A5052904126- Mast cells and histamine
- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- melanin and skin pigmentation
- Polyamine Metabolism and Applications
- T-cell and B-cell Immunology
- Food Allergy and Anaphylaxis Research
- Plant Virus Research Studies
- Eosinophilic Disorders and Syndromes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Click Chemistry and Applications
- Poxvirus research and outbreaks
- Single-cell and spatial transcriptomics
- Veterinary Oncology Research
- Garlic and Onion Studies
- Bacteriophages and microbial interactions
- Coconut Research and Applications
Karolinska University Hospital
2015-2022
Karolinska Institutet
2015-2022
Utrecht University
2014
Mast cell accumulation is a hallmark of number diseases, including allergic asthma and systemic mastocytosis. Immunoglobulin E-mediated crosslinking the FcεRI receptors causes mast activation contributes to disease pathogenesis. The lineage one least studied among hematopoietic lineages, controversies remain about whether expression appears during progenitor stage or terminal maturation. Here, we used single-cell transcriptomics analysis reveal temporal association between appearance gene...
CD8(+) CTLs detect virus-infected cells through recognition of virus-derived peptides presented at the cell surface by MHC class I molecules. The cowpox virus protein CPXV012 deprives endoplasmic reticulum (ER) lumen for loading onto newly synthesized molecules inhibiting transporter associated with Ag processing (TAP). This evasion strategy allows to avoid detection immune system. In this article, we show that CPXV012, a 9-kDa type II transmembrane protein, prevents peptide transport ATP...
BackgroundSystemic mastocytosis (SM) is a haematological disease characterised by organ infiltration neoplastic mast cells. Almost all SM patients have mutation in the gene encoding tyrosine kinase receptor KIT causing D816V substitution and autoactivation of receptor. Mast cells CD34+ haematopoietic progenitors can carry mutation; however, which progenitor cell subset arises unknown. We aimed to investigate distribution single stem cells.MethodsFluorescence-activated single-cell index...
// Katarina Lyberg 1, 3 , Hani Abdulkadir Ali 2, Jennine Grootens Matilda Kjellander 2 Malin Tirfing 1 Michel Arock 4 Hans Hägglund 5 Gunnar Nilsson 3, * Johanna Ungerstedt Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet clinical immunology transfusion medicine, University Hospital, Stockholm, Sweden Huddinge, Hematology Center, Mastocytosis Center Karolinska, Hospital Institutet, Molecular Cellular Oncology, LBPA CNRS UMR 8113, Ecole Normale...
Background: Systemic mastocytosis (SM) is a hematological disease characterized by organ infiltration neoplastic mast cells. Almost all SM patients have mutation in the gene encoding tyrosine kinase receptor KIT causing D816V substitution and autoactivation of receptor. Mast cells CD34 + hematopoietic progenitors can carry mutation, however, which progenitor cell subset arises unknown. We aimed to investigate distribution single stem Methods: Fluorescence-activated single-cell index sorting...
Abstract Mast cell accumulation is a hallmark of number diseases including allergic asthma and systemic mastocytosis. IgE-mediated crosslinking the FcεRI receptors causes mast activation contributes to disease pathogenesis. The lineage one least studied among hematopoietic lineages there are still controversies about identity progenitor, i.e., whether expression appears during progenitor stage or in maturing cells. Here, we used single-cell transcriptomics reveal temporal association between...