A5103974967- Risk and Safety Analysis
- Occupational Health and Safety Research
- Diverse Educational Innovations Studies
- Eosinophilic Esophagitis
- interferon and immune responses
- Inflammatory Bowel Disease
- Cytokine Signaling Pathways and Interactions
- Indigenous and Place-Based Education
- Educational Assessment and Pedagogy
- Eosinophilic Disorders and Syndromes
- Fungal Infections and Studies
- Engineering Education and Pedagogy
- Adolescent and Pediatric Healthcare
- Viral Infections and Immunology Research
- Science Education and Perceptions
- Structural Integrity and Reliability Analysis
- Digital Storytelling and Education
- Inflammatory Myopathies and Dermatomyositis
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Systemic Lupus Erythematosus Research
- Helicobacter pylori-related gastroenterology studies
- Outsourcing and Supply Chain Management
- Digital Marketing and Social Media
- Pregnancy and Medication Impact
University of California, San Francisco
2024-2025
University of Pittsburgh
2024
University of Pittsburgh Medical Center
2023
University of Southern California
2015
Robert Gordon University
1996
<h3></h3> In lupus, TLR7 and TLR9 mediate loss of tolerance to RNA DNA, respectively. Yet, promotes while protects from disease, implying differences in signaling. To dissect this 'TLR paradox', we generated two point mutants—lacking either ligand (TLR9K51E) or MyD88 (TLR9P915H) binding—in lupus-prone MRL/lpr mice. Ameliorated disease <i>Tlr9</i>K51E mice compared <i>Tlr9</i>-/- controls revealed a 'scaffold' protective function that is ligand- MyD88-independent. Unexpectedly,...
Invasive fungal infections can cause serious complications after lung transplant; therefore, prophylaxis with posaconazole is common. The delayed-release (DR) tablet preferred. Although the package insert states DR tablets cannot be crushed, recent data suggest it reasonable. We hypothesized that crushed could reach therapeutic levels in transplant recipients.
Introduction: Global epidemiological trends suggest that inflammatory bowel disease (IBD) is associated with industrialization but few studies have specifically evaluated urban exposure in early life. Our aim was to evaluate the impact of population density place birth on phenotype and severity IBD. Methods: From 2010-2014, IBD patients were enrolled a prospective cohort study at single center serving major metropolitan area large Hispanic population. Patients completed questionnaire...
Introduction: Genome-wide association studies have identified 163 susceptibility loci for inflammatory bowel disease (IBD) in Caucasian corhorts. Our aim was to evaluate ATG16L1, IL23R, and NOD2 variants a largely Hispanic cohort the U.S.Table 1: Minor Allele Frequencies (MAFs)Methods: IBD patients ethnically-matched controls were recruited 1:1 ratio at single center major US metropolitan with large population. Genomic DNA isolated following nucleotide polymorphisms (SNPs) analyzed: ATG16L1...
Risk Perception and Safety in the UK Offshore Oil Gas Industry Rhona H. Flin; Flin The Robert Gordon University Search for other works by this author on: This Site Google Scholar Kathryn Mearns; Mearns Rachael P.E. Gordon; Mark T. Fleming Paper presented at SPE Health, Environment Exploration Production Conference, New Orleans, Louisiana, June 1996. Number: SPE-35907-MS https://doi.org/10.2118/35907-MS Published: 09 1996 Cite View Citation Add to Manager Share Icon Twitter LinkedIn Get...
<h3>Background</h3> Toll like receptors (TLR) 7 and 9, endosomal sensors for ssRNA dsDNA, are key mediators of lupus autoreactivity. Although considered homologous, they have opposing effects on severity: TLR7 exacerbates disease while TLR9 protects. One theory is that induces protection by competing with trafficking, thus restraining expression signaling. However, since both ligands available in lupus, TLRs supposed to signal via MyD88, this doesn't explain the differential two disease. To...