A5112782496- Research on Leishmaniasis Studies
- Cytokine Signaling Pathways and Interactions
- Mycobacterium research and diagnosis
- Trypanosoma species research and implications
- Chemical synthesis and pharmacological studies
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Tuberculosis Research and Epidemiology
GlaxoSmithKline (United Kingdom)
2011-2023
University of Maryland, College Park
2020
Franklin & Marshall College
2020
University of Missouri
2020
University of Delaware
2020
Albany State University
2020
University at Albany, State University of New York
2020
Hofstra University
2020
Vanderbilt University
2020
Institute of Medical Sciences
2011
This randomized, open-label study of patients in India with visceral leishmaniasis (VL) investigated the effect food on sitamaquine and desethyl-sitamaquine pharmacokinetics. Patients were randomized to receive oral sitamaquine, 2 mg/kg/day, once a day for 21 days across four cohorts (n = 41) (fasted/fed, fed/fasted, fed/fed, fasted/fasted) over two periods (days 1−10 11−21), or intravenous amphotericin B (AmB), 1 mg/kg every other 30 20). Mean pharmacokinetics area under curve (AUC) (0−τ)...