A5114348262- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac tumors and thrombi
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Congenital Heart Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Blood transfusion and management
- Cardiovascular Issues in Pregnancy
- Cardiac pacing and defibrillation studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiovascular Effects of Exercise
- Pericarditis and Cardiac Tamponade
- Pulmonary Hypertension Research and Treatments
Centro Cardiologico Monzino
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2000-2024
University of Milan
2012-2021
Karolinska Institutet
2019
Karolinska University Hospital
2019
Mylan (Switzerland)
2018
Milano University Press
2018
Glenfield Hospital
2018
Istituto Superiore di Sanità
2018
Magna Graecia University
2018
Atrial fibrillation (AF) after coronary artery bypass graft surgery is a difficult problem and continuing source of morbidity mortality. However, the prognostic implications postoperative AF are still in dispute. Our aim was to ascertain impact on survival assess its role cause-specific mortality.We conducted prospective observational study 1832 patients undergoing isolated between January 2000 December 2005 at 2 cardiac centers northern Italy. Patients affected by were identified followed...
Background Atrial fibrillation ( AF ) remains the most common complication after cardiac surgery. The present study aim was to derive an effective bedside tool predict postoperative and its related complications. Methods Results Data of 17 262 patients undergoing adult surgery were retrieved at 3 European university hospitals. A risk score for POAF score) derived validated. In overall series, 4561 (26.4%) developed . derivation cohort age, chronic obstructive pulmonary disease, emergency...
Background —Excessive bleeding may complicate congenital cardiac defects. To explain the pathogenesis of this abnormality, we evaluated selected parameters primary hemostasis in patients with aortic valve stenosis before and after corrective surgery. Methods Results —We examined shear-induced platelet aggregation filter aggregometer test von Willebrand factor (vWF) structure by evaluating multimeric distribution extent subunit proteolysis. The count was reduced surgery, impaired. Moreover,...
The aim of this study was to assess the impact frailty on outcome after coronary artery bypass grafting (CABG) and whether it may improve predictive ability European System for Cardiac Operative Risk Evaluation (EuroSCORE II).The Clinical Frailty Scale (CFS) assessed preoperatively in patients undergoing isolated CABG from multicentre E-CABG registry, were stratified into 3 classes: scores 1-2, 3-4 5-7.Of 6156 enrolled, 39.2% had CFS 57.6% 3-4, 3.2% 5-7. Logistic regression adjusted multiple...
The optimal timing of discontinuation ticagrelor before cardiac surgery is controversial.To evaluate the safety preoperative use with or without aspirin in patients acute coronary syndromes (ACS) undergoing isolated artery bypass grafting (CABG) compared alone.This prospective, multicenter clinical trial was performed at 15 European centers surgery. Participants were ACS CABG from Multicenter Study on Coronary Artery Bypass Grafting (E-CABG) registry between January and September 2015.Before...
Echocardiographic reduction of RV function, measured using TAPSE, is a well described phenomenon after cardiac surgery. The aim the present study was to investigate relation between modality pericardial opening (lateral versus anterior) and postoperative right ventricular systolic function by comparing echocardiographic parameters in patients undergoing minimally invasive or traditional mitral valve repair. 34 with severe regurgitation due prolapse underwent (sternotomy) operation (Group A)...
Background Calcific aortic valve stenosis (AS) affects 3% of older adults and lacks medical treatment. The deacetylase Sirtuin 1 (SIRT1) could be involved in many pathways linked to AS progression. Sodium-glucose co-transporter 2 inhibitors (SGLT2i), glucose-lowering agents, have been shown reduce cardiovascular events (likely via SIRT1), but their possible benefits are unknown. Our study aims uncover the role SIRT1 progression assess benefit SGLT2i slow down fibro-calcification processes....
The reduction of RV function after cardiac surgery is a well-known phenomenon. It could persist up-to one year the operation and often leads to an incomplete recovery at follow-up echocardiographic control. aim present study analyze impact different modalities pericardial incision (lateral versus anterior) myocardial protection protocols (Buckberg Custodiol) onto postoperative dynamic by relating two- three-dimensional parameters in patients undergoing mitral valve repair through minimally...
AimsThe aim of this study, undertaken in patients who underwent mitral valve (MV) repair surgery, was to evaluate the accuracy pre-operative three-dimensional (3D) transthoracic echocardiography (TTE) evaluation MV pathology cases with simple or complex lesions.
The aim of this study was to evaluate the impact red blood cell (RBC) transfusions on occurrence stroke and transient ischaemic attack (TIA) after cardiac surgery.Data 14 956 patients undergoing coronary artery bypass grafting (CABG) valve surgery (with or without concomitant CABG) were retrieved at three European University Hospitals. prognostic RBC transfusion postoperative TIA investigated by logistic regression multilevel propensity score analysis.Postoperative observed in 147 (1.0%)...
Atrial fibrillation (AF) is the most common arrhythmia and its prevalence increasing due to progressive aging of population. About 20% strokes are attributable AF patients at five-fold increased risk stroke. The mainstay treatment prevention thromboembolic complications with oral anticoagulation therapy. Drug for many years has been based on use vitamin K antagonists, but recently newer safer molecules have introduced (dabigatran etexilate, rivaroxaban, apixaban, edoxaban). Despite these...
The Pall Celeris system is a filtration-based point-of-care device designed to obtain high concentrate of peripheral blood total nucleated cells (PB-TNCs). We have characterized the Celeris-derived TNCs for their in vitro and vivo angiogenic potency.PB-TNCs isolated from healthy donors were through use flow cytometry functional assays, aiming assess migratory capacity, ability form capillary-like structures, endothelial trans-differentiation paracrine factor secretion. In hind limb ischemia...