A5019405093- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Biomedical Research and Pathophysiology
- Cancer Cells and Metastasis
- Neuroscience and Neural Engineering
University of Groningen
2022
Utrecht University
2022
Abstract Despite the increasing incidence of kidney-related diseases, we are still far from understanding underlying mechanisms these diseases and their progression. This lack is partly because a poor replication in vitro, limited to planar culture. Advancing towards three-dimensional models, hereby propose coaxial printing obtain microfibers containing helical hollow microchannel. These recapitulate architecture proximal tubule (PT), an important nephron segment often affected kidney...
Airway cholinergic nerves play a key role in airway physiology and disease. In asthma other diseases of the respiratory tract, neurons undergo plasticity contribute to hyperresponsiveness mucus secretion. We currently lack human vitro models for neurons. Here, we aimed develop model peripheral using pluripotent stem cell (hPSC) technology. hPSCs were differentiated towards vagal neural crest precursors subsequently directed functional neurotrophin brain-derived neurotrophic factor (BDNF)....