A5022988545- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Pluripotent Stem Cells Research
- Estrogen and related hormone effects
- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Urological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diet and metabolism studies
- Virus-based gene therapy research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Congenital gastrointestinal and neural anomalies
- Zebrafish Biomedical Research Applications
- Neurological Disease Mechanisms and Treatments
Allen Institute for Brain Science
2019
University of Florida
2009-2018
California Institute for Regenerative Medicine
2011-2012
Stanford University
2005-2012
Florida College
2012
Institute on Aging
2012
University of British Columbia
2000-2005
Queen's University
2000-2002
MILLIONS of neonates undergo anesthesia for surgical or diagnostic procedures each year.1,2Anesthesia kills neonatal brain cells several animal species, including primates,3–6and causes long-term neurocognitive dysfunction.3,5,6Consequently, anesthesia-induced apoptotic cell death is a growing concern within the community, public, and regulatory authorities alike.7However, causal link between dysfunction lacking. If such relationship existed, degree should predict severity dysfunction. We...
Abstract In the dentate gyrus of adult female meadow voles, a high dose estradiol benzoate (EB) increases (within 4 h) then decreases 48) number dividing progenitor cells (Ormerod BK, Galea LAM. 2001. Reproductive status regulates cell proliferation within vole: A possible regulatory role for estradiol. Neurosci 2:169–179). We investigated whether time‐dependent EB exposure differentially influences new granule produced in rat and EB‐stimulated adrenal activity mediates decrease...
Although the brains of lower vertebrates are known to exhibit somewhat limited regeneration after incisional or stab wounds, Urodele brain exhibits extensive massive tissue removal. Discovering whether and how neural progenitor cells that reside in ventricular zones Urodeles proliferate mediate repair response injury may produce novel leads for regenerative strategies. Here we show endogenous resident zone spontaneously proliferate, producing progeny migrate throughout telencephalon before...
The faithful positioning and growth of cells during embryonic development is essential. In this study Seifertet al. demonstrate that inactivation Sonic Hedgehogduring the genital tubercle results in a prolonged G1 phase slower rate growth. During development, are instructed which position to occupy, they interpret these cues as differentiation programmes, expand patterns by hedgehog (Shh) specifies positional identity many organs; however, its role not well understood. study, we show Shh...
We trained and tested young (6–8 months; n = 13), middle-aged (12–14 41), aged (22–24 24) male Fischer 344 rats in a rapid acquisition water maze task then quantified 27 stress hormones, cytokines chemokines their serum, hippocampi frontal cortices using bead assay kits xMAP technology. Middle-aged learned the location of hidden platform over training trials more slowly than counterparts. After training, outperformed on both immediate 24 h retention probe about half (aging) exhibited...
Background The role of histocompatibility and immune recognition in stem cell transplant therapy has been controversial, with many reports arguing that undifferentiated cells are protected from due to the absence major complex (MHC) markers. This argument is even more persuasive transplantation into central nervous system (CNS) where graft rejection response minimal. Methodology/Principal Findings In this study, we evaluate survival neuron production perfectly matched vs. strongly mismatched...
Hippocampal-dependent episodic memory and stimulus discrimination abilities are both compromised in the elderly. The reduced capacity to discriminate between similar stimuli likely contributes multiple aspects of age-related cognitive impairment; however, association these behaviors within individuals has never been examined an animal model. In present study, young aged F344×BN F1 hybrid rats were cross-characterized on Morris water maze test spatial a dentate gyrus-dependent...