A5052626822- Effects of Environmental Stressors on Livestock
- Reproductive Physiology in Livestock
- Endoplasmic Reticulum Stress and Disease
- Synthesis and biological activity
- Genetic and phenotypic traits in livestock
- Systemic Lupus Erythematosus Research
- Nutritional Studies and Diet
- Diabetes and associated disorders
- Pregnancy and preeclampsia studies
- Fungal Plant Pathogen Control
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Systemic Sclerosis and Related Diseases
- Ubiquitin and proteasome pathways
- Liver Diseases and Immunity
- Plant Physiology and Cultivation Studies
- Exercise and Physiological Responses
- Genomics, phytochemicals, and oxidative stress
- Metastasis and carcinoma case studies
- Cancer and Skin Lesions
- Microbial Metabolites in Food Biotechnology
- Synthesis and Characterization of Heterocyclic Compounds
- Pancreatic function and diabetes
- Heat shock proteins research
- Quinazolinone synthesis and applications
Universidad Autónoma de Baja California
2015-2024
The employment of privileged scaffolds in medicinal chemistry supplies scientists with a solid start the search for new and improved therapeutic molecules. One these is imidazole ring, from which several derivatives have shown wide array biological activities. A series 2,4,5-triphenyl were synthesized, characterized, evaluated vitro as antioxidant molecules using 1,1-diphenyl-2-picrylhydrazyl (DPPH.) 2-2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS.+) assays, acetylcholinesterase...
Dyslipidemia is described as a hallmark of metabolic syndrome, promoting stage inflammation (metainflammation) that could lead to misbalances in energetic metabolism, contributing insulin resistance, and modifying intracellular cholesterol pathways the renin-angiotensin system (RAS) pancreatic islets. Low-density lipoprotein (LDL) hypercholesterolemia disrupt tissue communication between Langerhans β-cells hepatocytes, wherein extracellular vesicles (EVs) are secreted by β-cells, exposition...
Cells employ several adaptive mechanisms under conditions of accelerated cell division, such as the unfolded protein response (UPR). The UPR is composed a tripartite signaling system that involves ATF6, PERK, and IRE1, which maintain homeostasis (proteostasis). However, deregulation translation initiation could be associated with breast cancer (BC) chemoresistance. Specifically, eukaryotic factor-4A (eIF4A) involved in unfolding secondary structures mRNAs at 5′ untranslated region (5′-UTR),...
Dyslipidemias involving high concentrations of low-density lipoproteins (LDLs) increase the risk developing triple-negative breast cancer (TNBC), wherein cholesterol metabolism and protein translation initiation mechanisms have been linked with chemoresistance. Doxorubicin (Dox) treatment, a member anthracycline family, represents typical therapeutic strategy; however, chemoresistance remains significant challenge. Exosomes (Exs) secreted by tumoral cells implicated in cell communication...
Approximately 80% of breast cancer (BC) cases are estrogen receptor positive (ER+) and sensitive to hormone treatment; Tamoxifen is a prodrug, its main plasmatic active metabolites 4-hydroxytamoxifen (4-OH Tam) endoxifen. Despite the effectiveness tamoxifen therapy, resistance can be developed. An increment in eukaryotic initiation factor-4A complex (eIF4A) activity result tamoxifen-resistant tumor cells. For this work, we developed cell variant resistant 4-OH Tam endoxifen, denominated...
The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids which are characteristic feature of Diabetes Mellitus type 2 (DM2). However, some species do not fibril structures. By employing biomimetic approach we generated an extensive panel optimized sequences IAPP drastically reduce aggregation propensity. A structural and cellular characterization analysis was performed on the C-terminal domain with highest...
IntroductionIsthmin 2 (ISM2) is a protein which expression in humans almost specific to the placenta. There no previous report literature that investigated this preeclampsia or choriocarcinoma.MethodsWe conducted prospective, cross-sectional study included women with preeclampsia, gestational hypertension and normotensive pregnancy. We measured serum concentrations of ISM2 performed immunohistochemistry placenta tissues. also samples from choriocarcinoma compare lung, prostate, colon,...
Twenty-two multiparous Pelibuey ewes managed under intensive conditions were exposed to rams and used for blood sample collection during one year, evaluate the effect of season year on estrous cycle characteristics, ovulation corpus luteum functionality arid in Mexico (32° NL).Rams daily introduced with identify behavior, while samples individually collected twice per week determine through progesterone concentrations.Additionally, every three days an overall functionality.Estrous cycles...
Salivary immunoglobulin A (sIgA) kinetics in young adults with an average or excellent aerobic capacity before and after a cardiopulmonary graded exercise test Background: Aim: To compare the concentration of secretory immunoglobulin-A test.Methods: Participants were nine apparently healthy physically active males (Mean age = 21.3 ± 2.1 yr.), randomly allocated two groups based on their VO 2 max: a) (AEC, n 5) b) (EAC, 4).Participants performed Bruce protocol to determine capacity.The sIgA...
Human islet amyloid polypeptide (hIAPP) corresponds to a 37-residue hormone present in insulin granules that maintains high propensity form β-sheet structures during co-secretion with insulin. Previously, employing biomimetic approach, we proposed panel of optimized IAPP sequences only one residue substitution shows the capability reduce amyloidogenesis. Taking into account specific membrane lipids have been considered as key factor induction cytotoxicity, this study, following same design...
Potential Inhibitors of The OTUB1 Catalytic Site to Develop an Anti-Cancer Drug Using In-Silico Approaches
Cancer is a serious health problem due to the complexity of establishing an effective treatment. The purpose this work was evaluate activity triazaspirane as migration and invasion inhibitor in PC3 prostatic tumor cells through possible negative regulation FAK/Src signal transduction pathway decreased secretion metalloproteinases 2 9. Molecular docking analysis performed using Moe 2008.10 software. Migration (wound-healing assay) (Boyden chamber assays were performed. In addition, Western...
Cervicouterine cancer (CC) is a health problem worldwide and the fourth most common in women, with greater proportion of individuals affected by advanced stages disease developing countries.To determine sensitivity specificity TruScreen™ opto-electronic device vs. conventional cytology CC screenings.This prospective observational study that included who presented for first time at Dysplasia Clinic Instituto Nacional de Cancerología from March 1 through April 30, 2016, those referred due to...
To investigate the effects of progesterone supplementation at two different times on serum (P4) concentration, conception rate and resynchronization cooled Holstein heifers in summer, 90 were randomly assigned to groups: (i) subjected TAI (timed artificial insemination) from days 4 14 after (S1; n = 45); (ii) under same protocol as S1 17 22 (S2; 45). The groups S2 10 before 21 TAI. Respiratory rate, body surface temperature, vaginal temperature rectal recorded during experiment not (P >...