A5005543104- Genomics and Phylogenetic Studies
- Glycosylation and Glycoproteins Research
- Biofuel production and bioconversion
- Cardiovascular Disease and Adiposity
- Abdominal Surgery and Complications
- Obesity, Physical Activity, Diet
- Polyamine Metabolism and Applications
- Attention Deficit Hyperactivity Disorder
- RNA and protein synthesis mechanisms
- Colorectal Cancer Surgical Treatments
- COVID-19 and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- PI3K/AKT/mTOR signaling in cancer
- Sleep and related disorders
- Mindfulness and Compassion Interventions
- Cardiac, Anesthesia and Surgical Outcomes
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Impact on Reproduction
- Carbohydrate Chemistry and Synthesis
- Body Composition Measurement Techniques
McMaster University
2021-2025
Impact
2025
University of Waterloo
2021-2023
Hospital for Sick Children
2020-2023
University of Toronto
2021-2022
York University
2021-2022
Windsor University School of Medicine
2022
Great Ormond Street Hospital
2022
University College London
2022
SickKids Foundation
2022
Abstract Phosphorylation of intrinsically disordered eIF4E binding proteins (4E-BPs) regulates cap-dependent translation by weakening their ability to compete with eIF4G for within the initiation complex. We previously showed that phosphorylation T37 and T46 in 4E-BP2 induces folding a four-stranded beta-fold domain, partially sequestering canonical eIF4E-binding helix. The C-terminal region (C-IDR), remaining after phosphorylation, contains secondary site three other phospho-sites, whose...
O-GlcNAc transferase (OGT) is an essential glycosylating enzyme that catalyzes the addition of N-acetylglucosamine to serine or threonine residues nuclear and cytoplasmic proteins. The glycosylates a broad range peptide sequences prediction glycosylation sites has proven challenging. lack experimentally verified set polypeptide are not glycosylated by OGT made legitimate more difficult. Here, we tested number intrinsically disordered protein regions as substrates establish OGT. negative data...
Yoga has been shown to play a role in reducing the symptoms associated with inattentive and hyperactive-impulsive forms of attention-deficit/hyperactivity disorder (ADHD). The medical history clinical findings for nine-year-old patient presenting difficulty paying attention impulsive speech actions at home school are presented. After diagnosis combination type ADHD by assessment DSM-5 criteria, both through parent teacher evaluations using National Institute Children’s Health Quality (NICHQ)...
The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the mental health and wellbeing of Ontario's youth. Our study investigated psychological impacts COVID-19 pediatric population Ontario, using survey derived from Revised Children's Anxiety Depression Scale (RCADS) system to identify children who may benefit seeking professional help. cross-sectional examined potential risk factors that contributed worsening in children, including changes sleep patterns,...
Abstract O-GlcNAc transferase (OGT) is an essential glycosylating enzyme that catalyzes the addition of N-acetylglucosamine to serine or threonine residues nuclear and cytoplasmic proteins. The glycosylates a broad range peptide sequences prediction glycosylation sites has proven challenging. lack experimentally verified set polypeptide are not glycosylated by OGT made legitimate more difficult. Here, we tested number intrinsically disordered protein regions as substrates establish OGT....
Anastomotic leaks (ALs) are serious postoperative complications. Current experimental studies designed to investigate based on acute intraoperative dehiscence of the anastomosis. Clinically, however, AL usually happens later in course. Presented here is a clinically relevant colonic model swine.Seventeen Yorkshire pigs were divided into 2 groups: control group (n = 6) and 11). An enterotomy was performed descending colon an end-to-end handsewn anastomosis created groups. The proximal distal...