A5069251872- Microbial Natural Products and Biosynthesis
- Microbial Metabolism and Applications
- Fungal Biology and Applications
- Plant biochemistry and biosynthesis
- 3D Printing in Biomedical Research
- Plant tissue culture and regeneration
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Plant Surface Properties and Treatments
- Enzyme Production and Characterization
- Agriculture, Soil, Plant Science
- Spectroscopy and Chemometric Analyses
- Pharmacological Effects of Natural Compounds
- Photosynthetic Processes and Mechanisms
- Horticultural and Viticultural Research
- Sesame and Sesamin Research
- Chemical synthesis and alkaloids
- Neuroscience and Neural Engineering
- Phytoestrogen effects and research
- Metalloenzymes and iron-sulfur proteins
- Porphyrin Metabolism and Disorders
- Microbial Fuel Cells and Bioremediation
- Medicinal Plants and Neuroprotection
- Leaf Properties and Growth Measurement
- Phytochemistry and Bioactivity Studies
Korea University
2022-2025
Mokpo National University
2009-2021
Inje University Haeundae Paik Hospital
2015
Seoul National University
1994-2006
Kyung Hee University
2006
Coordination of oxidoreductive modifications in controlling ring cyclization pattern azaphilone biosynthesis.
Cyclization of farnesyl diphosphate into amorpha-4,11-diene by synthase (ADS) initiates biosynthesis artemisinin, a clinically important antimalarial drug precursor. Three possible ring-closure mechanisms, two involving bisabolyl carbocation intermediate followed either 1,3-hydride shift or successive 1,2-shifts, and one germacrenyl carbocation, were proposed tested analyzing the fate H-1 hydrogen atoms through 1H 2H NMR spectroscopy. Migration deuterium atom [1,1-2H2]farnesyl to H-10...
Abstract Sesame (Sesamum indicum L.) is one of the most important oilseed crops, having seeds and its edible oil that are highly valued as a traditional food. Many studies have examined health value sesame oil. Among bioactive components in seeds, lignans tocopherols been identified major antioxidants responsible for resistant oxidative deterioration These same reported to protective effects against human disease such neurodegenerative disease. This review summarizes chemical properties...
Neural organoids display three-dimensional (3D) structures that resemble in vivo neural architectures. Previously, we developed a novel two-dimensional (2D) induction-based protocol for culturing spinal cord organoids, enabling size control and recapitulating tube morphogenesis. In this study, evaluated the application of concept to induce anterior regions brain generate human (hANOs). By inducing neuroepithelial (NE) cells 2D re-aggregating them led tube-forming morphogenesis similar...
Anticoagulation is mandatory for extracorporeal membrane oxygenation (ECMO), but systemic heparinization, which has been most widely used as an anticoagulant, associated with bleeding complications. The present study reviewed the usefulness and safety of nafamostat mesilate a regional anticoagulant in patients complication during ECMO.We retrospectively record 13 cases. dose was regulated to maintain activated clotting time (ACT) or partial thromboplastin (aPTT) values within adequate range...
Taehwan Kwak, Si-Hyung Park, Siyoung Lee, Yujeong Shin, Ki-Jun Yoon, Seung-Woo Cho, Jong-Chan Seung-Ho Yang, Heeyeong Heh-In Im, Sun-Ju Ahn, Woong Sun, Ji Hun Yang. IJSC -0001;0:. https://doi.org/10.15283/ijsc24056
The precise manipulation of the neural stem cell (NSC)-derived differentiation is still challenging, and there a technological barrier to regulate axonal regeneration in controlled manner. Here, we developed microfluidic chip integrated with microelectrode array as an guidance platform. electrode consisted two compartments bridge microchannel that could isolate guide axons. We demonstrated NSCs were largely differentiated into cells electric field was applied chip. also confirmed synergistic...
Monascus species are filamentous ascomycetes fungi and produce azaphilone (Az) pigment that is a well-known food colorant. Az class of fungal polyketides bears highly oxygenated pyranoquinone bicyclic core produced by nonreducing polyketide synthase with reductive release domain (NR-fPKS-R). MpPKS5 encodes an NR-fPKS-R for (MAz) clustered four oxidoreductase genes including mppG; mpp designates production. MAz pigments classified as yellow orange MAz, their structures differ in two hydride...
In vertebrates, the entire central nervous system is derived from neural tube, which formed through a conserved early developmental morphogenetic process called neurulation. Although perturbations in neurulation caused by genetic or environmental factors lead to tube defects (NTDs), most common congenital malformation and precise molecular pathological cascades mediating NTDs are not well understood. Recently, we have developed human spinal cord organoids (hSCOs) that recapitulate some...
Valproic acid (VPA), widely used as an antiepileptic drug, exhibits developmental neurotoxicity when exposure occurs during early or late pregnancy, resulting in various conditions ranging from neural tube defects to autism spectrum disorders. However, toxicity the very stages of development has not been addressed. Therefore, we investigated effects VPA a model where human pluripotent stem cells differentiate into anterior posterior tissues. Exposure induction induced different toxic...
The Monascus azaphilone (MAz) pigment is a well-known food colorant that has yellow, orange and red components. structures of the yellow MAz differ by two hydride reductions, with being reduced form. Orange can be non-enzymatically converted to in presence amine derivatives. It was previously demonstrated mppE mppG are involved biosynthesis MAz, respectively. However, ΔmppE ΔmppG knockout mutants maintained residual production In this study, we deleted region encompassing mppD, M. purpureus...
Abstract The cerebral organoid (CO) model has been used in the study of various neurodegenerative diseases owing to its physiological implications. However, CO may only be representative certain clinical findings affected patients, while some features are not recapitulated. In this study, we found that neurons from patients with Alzheimer’s disease were less responsive depolarization, contrast previous reports. This difference partly attributed variations brain spatial identity depending on...
The biotransformation of (-)-(4R)-isopiperitenone (1) by suspension cell culture Mentha piperita yielded three new hydroxylated derivatives, 4-6, and two epoxidized 7 8. (-)-7-Hydroxyisopiperitenone (2) its glucoside were previously isolated from the culture. structures 4-8 elucidated using spectral methods, their absolute stereochemistry was established NMR experiments correlation with compounds known configuration.