A5014883889- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- RNA Research and Splicing
- RNA modifications and cancer
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- RNA Interference and Gene Delivery
- Influenza Virus Research Studies
- COVID-19 Impact on Reproduction
- Airway Management and Intubation Techniques
- Chemical Synthesis and Analysis
- CAR-T cell therapy research
- interferon and immune responses
- Infant Nutrition and Health
- Mobile Health and mHealth Applications
- Immune Response and Inflammation
- Family and Patient Care in Intensive Care Units
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Click Chemistry and Applications
Lurie Children's Hospital
2020-2025
Northwestern University
2020-2023
Midwestern University
2023
Pediatrics and Genetics
2021
University of Wisconsin–Madison
2010-2011
Regulatory complexes formed on mRNAs control translation, stability, and localization. These possess two activities: one that binds RNA another—the effector—that elicits a biological function. The Pumilio FBF (PUF) protein family of binding proteins provides versatile scaffold to design select with new specificities. Here, the PUF is used target translational activation repression specific mRNAs, induce poly(A) addition removal. To do so, we linked activator, GLD2, or repressor, CAF1....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 180 million people since the onset of pandemic. Despite similar viral load and infectivity rates between children adults, rarely develop severe illness. Differences in host response to virus at primary infection site are among mechanisms proposed account for this disparity. Our objective was investigate SARS-CoV-2 nasal mucosa adults compare it with syncytial (RSV) influenza virus. We analyzed clinical...
Abstract Rationale Despite similar viral load and infectivity rates between children adults infected with SARS-CoV-2, rarely develop severe illness. Differences in the host response to virus at primary infection site are among proposed mechanisms. Objectives To investigate respiratory syncytial (RSV), influenza (IV) nasal mucosa adults. Methods Clinical outcomes gene expression were analyzed 36 hospitalized SARS-CoV-2 infection, 24 RSV 9 IV 16 mild moderate 7 healthy pediatric 13 adult...
Background Respiratory syncytial virus (RSV) can cause life-threatening respiratory failure in infants. We sought to characterize the local host response RSV infection nasal mucosa of infants with critical bronchiolitis and identify early admission gene signatures associated clinical outcomes. Methods Nasal scrape biopsies were obtained from 33 admitted pediatric intensive care unit (PICU) requiring non-invasive support (NIS) or invasive mechanical ventilation (IMV), RNA sequencing (RNA-seq)...
Background/Aims Procedures performed in the paediatric intensive care unit require optimal efficiency. This study evaluated feasibility of a mobile app for critical trainees to help improve efficiency three common procedures: central line placement, arterial insertion and chest tube insertion. Methods Data regarding frequency forgotten items were collected during pre-intervention stage. A was developed with checklist users gather all correct equipment. number from period following initial...