A5075901741- Recycling and Waste Management Techniques
- Alzheimer's disease research and treatments
- Microplastics and Plastic Pollution
- biodegradable polymer synthesis and properties
- Electrochemical Analysis and Applications
- Force Microscopy Techniques and Applications
- Nanoparticles: synthesis and applications
- Carbon and Quantum Dots Applications
- Enzyme-mediated dye degradation
- Quantum Dots Synthesis And Properties
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Microbial Metabolism and Applications
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Lipid Membrane Structure and Behavior
- Municipal Solid Waste Management
- Graphene and Nanomaterials Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Extraction and Separation Processes
- Analytical Chemistry and Sensors
- Protein Structure and Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Biotin and Related Studies
- Composting and Vermicomposting Techniques
BOKU University
2014-2025
Bundesamt für Wasserwirtschaft
2019-2024
Forschungszentrum Jülich
2015-2023
Stadtwerke Jülich (Germany)
2015-2016
University of Vienna
2008-2014
Microplastics (MPs) present in terrestrial environments show potential leaching risk to deeper soil layers and aquifer systems, which threaten health drinking water supply. However, little is known about the environmental fate of MPs natural sediments. To examine transport mechanisms sediments, column experiments were conducted using different sediments (10-150 µm) with conservative tracer. Particle breakthrough curves (BTCs) retention profiles (RPs) numerically interpreted HYDRUS-1D three...
The quantity and type of macro- microplastics was investigated in rotting material during the composting process two state-of-the-art plants Austria. Microplastics >0.2 mm, were found already after first turning event both facilities. generation more extensive plant that used shorter intervals four weeks generated approx. 21 particles per week kg-1 DM. After 4 operation less microplastic detected, which suggested fractionated to smaller sizes processing. In addition, a total nine composts...
Amyloid-β oligomers (AβO) have become representative biomarkers for early diagnosis of Alzheimer's disease. Here, we report on an aptasensor based stem-loop probes sensitive and specific detection AβO by amperometric transducer principle using alternating current voltammetry (ACV). Stem-loop with redox-active moieties are immobilized a gold substrate as receptor element. The signal transduction mechanism relies redox ferrocene (Fc) reporting via charge transfer molecular recognition event...
Epithelial ovarian cancer involves the shedding of single tumor cells or spheroids from primary into ascites, followed by their survival, and transit to sites metastatic colonization within peritoneal cavity. During flotation, anchorage-dependent epithelial-type gain anoikis resistance, implicating integrins, including αvß3. In this study, we explored escape, cisplatin prosurvival signaling as a function αvß3 transmembrane conformational activation state in suspended ascites. A high-affinity...
The elimination of amyloid beta (Aβ) oligomers is a promising strategy for therapeutic drug development Alzheimer's disease (AD). AD mouse models that develop Aβ pathology have been used to demonstrate in vivo efficacy compounds later failed clinical development. Here, we analyze the concentration and size distribution different transgenic human brain samples by surface-based fluorescence intensity analysis (sFIDA), highly sensitive method detecting quantitating protein aggregates. We dose-...
Plastics are a ubiquitous material with good mechanical, chemical and thermal properties, used in all industrial sectors. Large quantities, widespread use, insufficient management of plastic wastes lead to low recycling rates. The key challenge waste is achieving higher degree homogeneity between the different polymer streams. Modern sorting plants use automated sensor-based systems capable sort out commodity plastics, while many engineering such as polyoxymethylene (POM), will end up mixed...
Amyloid-β (Aβ) oligomers represent a promising biomarker for the early diagnosis of Alzheimer's disease (AD). However, state-of-the-art methods immunodetection Aβ in body fluids show large variability and lack reliable stable standard that enables reproducible quantitat ion oligomers. At present, only available applied these assays is based on random aggregation process synthetic has neither defined size nor known number epitopes. In this report, we generated highly range native exposes The...
Oligomers of the amyloid-β (Aβ) protein are suspected to be responsible for development and progression Alzheimer's disease. Thus, compounds that able eliminate already formed toxic Aβ oligomers is very desirable. Here, we describe in vivo efficacy compound RD2, which was developed directly specifically oligomers. In a truly therapeutic, rather than preventive study, oral treatment with RD2 reverse cognitive deficits significantly reduce pathology old-aged transgenic Disease mice full-blown...
Organic aromatic compounds used for dyeing and coloring in the textile industry are persistent hazardous pollutants that must be treated before they discharged into rivers surface waters. Therefore, we investigated potential of white rot fungus Phanerochaete velutina to decolorize commonly reactive dyes. The decolorized average 55% Reactive Orange 16 (RO-16) after 14 days at a maximum rate 0.09 d−1 half-life 8 days. Furthermore, determined inhibitory effects co-present inorganic contaminants...
The microsomal stability assay is commonly used to rank compounds according their metabolic stability. Determination of the unbound intrinsic clearance (CL<sub>in,u</sub>) essential for accurate comparison compounds, since nonspecific binding microsomes can lead an underestimation clearance. In this study, a new method (linear extrapolation in assay, LESA) was established, which allows direct calculation CL<sub>in,u</sub> from data, without need independently determine fraction free...
Despite the development of biorefinery processes, so far this area does not take into account possibility coupling “conventional” composting process with production biochemicals. However, net carbon monoxide (CO) has been observed during bio-waste composting. So far, O2 concentration and temperature have identified as main variables influencing CO formation. This study aimed to investigate under controlled laboratory conditions, depending on different aeration rates temperatures. A series...
The large intensities available with femtosecond (fs) laser pulses allow permanent structural modifications in transparent materials high spatial resolution. Irradiation of self-standing biopolymer films, such as collagen, pure and curcumin doped gelatine employing a 60-fs high-power 11 MHz Ti-Sapphire oscillator system linked to an optical microscope led ablation. Swelling consisting the foaming irradiated area formation single layer bubbles arranged around narrow ablation crater were...
Abstract Early diagnostics at the preclinical stage of Alzheimer’s disease is utmost importance for drug development in clinical trials and prognostic guidance. Since soluble Aβ oligomers are considered to play a crucial role pathogenesis, several methods aim quantify body fluids such as cerebrospinal fluid (CSF) blood plasma. The highly specific sensitive method surface-based fluorescence intensity distribution analysis (sFIDA) has successfully been established oligomer quantitation CSF...
Abstract Reactive organic dyes are hazardous pollutants that should be removed from wastewater the textile industry. A remediation of dye polluted can achieved by using oxidative properties nanomaterials, such as ZnO nanoparticles, or microorganisms and their degrading enzymes. Promising approaches expected hybrid strategies, which use more than one approach. However, nanoparticles also reported to an antimicrobial antifungal agent, may undermine decolorization ability potent organisms,...