Copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) is an essential "click chemistry" reaction that widely used in chemical biology, medicinal chemistry and materials science. The CuAAC of terminal alkynes provides a mild efficient synthesis 1,4-disubstituted 1,2,3-triazoles. However, the click internal with azides, giving trisubstituted triazoles, very challenging. This feature article highlights recent progress addressing this fundamental problem. Particular emphasis on current emerging...

New types of [2.2]paracyclophane derivatives, g-BNMe2-Cp and m-BNMe2-Cp, in which electron-donating NMe2 the electron-accepting BMes2 are introduced at pseudo-gem pseudo-meta positions, were designed synthesized. The efficient through-space charge transfer enables intense fluorescence with thermally activated delayed characteristics. quantum yields up to 0.72 0.39 cyclohexane. In addition, no significant quenching was observed solid state powder 0.53 0.33. Moreover, enantiomerically pure...

An efficient electrophilic persulfuration reaction leading to unsymmetrical disulfides and polysulfides has been developed. Various nucleophiles, including aryl boronic acids, β-keto esters, thiols, can be used as substrates. The notable features of this method include very simple practical conditions, general scope, inexpensive copper catalysts.

Chiral N-heterocyclic carbene ligands based on [2.2]paracyclophanes form complexes with rhodium. These catalysts can be used in the high-yielding and enantioselective asymmetric conjugate addition of arylboron compounds to cyclic acyclic enones (see scheme). Supporting information for this article is available WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z52679_s.pdf or from author. Please note: The publisher not responsible content functionality any supporting supplied by...

A Cu/Pd-catalyzed, three-component click reaction of azide, alkyne, and aryl halide has been developed. By using this Cu/Pd transmetalation relay catalysis, a variety 1,4,5-trisubstituted 1,2,3-triazoles were quickly assembled in one step high yields with complete regioselectivity, just like assembling Lego bricks. Notably, different from the well-established CuAAC reactions only working on terminal alkynes, offers an alternative solution for problem internal alkynes.

A copper(I)-catalyzed tandem CuAAC/alkynylation reaction of various alkynes, organic azides, and bromoalkynes to provide rapid access 5-alkynyl-1,2,3-triazoles has been developed. The proceeded via a copper-catalyzed alkyne azide cycloaddition followed by interception the in situ formed cuprate–triazole intermediate with bromoalkyne. This offers new method afford fully substituted triazoles high yields complete regioselectivity under mild conditions.

A copper(I)-catalyzed three-component CuAAC/persulfuration reaction providing rapid access to asymmetric triazole disulfides has been developed. The interrupted click shows broad substrate scope, complete regioselectivity, and excellent functional group tolerability.

Metalated triazoles are the key reactive intermediate of current click reaction (CuAAC). Bench-stable 5-stannyl obtained by a copper-catalyzed interrupted easily available terminal alkynes. Subsequent palladium-catalyzed cross-coupling reactions, electrophilic trifluoromethylthiolation and trifluoromethylation, generate diverse 1,4,5-trisubstituted efficiently, which traditional is unable to do.

Bulky phenanthracenyl imidazolium-derived carbene ligands were investigated for copper-free Sonogashira coupling with terminal acetylenes. Aryl bromides and iodides gave coupled products in excellent yields from the Pd(PPh3)2Cl2 complex potassium t-butoxide 18-crown-6 THF. A remarkable dependence on size of ligand was found. The highest obtained bulky 2,9-dicyclohexyl-10-phenanthryl 5.

An efficient copper-catalyzed asymmetric conjugate boration has been achieved by exploiting a new planar and central chiral bicyclic triazolium ligand. This protocol was highly gave variety of secondary alkylboronates in 97–99% ee. A preliminary mechanistic study supports the bifunctional nature catalyst.

The abundance, spatial distribution of and dynamic changes in ichthyoplankton species affect the recruitment fish population dynamics, which are fundamental for stock assessment fisheries management. An evaluation alternative sampling designs needs to be carried out determine optimal scheme that is cost-effective collecting high-quality data. A simulation study was conducted evaluate performances consistency six potential an survey coastal waters central southern Yellow Sea. Relative...

Climate change is a major challenge affecting marine environments, making it essential to understand species distribution responses in both time and space for effective conservation strategies. Meanwhile, varying of climate may lead changes interspecific relationships future spatial distributions. This study assessed temporal distributions four trophically dependent economic importance the China seas, including largehead hairtail (Trichiurus lepturus), Spanish mackerel (Scomberomorus...

The sustainable exploitation of fishery resources in Pakistan was assessed using the catch-based Monte Carlo method (CMSY) and length-based Bayesian biomass (LBB) to evaluate data-limited Spangled Emperor, Lethrinus nebulosus. CMSY relies on catch data, resilience parameters, quantitative stock status metrics, while LBB exclusively uses length–frequency (LF) data for assessments. This study utilized twenty-two years catch–effort LF from 7230 fish along Balochistan coastline Pakistan....

A new planar and centrally chiral bicyclic 1,2,4-triazolium salt has been synthesized from [2.2]paracyclophane phenylglycinol. The N-heterocyclic carbene (NHC) copper(I) complex generated in situ by the reaction of triazolium Cu2O was an efficient catalyst for asymmetric β-boration acyclic enones, producing β-boryl ketones high yields enantioselectivities.

A series of new oxazoline-substituted imidazolium salts based on [2.2]paracyclophane were synthesized and characterized. The bidentate oxazoline-carbene precursor with planar central chirality had significant advantage than the bicyclic 1,2,4-triazolium salt derived from as a monodentate carbene ligand in Cu(I)-catalyzed asymmetric β-boration α,β-unsaturated esters, giving desired products high enantioselectivities yields.

Abstract Catalytic enantioselective C–C bond forming process through cross-dehydrogenative coupling represents a promising synthetic strategy, but it remains long-standing challenge in chemistry. Here, we report formal catalytic of saturated ethers with diverse carboxylic acid derivatives involving an initial oxidative acetal formation, followed by nickel(II)-catalyzed asymmetric alkylation. The one-pot, general, and modular method exhibits wide compatibility broad range not only including...

[reaction: see text] A highly efficient catalytic borylation process with aryldiazonium ions was developed using a carbene-palladium catalyst formed in situ to give arylpinacolatoborane products. An X-ray structure for the N-heterocyclic complex, used as from bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium chloride, obtained without added base.