A5102893877- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cell Image Analysis Techniques
- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Urologic and reproductive health conditions
- MicroRNA in disease regulation
- Fetal and Pediatric Neurological Disorders
- Autopsy Techniques and Outcomes
- Ocular Oncology and Treatments
- Gastrointestinal disorders and treatments
- Vascular Tumors and Angiosarcomas
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Atherosclerosis and Cardiovascular Diseases
- Hepatitis C virus research
- Venous Thromboembolism Diagnosis and Management
- Cutaneous Melanoma Detection and Management
- Lipid metabolism and disorders
- Advanced Biosensing Techniques and Applications
- Colorectal and Anal Carcinomas
- Diagnosis and Treatment of Venous Diseases
- Medical Imaging Techniques and Applications
Iuliu Hațieganu University of Medicine and Pharmacy
2009-2024
University of Medicine and Pharmacy of Craiova
2024
Spitalul Clinic Județean de Urgență Cluj-Napoca
2019-2022
County Hospital
2020
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2008-2011
Lung cancers are broadly divided into two categories: non-small-cell lung carcinoma (NSCLC), which accounts for 80–85% of all cancer cases, and small-cell (SCLC), covers the remaining 10–15%. Recent advances in biology genomics research have allowed an in-depth characterization that revealed new therapy targets (EGFR, ALK, ROS, KRAS mutations) potential revealing even more biomarkers diagnostic, prognostic, targeted therapies. A source is represented by non-coding RNAs, especially microRNAs...
Inflammation and hyperlipidemia play an essential role in the pathophysiology of endothelial dysfunction as well atherosclerotic plaque formation, progression rupture. Colchicine has direct anti-inflammatory effects by inhibiting multiple inflammatory signaling pathways. The purpose our study was to evaluate colchicine activity animal model induced diet. A total 24 male rats (wild type, WT) were divided into three groups: group one fed with a basic diet (BD) (WT + BD,
Glioblastoma multiforme (GBM) represents a very aggressive brain tumor. Angiogenesis is the formation of network new blood vessels, from preexisting ones. It plays an important role in tumor, as it supplies with oxygen
Aim: Endoscopic ultrasound (EUS) has become an indispensable method for diagnosis in gastroenterology and new indications EUS continue to emerge. However, there are limited data regarding the accuracy of EUS-guided biopsy hepatic focal lesions. The aim this study was assess diagnostic yield fine needle aspiration (FNA) liver lesions.Material methods: We conducted a prospective which patients with lesions, detected by transabdominal computed tomography or magnetic resonance imaging, underwent...
Background and objectives: The pineal gland is a photoneuroendocrine organ in the midline of brain, responsible primarily for melatonin synthesis. It composed mainly pinealocytes glial tissue. This study examined human postmortem glands to microscopically assess age-related changes using digital techniques, offers perspective on evolutionary tendencies compared past. Materials Methods: A retrospective autopsy has been performed 72 pediatric adult cases. have processed histological analysis...
PRAME (PReferentially expressed Antigen in Melanoma) immunohistochemistry has proven helpful distinguishing malignant from benign melanocytic tumors. We studied IHC expression 46 thin melanomas and 39 nevi, mostly dysplastic nevi. Twenty-six percent (26.09%) of the showed diffuse staining over 76% tumor cells (4+), 34.78% 51% (3+ or 4+), while 8% were entirely negative for PRAME. No nevi 4+ 3+. More than half (64%) staining, 36% 1-25% (1+) 26-50% (2+). stained with a color intensity 3,...
Glioblastoma multiforme is a very aggressive brain tumor. Angiogenesis, the formation of new blood vessels from pre-existing ones, process that plays an essential role in cancer development. The evolution this depends upon several proangiogenic factors as well inhibitors angiogenesis. Coagulation and inflammation also play important tumorigenesis. Their expression controlled by over- or under-expression certain genes. objective our study was to evaluate expression, tissue samples, set six...
In spite of the multimodal treatment used today, glioblastoma is still most aggressive and lethal cerebral tumour. To increase survival in these patients, novel therapeutic targets must be discovered. Signal transducer activator transcription 3 (Stat3), a factor that controls normal cell differentiation also involved neoplastic celltransformation. this study we evaluated immunohistochemical expression pY705-Stat3 patients with primary determined its prognostic role by correlating it...
ABSTRACT Angiomatosis or diffuse hemangioma is a very rare benign vascular tumor, consisting of blood and lymphatic channels growing diffusely in the breast parenchyma. We report case angiomatosis 34‐year‐old woman with pubertal anisomastia. Ultrasound raised suspicion by showing large cystic spaces separated septae moderate flow, similar to those found lymphangioma. discuss imaging (mammography, ultrasound, MRI) pathologic findings, brief review literature. © 2014 Wiley Periodicals, Inc. J...
Introduction: Histological grading of cutaneous squamous cell carcinoma (cSCC) is crucial for prognosis and treatment decisions, but manual subjective time-consuming. Aim: This study aimed to develop validate a deep learning (DL)-based model automated cSCC grading, potentially improving diagnostic accuracy (ACC) efficiency. Materials Methods: Three neural networks (DNNs) with different architectures (AlexNet, GoogLeNet, ResNet-18) were trained using transfer on dataset 300 histopathological...
Mondor's disease is a rare condition, which involves the thrombophlebitis of superficial veins breast and anterior chest wall. A 37-year-old woman presented with sudden onset local pain edema on her right wall, accompanied by longitudinal retraction skin during arm abduction in area. Clinical, histological ultrasonographic findings confirmed treatment was symptomatic, using relievers warm compresses. The symptomatology remitted within 2 weeks therapy. condition where ultrasound complements...
The examination of very small fetal hearts requires special equipment and a specialist that are not available in many general pathology laboratories. Compared to conventional examination, the four-chamber cardiac dissection (4CCD) method can be performed by any pathologist using instruments generally services. aim this study is evaluate efficiency 4CCD post-mortem magnetic resonance imaging (pm-MRI) at 7T as standard. Twelve fetuses with gestational ages between 13 19 weeks have been...
Genes included in apoptosis may be involved tumor biology and identify specific groups of patients with individual therapy. The aim this study was to evaluate the prognostic value some markers conjunction pathological factors operable rectal cancer patients.Tumor samples from 87 adenocarcinoma were analyzed retrospectively. immunohistochemistry 'tissue array' for expression p53, p21, Bcl-2 cycline D1, combined features correlated survival data. mean postoperative follow-up 48...
Abstract The pineal gland is a small‐sized, photo neuroendocrine organ in the midline of brain that synthesises and secretes melatonin serotonin. Chords islands pinealocytes constitute secretory parenchyma, while glial tissue calcifications represent degenerative changes. This study examined human postmortem glands to microscopically assess morphological changes possibly associated with clinical data, by using digital techniques. A retrospective autopsy has been performed on 72 paediatric...