A5103056905- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Parasites and Host Interactions
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Parasitic infections in humans and animals
- Systemic Lupus Erythematosus Research
- Parasite Biology and Host Interactions
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2024
National Institutes of Health
2024
Southwestern Medical Center
2021
The University of Texas Southwestern Medical Center
2021
The Krebs cycle enzyme aconitate decarboxylase 1 (ACOD1) mediates itaconate synthesis in monocytes and macrophages. Previously, we reported that administration of 4-octyl to lupus-prone mice abrogated immune dysregulation clinical features. In this study, explore the role endogenous ACOD1/itaconate pathway development TLR7-induced lupus (imiquimod [IMQ] model). We found that, vitro, ACOD1 was induced mouse bone marrow-derived macrophages human monocyte-derived following TLR7 stimulation....
Schistosomes infect over 200 million of the world’s poorest people, but unfortunately treatment relies on a single drug. Nuclear hormone receptors are ligand-activated transcription factors that regulate diverse processes in metazoans, yet few have been functionally characterized schistosomes. During systematic analysis nuclear receptor function, we found an FTZ-F1-like was essential for parasite survival. Using combination transcriptional profiling and chromatin immunoprecipitation (ChIP),...
The Krebs cycle enzyme Aconitate Decarboxylase 1 (ACOD1) mediates itaconate synthesis in myeloid cells.. Previously, we reported that administration of 4-octyl abrogated lupus phenotype mice. Here, explore the role endogenous ACOD1/itaconate pathway development murine as well their relevance premature cardiovascular damage SLE.
Abstract Mitochondrial synthesis of itaconate by myeloid cells (monocytes and macrophages) is mediated the TCA cycle enzyme Aconitate Decarboxylase 1 (Acod1). Upregulation Acod1–itaconate pathway, occurs after activation various Toll-like receptors (TLRs) or cytokine stimulation (TNF type I Interferons). While anti-inflammatory effects Acod1 – Itaconate pathway have been previously reported (e.g. decreases in IL-6 IL-1β synthesis) contribution impairments endogenous systemic lupus...