A5029011666- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Urinary Tract Infections Management
- MicroRNA in disease regulation
- Pelvic floor disorders treatments
- Ureteral procedures and complications
- Cancer-related molecular mechanisms research
- Social Media in Health Education
- Extracellular vesicles in disease
- Kidney Stones and Urolithiasis Treatments
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Anorectal Disease Treatments and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Hormonal and reproductive studies
- Atrial Fibrillation Management and Outcomes
- Sexual function and dysfunction studies
- Testicular diseases and treatments
- Ovarian cancer diagnosis and treatment
Witten/Herdecke University
2016-2025
Helios Universitätsklinikum Wuppertal
2015-2024
Weatherford College
2024
Helios Hospital Schwerin
2023
Augusta-Kranken-Anstalt
2017
The first global lipidomic profiles associated with urothelial cancer of the bladder (UCB) and its clinical stages progression were identified.
Abstract Smoking is a major risk factor for the development of bladder cancer; however, functional consequences carcinogens in tobacco smoke and cancer–associated metabolic alterations remain poorly defined. We assessed profiles cancer smokers non-smokers identified key their metabolism. LC/MS bioinformatic analysis were performed to determine metabolome associated with further validated cell line models. Smokers found have elevated levels methylated metabolites, polycyclic aromatic...
Background The objective of this study was to evaluate the diagnostic accuracy Bladder EpiCheck test in follow‐up patients with non–muscle‐invasive bladder cancer (NMIBC) and compare it urinary cytology, cystoscopy, and/or histology. Methods In total, 243 were enrolled current study. Patients evaluated by voided urine test, white‐light cystoscopy. Results Overall sensitivity 33.3% for 62.3% EpiCheck, 66.7% 2 tests combined. cytology increased from 7.7% low‐grade (LG) tumors 66.6% high‐grade...
Background: The relationship between case volume and clinical outcomes is well established for most urological procedures but remains underexplored in prostate ultrasound/MRI fusion biopsy (UMFB). UMFB aims to detect clinically significant cancer (csPCa) by adhering detection benchmarks PI-RADS lesions identified via multiparametric MRI (mpMRI). These benchmarks, defined Ahmed et al., include cumulative rate (C-CDR) targets of >80% 5, >50% 4, <20% 1–3. Methods: This retrospective,...
Urologic tumors comprise about 20% of cancer diagnoses in Germany. To date, there are no studies with large datasets on the palliative situation patients urological home environment, although dignified end-of-life care environment is wish most patients. Data from 5125 who received specialized outpatient (SAPV) an underlying between 2017 and 2021 were included analysis. The analysis showed that 91.5% died at symptom burden remained stable or decreased slightly during treatment. median...
Background The objective of the current study was to compare diagnostic accuracy 2 new real‐time polymerase chain reaction–based urinary markers with each other and cytology, cystoscopy, and/or histology in patients being followed for non–muscle‐invasive bladder cancer. Methods A total 487 were enrolled study. Patients evaluated using voided urine Xpert Bladder Cancer Monitor, EpiCheck test, white light cystoscopy. Results overall sensitivity 27.17% 64.13% 66.3% Monitor. specificity 98.82%...
Due to the usage of various measurement methods and definitions, comparing continence rates after radical prostatectomy is a challenging task. This study compares based on different aims identify definition for which agrees best with patients' subjective assessment continence. Additionally, was controlled multiple influencing factors. prospective multicentre carried out in seven hospitals throughout Germany. Before at 3, 6, 12 months surgery self-reporting questionnaires were completed...
Introduction: Prostate cancer (PCa) is the second most frequently diagnosed and fifth cancer-related cause of death worldwide. Various tools are used in diagnosis PCa, such as Prostate-Specific Antigen (PSA) value or digital rectal examination. A final differentiation from benign prostate diseases prostatic hyperplasia (BPH) can often only be made by a transrectal biopsy. This procedure carries post-procedural complications for patients may lead to hospitalization. Urinary exosomes contain...
Radiotherapy and cyclophosphamide-induced haemorrhagic cystitis are rare but severe complications occurring in 3–6% of patients. Hyperbaric oxygen treatment (HBOT) has been demonstrated to be an effective for haematuria not responding conventional management. Only very few data exist long-term follow-up after HBOT. We retrospectively reviewed 15 patients referred HBOT (HC). was performed 130 min/day at a pressure 2.4 atmospheres. evaluated patient demographics, type radio- chemotherapy...
Reliable factors predicting the disease course of non-muscle-invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) are unavailable. Molecular subtypes have potential for prognostic stratification muscle-invasive cancer, while their value CIS patients is unknown. Here, impact both clinico-pathological parameters, including focality, and immunohistochemistry-based surrogate was analyzed a cohort high-risk NMIBC CIS. In 128 CIS, luminal (KRT20, GATA3, ERBB2) basal (KRT5/6, KRT14) markers...
Background: Common diagnostic tools for prostate cancer—prostate-specific antigen and transrectal biopsy—show only low predictive value poor sensitivity. This study examines circulating miRNA in saliva to explore the possibility of a non-invasive easy-to-execute tool cancer screenings. Methods: 16 miRNAs were extracted from salivary exosomes analyzed via delta-CT method. The presented method enables an application test any health institution even outpatient sector. Recruited participants...
High-grade non-muscle-invasive bladder cancer (HG NMIBC) patients are at high risk (HR) of progression to muscle-invasion. Bladder-preserving therapies for this patient subgroup limited, and additional treatments desirable. Recently, enfortumab vedotin, targeting cancer-associated NECTIN4, has been approved the treatment advanced urothelial carcinoma. However, data on expression NECTIN4 its therapeutic potential HR NMIBC scarce. Here, was immunohistochemically analyzed in HG by studying...
We investigated the diagnostic accuracy of renal mass biopsy in an ex vivo model, as well compared agreement preoperative radiological diagnosis with final pathologic diagnosis. Two 18-gauge needle-core and 2 vacuum-needle biopsies were performed from tumors 100 consecutive patients undergoing radical nephrectomy between 2006 2010. The median tumor size was 5.5 cm. There no significant difference regard to cylinder length or tissue quality sampling methods. At least 1 4 needle cores...
Aims: Xpert ® Bladder Cancer Monitor is a urinary marker based on the evaluation of five target mRNAs overexpressed in patients with bladder cancer (BC). The aim our study to update results regarding diagnostic accuracy test follow-up non-muscle invasive (NMIBC). Methods: We conducted prospective 1015 samples 416 (mean age 72.2 ± 10.3 years) under for NMIBC. Patients underwent voided cytology, and cystoscopy and, if positive, transurethral resection bladder. was reported as negative or...
Lymph node metastases are common in pelvic urological tumors, and the age-related remodeling process of lymph nodes influences metastatic behavior. The aim this work is to characterize degenerative changes with respect their occurrence extent. A total 5173 390 patients aged 44 79 years (median 68 years, IQR 62–71 years) were histologically examined for structural changes. size, lipomatous atrophy, capsular fibrosis, framework calcifications recorded semi-quantitatively evaluated by age...
We performed a professional campaign in Germany intending to establish the urologic profession as competent and helpful point of contact for patients with cryptorchidism. The aim this study was assess feasibility quantify efficacy using Internet vs. social media.The strategic design comprised strategy meeting, creation landing page, targeted advertisements on Google form Adwords Facebook sidebar ads sponsored posts. Outcome measurements were number impressions, homepage sessions, downloads...