A5066255017- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Diet, Metabolism, and Disease
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Nicotinic Acetylcholine Receptors Study
- Galectins and Cancer Biology
- Neural dynamics and brain function
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurogenesis and neuroplasticity mechanisms
- Metabolism and Genetic Disorders
- Neuroethics, Human Enhancement, Biomedical Innovations
- Genetics, Aging, and Longevity in Model Organisms
- Cholinesterase and Neurodegenerative Diseases
- Protein Tyrosine Phosphatases
- Cardiovascular Disease and Adiposity
- Health, Environment, Cognitive Aging
University of South Carolina
2019-2025
University of Florida
2015-2024
St. Joseph Hospital
2023
Columbia VA Health Care System
2023
Allen Institute for Brain Science
2017
Florida College
2016
Wake Forest University
2009-2014
University of Maryland, Baltimore
2012
Society for Neuroscience
2011
William & Mary
2006
Working memory functions supported by the prefrontal cortex decline in normal aging. Disruption of corticolimbic GABAergic inhibitory circuits can impair working young subjects; however, relatively little is known regarding how aging impacts cortical signaling and whether such changes contribute to cognitive deficits. The current study used a rat model evaluate effects on expression synaptic proteins relation decline, test pharmacological manipulations improve abilities aged subjects....
Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, hippocampus (HPC) and prefrontal cortex (PFC) show distinct patterns dysfunction advanced age. Because higher functions require large-scale interactions cortical hippocampal networks, selectively targeting an alteration within one region may broadly...
Working memory, the ability to temporarily maintain representational knowledge, is a foundational cognitive process that can become compromised in aging and neuropsychiatric disease. NMDA receptor (NMDAR) activation prefrontal cortex (PFC) necessary for pyramidal neuron activity believed enable working memory; however, distinct biophysical properties localization of NMDARs containing NR2A NR2B subunits suggest unique roles NMDAR subtypes PFC neural memory. Experiments herein show memory...
Abstract Glutamate signaling is essential for the persistent neural activity in prefrontal cortex (PFC) that enables working memory. Metabotropic glutamate receptors (mGluRs) are a diverse class of proteins modulate excitatory neurotransmission via both presynaptic regulation extracellular levels and postsynaptic modulation ion channels on dendritic spines. This receptor significant therapeutic interest treatment cognitive disorders associated with dysregulation. Working memory impairment...
On the 50th anniversary of Society for Neuroscience, we reflect on remarkable progress that field has made in understanding nervous system, and look forward to contributions next 50 years. We predict a substantial acceleration our system will drive development new therapeutic strategies treat diseases over course five decades. also see neuroscience at nexus many societal topics beyond medicine, including education, consumerism, justice system. In combination, advances by basic,...
Radiation therapy has proven efficacy for treating brain tumors and metastases. Higher doses larger treatment fields increase the probability of eliminating neoplasms preventing reoccurrence, but dose field are limited by damage to normal tissues. Normal tissue injury is greatest during development in populations proliferating cells also occurs adults older individuals non-proliferative cell populations. To better understand radiation-induced how it may be affected aging, we exposed young...
Nutritional ketosis is induced by high fat/low carbohydrate dietary regimens, which produce levels of circulating ketone bodies, shifting metabolism away from glucose utilization. While ketogenic diets (KD) were initially introduced to suppress seizures, they are garnering attention for their potential treat a myriad neurodegenerative and metabolic disorders that associated with advanced age. The feasibility physiological impact implementing long-term KD in old animals, however, has not been...
The glucocorticoid (GC) hypothesis posits that effects of stress and dysregulated hypothalamic-pituitary-adrenal axis activity accumulate over the lifespan contribute to impairment neural function cognition in advanced aging. validity GC is bolstered by a wealth studies investigate aging hippocampus decline associated mnemonic functions. prefrontal cortex (PFC) mediates working memory which also decreases with age. While PFC susceptible GCs, few have formally assessed application memory....
Age-related cognitive decline varies widely among individuals, with some showing resilience despite older age. This study examines synaptic markers of glutamatergic and GABAergic neurotransmission in the hippocampus cortex rats differing abilities, aiming to uncover mechanisms that contribute resilience. We observed significant age-related reductions vesicular glutamate transporter VGluT1, particularly stratum oriens (SO), radiatum (SR), lacunosum-moleculare (SLM) dorsal CA3 SLM CA1....
Abstract Increasing evidence shows that cardiovascular diseases (CVDs) are associated with an increased risk of cognitive impairment and Alzheimer’s (AD). It is unknown whether systemic vascular dysfunction occurs prior to the development AD, if this in a sex-dependent manner, endothelial cells play role deposition amyloid beta (Aβ) peptides. We hypothesized onset pathology, thus escalating its progression. Furthermore, from female mice will present exacerbated formation Aβ peptides due...
Defective brain glucose utilization is a hallmark of Alzheimer's disease (AD) while Type II diabetes and elevated blood escalate the risk for AD in later life. Isolating contributions normal aging from coincident metabolic or diseases could lead to refined approaches manage specific health risks optimize treatments targeted susceptible older individuals. We evaluated metabolic, neuroendocrine, neurobiological differences between young adult (6 months) aged (24 male rats. Compared adults, was...
As the number of individuals living beyond age 65 is rapidly increasing, so need to develop strategies combat age-related cognitive decline that may threaten independent living. Although link between altered neuronal signaling and impairments not completely understood, it evident declining abilities are at least partially due synaptic dysfunction. Aging accompanied by well-documented changes in both excitatory inhibitory across species. Age-related alterations uniform brain, however, with...