A5063666525- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Diet, Metabolism, and Disease
- Digestive system and related health
- Renal and related cancers
- Circular RNAs in diseases
- Diet and metabolism studies
- Trace Elements in Health
- Global Education and Multiculturalism
- Lipid metabolism and biosynthesis
- Primary Care and Health Outcomes
- Single-cell and spatial transcriptomics
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Chronic Disease Management Strategies
- Fibroblast Growth Factor Research
- Heavy Metal Exposure and Toxicity
- Endoplasmic Reticulum Stress and Disease
- Technology Use by Older Adults
- Brain Metastases and Treatment
- Educational Robotics and Engineering
Cornell University
2018-2024
Center for Cancer Research
2024
Massachusetts General Hospital
2024
Bristol-Myers Squibb (United States)
2024
New York State College of Veterinary Medicine
2023
Yuan's General Hospital
2012-2022
Kaohsiung Medical University
2021-2022
Ministry of Health and Welfare
2021-2022
China Medical University Hospital
2020
China Medical University
2020
Genetic studies have identified ≥240 loci associated with the risk of type 2 diabetes (T2D), yet most these lie in non-coding regions, masking underlying molecular mechanisms. Recent investigating mRNA expression human pancreatic islets yielded important insights into drivers normal islet function and T2D pathophysiology. However, similar microRNA (miRNA) remain limited. Here, we present data from 63 individuals, largest sequencing-based analysis miRNA to date. We characterized genetic...
Aging is a consequence of complex molecular changes, but whether single microRNA (miRNA) can drive aging remains unclear. A miRNA known to be upregulated during both normal and premature miR-29. We find miR-29 also among the top miRNAs predicted aging-related gene expression changes. show that partial loss extends lifespan Zmpste24-/- mice, an established model progeria, indicating functionally important in this accelerated model. To examine alone sufficient promote phenotypes, we generated...
MicroRNAs (miRNAs) are important posttranscriptional regulators of metabolism and energy homeostasis. Dysregulation certain miRNAs in the liver has been shown to contribute pathogenesis Type 2 diabetes (T2D), part by impairing hepatic insulin sensitivity. By small RNA-sequencing analysis, we identified seven (including miR-29b) that consistently aberrantly expressed across five different rodent models metabolic dysfunction share feature resistance (IR). We also showed miR-29b exhibits...
Abstract Biliary tract cancers (BTCs) are a group of deadly malignancies encompassing intrahepatic and extrahepatic cholangiocarcinoma, gallbladder carcinoma, ampullary carcinoma. Here, we present the integrative analysis 63 BTC cell lines via multi-omics clustering genome- scale CRISPR screens, providing platform to illuminate biology inform therapeutic development. We identify dependencies broadly enriched in compared other as well selective anatomic subtypes. Notably, cholangiocarcinoma...
Objective Zinc is an essential micronutrient that critical for many physiological processes, including glucose metabolism, regulation of inflammation, and intestinal barrier function. Further, zinc dysregulation associated with increased risk chronic inflammatory diseases such as type II diabetes, obesity, bowel disease. However, whether altered status a symptom or cause disease onset remains unclear. Common symptoms these three include the permeability dyshomeostasis. The specific focus...
Dyslipidemia and insulin resistance are significant adverse outcomes of consuming high-sugar diets. Conversely, dietary fish oil (FO) reduces plasma lipids. Diet-induced dyslipidemia in a rhesus model better approximates the pathophysiology human metabolic syndrome (MetS) than rodent models. Here, we investigated relationships between parameters hypertriglyceridemia macaques high-fructose diet (n = 59) determined effects FO supplementation or RNA interference (RNAi) on ApoC3 triglyceride...
The emergent of medical science and technology has risen the minimally invasive surgery. Da Vinci Robotic Surgical Systems (RSS) is trend at present. Compared with past surgical methods, many studies related to RSS tend explore postoperative outcomes quality life or compare advantages disadvantages than other Few understand patients' willing who use RSS. This study mainly explores willingness adopts Technology Acceptance Model (TAM) as theoretical foundation, appended trust concept discuss....
Vertical sleeve gastrectomy (VSG) results in an increase the number of hormone-secreting enteroendocrine cells (EECs) intestinal epithelium; however, mechanism remains unclear. Notably, beneficial effects VSG are lost a mouse model lacking nuclear bile acid receptor farnesoid X (FXR). FXR is transcription factor that has been shown to regulate stem cell (ISC) function cancer models. Therefore, we hypothesized VSG-induced EECs due changes differentiation driven by signaling through FXR. To...
Endurance exercise has been shown to improve metabolic outcomes in obesity and type 2 diabetes; however, the physiological molecular mechanisms for these benefits are not completely understood. Although endurance decrease lipogenesis, promote fatty acid oxidation (FAO), increase mitochondrial biosynthesis adipose tissue, muscle, liver, its effects on intestinal lipid metabolism remain unknown. The absorptive cells of small intestine, enterocytes, mediate highly efficient absorption...
Abstract Arsenic is a pervasive environmental toxin that listed as the top priority for investigation by Agency Toxic Substance and Disease Registry. While chronic exposure to arsenic associated with type 2 diabetes (T2D), underlying mechanisms are largely unknown. We have recently demonstrated treatment of INS-1 832/13 pancreatic beta cells impairs glucose-stimulated insulin secretion (GSIS), T2D hallmark. also shown alters microRNA profile cells. MicroRNAs well-established...
Few studies address quality of care in pay-for-performance (P4P) programs from the perspective patients' perceptions. This study aimed to examine and compare patient assessment diabetes chronic as perceived by diabetic patients enrolled not a P4P program self-reported perspectives. A cross-sectional with case comparison group design. large-scale survey was conducted February November 2013 18 healthcare institutions Taiwan. total 1458 (n = 1037) non-P4P 421) participated this large survey....
MicroRNAs (miRNAs) are known regulators of lipid homeostasis. We recently demonstrated that miR-29 controls the levels circulating cholesterol and triglycerides, but mechanisms remained unknown. In present study, we systemic delivery locked nucleic acid inhibitor (LNA29) through subcutaneous injection effectively suppresses hepatic expression dampens de novo lipogenesis (DNL) in liver chow-fed mice. Next, used mice with liver-specific deletion Sirtuin 1 (L-Sirt1 KO), a validated target...
The establishment of the small intestinal (SI) lineage during human embryogenesis ensures functional integrity intestine after birth. chromatin dynamics that drive SI formation and regional patterning in humans are essentially unknown. To fill this knowledge void, we apply a cutting-edge genomic technology to state-of-the-art model early development. Specifically, leverage run-on sequencing (ChRO-seq) define landscape active promoters, enhancers gene bodies across distinct stages directed...
In this study, first, microRNA atlas (and searchable web server) across all major small intestinal epithelial cell types is presented. We have demonstrated microRNAs that uniquely mark several lineages, including enteroendocrine and tuft. Identification of a key marker mouse secretory progenitor cells, miR-672, which we show deleted in humans. used vivo models to establish miR-152 as specific Paneth are highly understudied terms microRNAs.
Metal transporter SLC39A14/ZIP14 is downregulated in pancreatic islets of patients with T2D and mouse models HFD- or db/db-induced obesity. However, the function ZIP14-mediated intracellular zinc trafficking β cells unknown. Our analyses revealed that SLC39A14 only Zn expressed abundantly human besides SLC30A8. Within cells, ZIP14 localized on endoplasmic reticulum serves as a negative regulator insulin secretion, providing potential therapeutic target for T2D.
Background In Asia and some other regions of the world, incense burning is an important folk cultural activity. However, this ritual can cause health impacts, such as chronic respiratory diseases neoplasms. Herein, we describe a family with lead poisoning possibly related to frequent use sticks at home.Case report A 65-year-old homemaker severe anemia, pitting edema lower legs, bone pain, abdominal exertional dyspnea for several months presented our clinic. Her blood workup indicated anemia...
The problem of the aging population and its likely impact on provision healthcare systems has been increasing. This study presents a conceptual model to explore investigate remote patient management (RPM) technology business in enhancing chronic disease care performance. Some scales measure RPM were developed validated, then they used collect survey data from respondents who had experience. In addition, this verified entrepreneurial alertness as moderator influenced relationship between...
MicroRNAs (miRNAs) are important post-transcriptional gene regulators controlling cellular lineage specification and differentiation during embryonic development, including the gastrointestinal system. However, miRNA-mediated regulatory mechanisms involved in early development of human small intestine (SI) remains underexplored. To explore candidate roles for miRNAs prenatal SI humans, we used a multi-omic analysis strategy directed model that programs pluripotent stem cells toward lineage.
Abstract Aging is a consequence of complex molecular changes, but the roles individual microRNAs (miRNAs) in aging remain unclear. One few miRNAs that are upregulated during both normal and premature miR-29. We confirmed this finding our study mouse monkey models. Follow-up analysis transcriptomic changes revealed miR-29 among top predicted to drive aging-related gene expression changes. also showed partial loss extends lifespan Zmpste24 -/- mice, an established model progeria, which...
Abstract The molecular underpinnings of non-alcoholic steatohepatitis (NASH) development in patients are poorly understood. Active enhancer landscapes known to determine cell states and behaviors. Super-enhancers, particular, have helped reveal key disease drivers several cancer types; however, they remain unexplored human NASH. To define the signature NASH-prone (NP) NASH-resistant (NR) phenotypes humans with obesity, we performed chromatin run-on sequencing (ChRO-seq) analysis on liver...
Summary The role of individual miRNAs in small intestinal (SI) epithelial homeostasis is under-explored. In this study, we discovered that miR-375 among the most enriched crypts and stem cells (ISCs), especially facultative ISCs. We then showed by multiple manipulations, including CRISPR/Cas9 editing, strongly suppressed Wnt-signaling. Single-cell RNA-seq analysis SI crypt-enriched from knockout (375-KO) mice revealed elevated numbers tuft increased expression pro-proliferative genes...
Abstract CheckMate 548 (NCT02667587, CM548) is a phase III, randomized trial evaluating first line nivolumab (NIVO) in combination with standard of care (SOC) [surgical resection followed by radiotherapy and temozolomide (TMZ)] versus placebo plus SOC patients newly diagnosed glioblastoma (GBM) positive for promoter methylation O6-methylguanine DNA methyltransferase (MGMT). MGMT status PD-L1 expression predict better outcomes GBM treated TMZ NIVO other indications, respectively. However, the...