Impairment Research
- Vagus Nerve Stimulation Research
- Metabolomics and Mass Spectrometry Studies
- Health Systems, Economic Evaluations, Quality of Life
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Artificial Intelligence in Healthcare and Education
- Social Media in Health Education
University of Kentucky
2021-2025
University of Wisconsin–Madison
2018-2021
Blood–brain barrier dysfunction is one characteristic of Alzheimer's disease (AD) and recognized as both a cause consequence the pathological cascade leading to cognitive decline. The goal this study was assess markers for in postmortem tissue samples from research participants who were either cognitively normal individuals (CNI) or diagnosed with AD at time autopsy determine what extent these are associated neuropathologic changes (ADNC) impairment. We used brain plasma 19 participants: 9...
Abstract Aims We sought to identify and optimise a universally available histological marker for pericytes in the human brain. Such could be useful tool researchers. Further, identifying gene expressed relatively specifically provide new insights into biological functions of this fascinating cell type. Methods analysed single‐cell RNA expression profiles derived from different mouse brain regions using high‐throughput low‐cost transcriptome sequencing method called EasySci. Through analysis,...
Objective The goal of the study was to identify potential nutrigenetic effects inulin, a prebiotic fiber, in mice with different human apolipoprotein E (APOE) genetic variants. Specifically, we compared responses inulin for modulation systemic metabolism and neuroprotection via gut-brain axis APOE ϵ3 ϵ4 alleles.Method We performed experiments young expressing APOE3 (E3FAD APOE4 gene (E4FAD mice). fed either or control diet 16 weeks starting from 3 months age. determined gut microbiome...
Abstract Background Patients with Alzheimer's disease (AD) develop blood–brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, function, and cognitive decline in AD remains largely unknown. In this study, we used 5xFAD mice investigate changes levels, over time. Methods wild-type (WT) were aged between 9.5 15.5 months tested for spatial learning reference memory the Morris Water Maze (MWM). After behavior testing, implanted acute cranial windows intravenously injected...
Abstract Perillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route administration preferred dosing POH in early-stage clinical trials associated with promising outcomes cancer. However, it is unclear how targets tumors these patients. Multiple studies indicate that intranasally applied large molecules may enter cerebrospinal fluid (CSF) through direct olfactory trigeminal nerve-associated pathways originating nasal...
Passive immunotherapy has become a prominent therapeutic strategy for the treatment of many different neurological disorders. Antibodies can be targeted to pathogenic proteins diseases such as Alzheimer's (e.g., beta‐amyloid and phosphorylated tau), Parkinson's alpha‐synuclein), multiple sclerosis CD20 marker on B cells). However, delivery antibodies central nervous system (CNS) following systemic administration is significantly impeded result blood‐brain barrier (BBB)...
Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field, several international exist that allow researchers to present data, share knowledge, discuss novel ideas concepts. These meetings critical platforms connect exchange breakthrough findings on a regular basis. Due worldwide COVID-19 pandemic, all in-person were canceled 2020. response, we launched Brain Barriers Virtual 2020 (BBV2020)...
Objective: Cerebral cavernous malformation type III (CCM3) is associated with null mutations in programmed cell death 10 (PDCD10 or CCM3) and characterized by vessel dilation increased bloodbrain barrier (BBB) permeability, leading to cerebral hemorrhage.Our lab demonstrated that the absence of CCM3 a mouse brain microvascular endothelial (mBEC) line leads connexin 43 (Cx43) expression, gap tight junction (TJ) remodeling, permeability.Absence also expression 20 kDa Cx43 isoform (20-Cx43).Our...
Alzheimer’s disease (AD) is the most common form of dementia. AD brain pathology starts decades before onset clinical symptoms. One early pathological hallmark blood-brain barrier dysfunction characterized by leakage and associated with cognitive decline. In this review, we summarize existing literature on extent relevance in AD. First, focus animal models their susceptibility to based age genetic background. Second, re-examine postmortem studies, changes that lead patients highlight Third,...