A5060486577- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Folate and B Vitamins Research
- Acute Myeloid Leukemia Research
- HER2/EGFR in Cancer Research
- Eosinophilic Disorders and Syndromes
- Prenatal Screening and Diagnostics
- Spinal Fractures and Fixation Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Childhood Cancer Survivors' Quality of Life
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive Biology and Fertility
- Urologic and reproductive health conditions
- Spine and Intervertebral Disc Pathology
- Maternal and fetal healthcare
- Dermatology and Skin Diseases
- Cervical and Thoracic Myelopathy
- Lung Cancer Treatments and Mutations
- Pregnancy and preeclampsia studies
- Synthesis of Tetrazole Derivatives
- Cardiovascular Issues in Pregnancy
University of Sfax
2013-2025
Hopital Universitaire Habib Bourguiba
2025
Hopital Universitaire Hedi Chaker
2018-2024
Hawler Medical University
2023
Ain Shams University
2023
Montefiore Medical Center
2023
National Water Research Center
2023
Rajiv Gandhi Cancer Institute and Research Centre
2023
Medical Genetics Center
2019
Hôpital Farhat Hached
2010
Background. Methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy, but it associated with serious toxicities in considerable number patients.Objectives. The aim the current study was to determine which variables were MTX toxicity children, adolescents and young adults ALL.Material Methods. In this prospective study, 35 patients newly diagnosed ALL, treated according 58951 European Organization for Research Treatment Cancer – Children’s Leukemia Group (EORTC-CLG)...
Knee Osteoarthritis is a considerable public health concern, both in terms of life quality and treatment financial impacts. To investigate this disease, animal models are deemed promising alternative. In fact, although perfect model generally farfetched, the creation that simulate human disease as accurately possible remains an important research stake. This study aims to highlight usefulness induced by injected Mono-Iodo-Acetate standardize it for rabbit species. was infra-patellar...
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms, mainly the C677T, have been implicated as risk factors for several cancers acute lymphoblastic leukemia (ALL). In addition, a potential effect of such variant on efficacy methotrexate (MTX) has reported.In this study, we evaluated impact C677T MTHFR MTX-related toxicity in ALL patients from Tunisia; to provide new insights personalized therapy based human genotype.Genotyping was carried out with restriction fragment length...
Methotrexate (MTX) is a key drug in acute lymphoblastic leukemia (ALL) treatment; it inhibits DNA replication by blocking the conversion of 5, 10 Methylenetetrahydrofolate to 5-methylene tetrahydrofolate methylenetetrahydrofolate reductase (MTHFR). Variants (MTHFR) and MTX related toxicities were largely investigated several populations, nevertheless, results are conflicting.This study aimed assess prevalence MTHFR SNVs: C677>T A1298>C Tunisian patients with ALL relation frequency...
Variant forms of the classic translocation t(8;21) are uncommon and account approximately 3% all t(8;21)(q22;q22) in acute myeloid leukemia (AML) patients. These involve chromosomes 8, 21, other chromosomes. Here we report a Tunisian patient with complex rearrangement t(21;8;1)(q22;q22;q32) revealed by conventional chromosomal study at diagnosis. Fluorescence situ hybridization presence AML1-ETO chimeric gene on derivative chromosome 8. To best our knowledge, this is second case t(21;8;1)...
Background Methylenetetrahydrofolate reductase ( MTHFR ; NM _005957.4) is the key enzyme for folate metabolism which plays in DNA biosynthesis and epigenetic process of methylation. gene polymorphisms, c. 677C>T 1298A>C have been implicated as risk factors several types cancers acute leukemia. Aim We optimized a duplex polymerase chain reaction‐restriction fragment length polymorphism assay PCR ‐ RFLP ) simultaneous detection both variants leukemia patients, from Tunisia. Methods...
Background: Inherited thrombophilia, mainly the Factor V Leiden (FVL) and Prothrombin mutation (PTM) are most risk factors for venous thrombosis especially during pregnancy was strongly associated with recurrent loss (RPL), a devastating reproductive problem that affects more than 1% of couples who trying to conceive. The frequencies also correlation among these polymorphisms RPL have been reported controversially in various populations.Objectives: In this study we evaluated presence...
Acute lymphoblastic leukemia (ALL), a common blood cancer, is characterized by the interaction between genetic and environmental factors. Several variants of Methylenetetrahydrofolate reductase (MTHFR), mainly C677T (rs1801133), may affect susceptibility to ALL.The authors conducted this case-control study evaluate relationship variant MTHFR gene risk ALL.Forty-one patients with ALL 35 non-ALL controls recruited in were genotyped utilizing polymerase chain reaction-restriction fragment...
Abstract Objective Our study aimed to investigate the association between cytochrome P450 1A1 ( CYP1A1 ) polymorphisms (T3801C and A2455G) acute lymphoblastic leukemia (ALL) risk, considering genetic models ethnicity. Materials methods PubMed, Embase, Web of Knowledge, Scopus, Cochrane electronic databases were searched using combinations keywords related risk ALL. Studies retrieved from database searches underwent screening based on strict inclusion exclusion criteria. Results In total,...