A5031948238- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
Universidad Autónoma de Baja California
2022
Dyslipidemia is described as a hallmark of metabolic syndrome, promoting stage inflammation (metainflammation) that could lead to misbalances in energetic metabolism, contributing insulin resistance, and modifying intracellular cholesterol pathways the renin-angiotensin system (RAS) pancreatic islets. Low-density lipoprotein (LDL) hypercholesterolemia disrupt tissue communication between Langerhans β-cells hepatocytes, wherein extracellular vesicles (EVs) are secreted by β-cells, exposition...
Cells employ several adaptive mechanisms under conditions of accelerated cell division, such as the unfolded protein response (UPR). The UPR is composed a tripartite signaling system that involves ATF6, PERK, and IRE1, which maintain homeostasis (proteostasis). However, deregulation translation initiation could be associated with breast cancer (BC) chemoresistance. Specifically, eukaryotic factor-4A (eIF4A) involved in unfolding secondary structures mRNAs at 5′ untranslated region (5′-UTR),...