A5042067457- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Child Development and Digital Technology
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Impact of Technology on Adolescents
- EEG and Brain-Computer Interfaces
- Virology and Viral Diseases
- Child and Adolescent Psychosocial and Emotional Development
- Technology Adoption and User Behaviour
- Gender and Technology in Education
- Cognitive Abilities and Testing
- Cognitive Functions and Memory
- Heart Rate Variability and Autonomic Control
- Children's Physical and Motor Development
- Mental Health Research Topics
- Face Recognition and Perception
- Multisensory perception and integration
- Neonatal and fetal brain pathology
- Evolutionary Psychology and Human Behavior
- Early Childhood Education and Development
- Phytochemistry and Bioactive Compounds
- Olfactory and Sensory Function Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- RNA and protein synthesis mechanisms
Cornell University
2023
Birkbeck, University of London
2016-2022
King's College London
2006-2020
South London and Maudsley NHS Foundation Trust
2019
Bethlem Royal Hospital
2019
University of London
2017
City of Hope
2014
Beckman Research Institute
2014
City Of Hope National Medical Center
2014
Yale University
2010
Functional magnetic resonance imaging of brain responses to biological motion in children with autism spectrum disorder (ASD), unaffected siblings (US) ASD, and typically developing (TD) has revealed three types neural signatures: (i) state activity, related the having ASD that characterizes nature disruption circuitry; (ii) trait reflecting shared areas dysfunction US thereby providing a promising neuroendophenotype facilitate efforts bridge genomic complexity heterogeneity; (iii)...
Background There has been increasing interest in the potential for pre‐emptive interventions prodrome of autism, but little investigation as to their effect. Methods A two‐site, two‐arm assessor‐blinded randomised controlled trial ( RCT ) a 12‐session parent‐mediated social communication intervention delivered between 9 and 14 months age (Intervention British Autism Study Infant Siblings‐Video Interaction Promoting Positive Parenting), against no intervention. Fifty‐four infants (28...
Abstract Traditional screen time (e.g. TV and videogaming) has been linked to sleep problems poorer developmental outcomes in children. With the advent of portable touchscreen devices, this association may be extending down age disrupt infants toddlers, an when is essential for cognitive development. However, not demonstrated empirically. This study aims examine whether frequency use associated with toddlers between 6 36 months age. An online survey was administered 715 parents reporting on...
Touchscreen technologies provide an intuitive and attractive source of sensory/cognitive stimulation for young children. Despite fears that usage may have a negative impact on toddlers' cognitive development, empirical evidence is lacking. The current study presents results from the UK Toddler Attentional Behaviours LEarning with Touchscreens (TABLET) project, examining association between touchscreen use attainment developmental milestones. Data were gathered in online survey 715 parents 6-...
In addition to core symptoms, i.e., social interaction and communication difficulties restricted repetitive behaviors, autism is also characterized by aspects of superior perception [1Mottron L. Dawson M. Soulières I. Hubert B. Burack J. Enhanced perceptual functioning in autism: an update, eight principles autistic perception.J. Autism Dev. Disord. 2006; 36: 27-43Crossref PubMed Scopus (1176) Google Scholar]. One well-replicated finding that performance visual search tasks, which...
Background Attention-deficit hyperactivity disorder (ADHD) persists in around two-thirds of individuals adolescence and early adulthood. Aims To examine the cognitive neurophysiological processes underlying persistence or remission ADHD. Method Follow-up data were obtained from 110 young people with childhood ADHD 169 controls on cognitive, electroencephalogram frequency, event-related potential (ERP) actigraph movement measures after 6 years. Results persisters differed remitters...
Abstract We conducted a replication study of our prior report that increased alpha EEG connectivity at 14-months associates with later autism spectrum disorder (ASD) diagnosis, and dimensional variation in restricted interests/repetitive behaviours. 143 infants high low familial risk for ASD watched dynamic videos spinning toys women singing nursery rhymes while high-density was recorded. Alpha functional (7–8 Hz) calculated using the debiased weighted phase lag index. The final sample clean...
A controversial issue is whether self-report of symptoms and impairment sufficient for diagnosis attention-deficit/hyperactivity disorder (ADHD) in adolescents adults the absence other informants, such as parents. The present study investigated how well reflected by cognitive-neurophysiological actigraph measures, which we have previously shown to discriminate between ADHD persisters, remitters controls using parent-report (Cheung et al., 2015; Brit J Psychiat...
The processes underlying persistence and remission of attention-deficit/hyperactivity disorder (ADHD) are poorly understood. We examined whether cognitive neurophysiological impairments on a performance-monitoring task distinguish between ADHD persisters remitters.On average 6 years after initial assessment, 110 adolescents young adults with childhood (87 persisters, 23 remitters) 169 age-matched control participants were compared cognitive-performance measures event-related potentials...
An enhanced ability to detect visual targets amongst distractors, known as search (VS), has often been documented in Autism Spectrum Disorders (ASD). Yet, it is unclear when this behaviour emerges development and if specific ASD. We followed up infants at high low familial risk for ASD investigate how early VS abilities links later diagnosis, the potential underlying mechanisms of association specificity superior Clinical diagnosis well dimensional measures ASD,...
Abstract We previously provided initial evidence for cognitive and event-related potential markers of persistence/remission attention-deficit/hyperactivity disorder (ADHD) from childhood to adolescence adulthood. Here, using a novel brain-network connectivity approach, we aimed examine whether task-based functional reflects marker ADHD remission or an enduring deficit unrelated outcome. High-density EEG was recorded in follow-up 110 adolescents young adults with (87 persisters, 23 remitters)...
Abstract Childhood screen time is associated with both attentional difficulties (for television viewing) and benefits (in action video gamers), but few studies have investigated today’s pervasive touchscreen devices (e.g. smartphones tablets), which combine salient features, interactive content, accessibility from toddlerhood (a peak period of cognitive development). We tested exogenous endogenous attention, following forty children who were stable high (HU) or low (LU) users to pre-school....
Abstract Background ADHD in childhood is associated with development of negative psychosocial and behavioural outcomes adults. Yet, relatively little known about which adulthood factors are predictive these could be targets for effective interventions. To date follow-up studies have largely used clinical samples from the United States children ascertained at baseline using broad criteria including all subtypes or use DSM III criteria. Aims identify child adult predictors comorbid a UK sample...
Cognitive performance in attention-deficit/hyperactivity disorder (ADHD) is characterised, part, by frequent fluctuations response speed, resulting high reaction time variability (RTV). RTV captures a large proportion of the genetic risk ADHD but, importantly, malleable, improving significantly fast-paced, rewarded task condition. Using temporal precision offered event-related potentials (ERPs), we aimed to examine neurophysiological measures attention allocation (P3 amplitudes) and...
Cognitive theories of attention-deficit/hyperactivity disorder (ADHD) propose that high within-subject fluctuations cognitive performance in ADHD, particularly reaction time (RT) variability (RTV), may reflect arousal dysregulation. However, direct evidence dysregulation and how it account for fluctuating RTs ADHD is limited. We used skin conductance (SC) as a measure peripheral aimed to investigate its phenotypic familial association with RTV large sample control sibling pairs.Adolescents...
Elevated theta or theta/beta ratio is often reported in attention deficit hyperactivity disorder (ADHD), but the consistency across studies and relation to hypoarousal are increasingly questioned. Reports of elevated delta related maturational lag attenuated beta activity less well replicated. Some critical inconsistencies could relate differences recording context. We examined if resting-state EEG power global field synchronization (GFS) differed between recordings made at beginning end a...
Background: Twin studies using both clinical and population‐based samples suggest that the frequent co‐occurrence of attention deficit hyperactivity disorder (ADHD) reading ability/disability (RD) is largely driven by shared genetic influences. While disorders are associated with lower IQ, recent twin data variability between difficulties ADHD inattention symptoms independent from influences contributing to general cognitive ability. The current study aimed extend previous findings were...
Background Twin studies indicate that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) symptoms and reading difficulties (RD) is largely due to shared genetic influences. Both disorders are associated with multiple cognitive impairments, but it remains unclear which impairments share aetiological pathway, underlying symptoms. We address this question using a sample twins aged 7–10 range measures previously ADHD or RD. Methods performed multivariate structural...
Objective Zinc is an essential micronutrient that critical for many physiological processes, including glucose metabolism, regulation of inflammation, and intestinal barrier function. Further, zinc dysregulation associated with increased risk chronic inflammatory diseases such as type II diabetes, obesity, bowel disease. However, whether altered status a symptom or cause disease onset remains unclear. Common symptoms these three include the permeability dyshomeostasis. The specific focus...
Interferon regulatory factor-1 (IRF-1) is a master regulator of IFN-γ induced gene transcription. Previously we have shown that IRF-1 transcriptionally induces CEACAM1 via an ISRE (Interferon-Stimulated Response Element) in its promoter. pre-mRNA undergoes extensive alternative splicing (AS) generating isoforms to produce either short (S) cytoplasmic domain expressed primarily epithelial cells or as ITIM-containing long (L) isoform immune cells. The transcriptional and molecular mechanism...
Objective: Previous studies in children with ADHD identified two partially separable familial factors underlying cognitive dysfunction, but evidence adolescents and adults is lacking. Here, we investigate the etiological structure of cognitive-neurophysiological impairments young adults. Method: Factor analyses multivariate models were run 356 participants from control sibling pairs aged 11 to 27 years on data IQ, digit span forward (DSF) backward (DSB), cognitive-performance event-related...