A5027075360- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Marine and coastal ecosystems
- Geochemistry and Elemental Analysis
- Paleontology and Stratigraphy of Fossils
- Plant Micronutrient Interactions and Effects
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- TGF-β signaling in diseases
- Growth Hormone and Insulin-like Growth Factors
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Phytase and its Applications
- Cancer Immunotherapy and Biomarkers
- Aquatic and Environmental Studies
- Caveolin-1 and cellular processes
- Proteoglycans and glycosaminoglycans research
- Chromium effects and bioremediation
- Invertebrate Immune Response Mechanisms
- Effects of Radiation Exposure
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
San Diego State University
2012-2025
Nanostring Technologies (United States)
2020
Augusta University
2006-2018
University of San Diego
2015
Virtua Memorial Hospital
2004-2009
Edinburgh Cancer Research
2003-2006
Memorial Hospital of South Bend
2005
Western General Hospital
1992-2003
Cancer Research UK
2001-2003
University of Edinburgh
1988-1998
This study examined the efficacy of a couple-focused group intervention on psychological adaptation women with early stage breast cancer and evaluated whether perceived partner unsupportive behavior or patient functional impairment moderated effects. Two hundred thirty-eight were randomly assigned to receive either 6 sessions usual care. Intent-to-treat growth curve analyses indicated that participants couples' reported lower depressive symptoms. Women rating their partners as more benefited...
The majority of ovarian cancer patients are treated with platinum-based chemotherapy, but the emergence resistance to such chemotherapy severely limits its overall effectiveness. We have shown that development this treatment can modify cell signaling responses in a model system wherein cisplatin has altered responsiveness ligands erbB receptor family. A cisplatin-resistant carcinoma line PE01CDDP was derived from parent PE01 by exposure increasing concentrations cisplatin, eventually...
Iron is an essential element for all living organisms due to its ubiquitous role in redox and other enzymes, especially the context of respiration photosynthesis. The iron uptake storage systems terrestrial/higher plants are now reasonably well understood, with two basic strategies being distinguished: strategy I use a mechanism involving induction Fe(III)-chelate reductase (ferrireductase) Fe(II) transporter proteins, while II utilize high-affinity, iron-specific, binding compounds called...
This study explores key features of bromine and iodine metabolism in the filamentous brown alga genomics model Ectocarpus siliculosus. Both elements are accumulated Ectocarpus, albeit at much lower concentration factors (2-3 orders magnitude for iodine, < 1 order bromine) than e.g. kelp Laminaria digitata. Iodide competitively reduces accumulation bromide. iodide bromide cell wall (apoplast) with minor amounts also detectable cytosol. emits a range volatile halogenated compounds, most...
Several methods exist for the detection of apoptosis using features cell as it undergoes various stages leading to death (1,2). One earliest uses flow cytometry was detecting a sub-G0 peak in DNA histogram that showed fragmentation nucleus (3). The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay also detects by broken ends sequences with fluorescein isothiocynate conjugate (FITC)-labeled nucleotides (4,5). Unfortunately, occurs at late stage process (6)...
In contrast to the generally boron-poor terrestrial environment, concentration of boron in marine environment is relatively high (0.4 mM) and while there has been extensive interest its use as a surrogate pH paleoclimate studies context climate change-related questions, depth independent, non-nutrient-like profile this element have led being neglected potentially biologically relevant ocean. Among plant-like organisms brown algae (Phaeophyta) are one only five lineages photosynthetic...
Although the iron uptake and storage mechanisms of terrestrial/higher plants have been well studied, corresponding systems in marine algae received far less attention. Studies shown that while some species unicellular utilize unique uptake, many acquire through same general as higher plants. In contrast, acquisition strategies multicellular macroalgae remain largely unknown. This is especially surprising since these organisms represent important ecological evolutionary niches coastal...
// Robert J. Schleifer 1 , Shuchun Li Wyatt Nechtman Eric Miller Shan Bai Ashok Sharma 1, 2 and Jin-Xiong She 3 Center for Biotechnology Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA Department Biostatistics Epidemiology, Obstetrics Gynecology, Correspondence to: She, email: jshe@augusta.edu Keywords: KLHL; KLHL5; cell cycle; combined therapy; synergistic effects Received: February 19, 2018 Accepted: December 05,...
Abstract Mutated epidermal growth factor receptor (EGF-RvIII, ΔEGF-R, and de2–7 EGF-R) is the result of an 801-bp deletion within extracellular domain wild-type EGF-R expressed by breast carcinomas, but not normal tissues. EGF-RvIII both on surface in cytoplasm tumor cells. Thus, a potential tumor-specific target for Abs T However, it known whether cancer patients can raise immune responses to their tumors. The demonstration EGF-RvIII-specific would suggest that immunization with vaccines...
Abstract Iron is an essential element for all living organisms due to its ubiquitous role in redox and other enzymes, especially the context of respiration photosynthesis. Although iron uptake storage mechanisms terrestrial/higher plants have been well-studied, corresponding systems marine algae received far less attention. While many take up from environment, irrespective detailed internalization mechanism, arrives at cell surface by diffusion, there growing evidence more “active” means...
The monoclonal antibodies F8-11-13, 4KB5, MB1, and MB2 recognize largely B-cell-restricted antigenic determinants that resist routine processing. Similarly, MT1, MT2, UCHL1 react with fixation-resistant T-cell-restricted antigens. In order to evaluate the diagnostic potential of these antibodies, authors have assessed their immunoreactivity a series 81 formalin-fixed paraffin-embedded non-Hodgkin's lymphomas (48 B-cell, 33 T-cell) encompassing wide variety histologic subtypes, which had been...
Immunotherapy of colorectal carcinoma (CRC) has great promise as the presence T lymphocytes in CRC tissues situ is correlated with reduced recurrence and increased survival. Thus, identification antigens recognized by cells patients may permit development vaccines potential benefit for these patients. Using expression cloning, we identified antigen, nucleophosmin (Npm), an HLA-A1 restricted cytotoxic lymphocyte (CTL) line derived from peripheral blood mononuclear (PBMC) a rectal cancer...