A5064127799- Transplantation: Methods and Outcomes
- Fungal Infections and Studies
- HIV/AIDS drug development and treatment
- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
University of California, San Francisco
2022-2024
Limited data and guidelines exist for using nirmatrelvir/ritonavir in solid organ transplant recipients stabilized on tacrolimus the treatment of mild-to-moderate coronavirus disease. Concern exists regarding impact utilizing a 5-d course with calcineurin inhibitors because significant drug-drug interactions between ritonavir, potent cytochrome P450 3A inhibitor, other substrates, such as tacrolimus.We report successful use 12 outpatient lung confirmed severe acute respiratory syndrome 2...
Invasive fungal infections can cause serious complications after lung transplant; therefore, prophylaxis with posaconazole is common. The delayed-release (DR) tablet preferred. Although the package insert states DR tablets cannot be crushed, recent data suggest it reasonable. We hypothesized that crushed could reach therapeutic levels in transplant recipients.