A5075511961- Dental materials and restorations
- Oral microbiology and periodontitis research
- Dental Erosion and Treatment
- Bone Tissue Engineering Materials
- Advanced Sensor and Energy Harvesting Materials
- Nanoplatforms for cancer theranostics
- Conducting polymers and applications
- Dental Anxiety and Anesthesia Techniques
- Bone and Dental Protein Studies
- Dental Implant Techniques and Outcomes
- Dental Trauma and Treatments
- Laser Applications in Dentistry and Medicine
- Extracellular vesicles in disease
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Electrospun Nanofibers in Biomedical Applications
- Dental Research and COVID-19
- Salivary Gland Disorders and Functions
- Endodontics and Root Canal Treatments
- Organic Electronics and Photovoltaics
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Luminescence and Fluorescent Materials
Xi'an Jiaotong University
2016-2025
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2024
Tianjin University
2020-2024
BOE Technology Group (China)
2024
Stomatology Hospital
2014-2024
Nanjing Drum Tower Hospital
2024
Frontier Science Foundation
2021
East China Normal University
2021
Institute of Science and Technology
2021
Wuhan University
2011-2014
Abstract Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self‐healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from catechol groups effect epigallocatechin‐3‐gallate (EGCG, green tea derivative), a smart hydrogel be conveniently obtained through copolymerization complex formed by EGCG 3‐acrylamido phenylboronic acid...
ABSTRACT There is still an urgent need to develop hydrogels with intelligent antibacterial ability achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy hydrogel dressing bacteria-responsive self-activating property multiple nanozyme activities remodel microenvironment in order significantly promote healing. Specifically, pH-responsive H2O2 self-supplying composite (MSCO) pH/enzyme-sensitive triblock...
Understanding the key factors influencing mechanical and electrical properties of semiconducting polymers is crucial to development stretchable electronics. In this work, a high-mobility diketopyrrolopyrrole-based conjugated polymer with varied number-average molecular weights (Mn) was used as model system explore impact weight on properties. Higher-Mn films are more ductile stretchable. Both hole mobilities thin-film transistors elastic modulus become maximum at moderate Mn 88 kg/mol. It...
Biomineralization in vertebrates is a ubiquitous and tightly regulated process which creates hierarchical structures for the skeleton. Because of lack understanding applicability cell‐based or biological systems to achieve intrafibrillar mineralization, scientists adopted various vitro methods elucidate mechanism mineralization. In this article, biomimetic mineralization collagen its wide ramifications reviewed. It intriguing how prevailing mechanisms derived from two potentially discordant...
Abstract Biomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP) precursors. These precursors infiltrate the extracellular collagen matrix where they undergo phase transformation into intrafibrillar carbonated apatite. Although it well established that ACP are released from intracellular vesicles through exocytosis, an unsolved enigma this cell‐mediated mineralization process how precursors, initially produced mitochondria, translocated to vesicles. The present...
The development of novel applications ultralong organic phosphorescent (UOP) materials is highly desired. Herein, a series UOP (EDCz, E = O, S, Se, and Te) for bacterial afterglow imaging photodynamic therapy (PDT) reported. By structurally bonding with the chalcogen atoms π-conjugated scaffolds, EDCz not only absorbs visible light but also emits an efficiency ca. 0.01–6.8% long lifetime 0.08–0.318 s under ambient conditions. Benefiting from long-lived triplet excited states, SeDCz...
Exosome-based therapy is emerging as a promising strategy to promote bone regeneration due exosomal bioactive cargos, among which circular RNA (circRNA) has recently been recognized the key effector. The role of circRNA derived from marrow mesenchymal stem cells (BMSCs) not well-defined. present study aimed clarify regulatory function and molecular mechanism BMSC-derived in osteogenesis. Exosomes (BMSC-Exos) were isolated identified. BMSC-Exos' pro-osteogenic effect on MC3T3-E1 was validated...
The development of a highly effective photosensitizer (PS) that can be activated with low-power single light is pressing issue. Herein, we report PS for synergistic photodynamic and photothermal therapy constructed through self-assembly poly(selenoviologen) on the surface core-shell NaYF4:Yb/Tm@NaYF4 upconversion nanoparticles. hybrid UCNPs/PSeV showed strong ROS generation ability high conversion efficiency (∼52.5%) under mildest reported-to-date irradiation conditions (λ = 980 nm, 150...
To simultaneously obtain outstanding stretchability, strength, and charge mobility of conjugated polymers (CPs) has remained a challenge for the field stretchable electronics to date. Herein, we propose strategy increasing molecular weight near-amorphous CP poly(indacenodithiophene-co-benzothiadiazole) (IDT-BT) an ultrahigh level overcome trade-off. Detailed weight-dependent study confirms that can enhance mechanical transport properties IDT-BT, owing higher extent chain entanglement larger...
To regulate the mechanical properties of poly(indacenodithiophene-alt-benzothiadizole) (IDT-BT), a high-mobility polymer semiconductor with high ductility but inferior elasticity (plastic deformation onset strain (PdOS) < 10%), triisopropylsilyl (TIPS), hydroxyl (OH), and 2-ureido-4[1H]-pyrimidone (UPy) groups were introduced into its side chain ends. The incorporation bulky neutral TIPS led to slightly increased had no obvious influence on polymer. presence OH resulted in enhanced without...
Achieving stretchable semiconductors with high carrier mobility, stretchability, and elastic recovery (ER) simultaneously remains challenging in the field of electronics. Herein, we demonstrate that increasing polarity flexible blocks polyurethane matrices can reduce their miscibility high-mobility conjugated polymer PDPPT3, promoting favorable phase separation blend films for improved fracture strain (εF), ER, mobility. Blends based on a poly(tetramethylene oxide) block-containing matrix...
Abstract Photo‐electronic devices based on reactive oxygen species (ROS) generation suffer a crucial limitation in wound treatment due to their sandwich structure, which prevents the contact of ROS with tissue. In this work, first anti‐sandwich structured visible‐light/electricity dual‐responsive dressing is constructed for methicillin‐resistant Staphylococcus aureus (MRSA), selenoviologen‐appendant polythiophene (SeV 2+ ‐PT)‐containing polyacrylamide hydrogels. The new named an...
Oxidative stress has been suggested as an important pathogenic factor contributing to chronic periodontitis with diabetes mellitus (CPDM). Previous studies have revealed the potential therapeutic properties of baicalein (BCI) in oxidative stress-related diseases; however, antioxidant effects BCI on therapy for individual CPDM remain largely unexplored. Nuclear erythroid 2-related 2 (Nrf2) plays a critical role cellular defence against stress. In this study, we aim determine whether prevents...
Polymer semiconductors with large elastic recovery (ER) under high strain in thin film state are highly desirable for stretchable electronics. Here we report a type of semiconductor PU(DPP)x, by copolymerization oligodiketopyrrolopyrrole-based conjugated block and hydrogenated polybutadiene flexible via urethane linkage intermolecular hydrogen bonding. By regulating ratio, PU(DPP)35 35 wt % exhibits intrinsic ER > 80% 175% (ε) pseudo free-standing state, comparable commercial elastomers,...
Traumatic brain injury (TBI) contributes to the key causative elements of neurological deficits. However, no effective therapeutics have been developed yet. In our previous work, extracellular vesicles (EVs) secreted by stem cells from human exfoliated deciduous teeth (SHED) offered new insights as potential strategies for functional recovery TBI. The current study aims elucidate mechanism action, providing novel therapeutic targets future clinical interventions. With miRNA array performed...
To date, the preparation of high-performance stretchable and elastic semiconductors remains challenging yet urgently demanded by electronics field. Herein, we design a multiblock polyurethane elastomer matrix PBTTT-b-HTPB incorporating crystalline oligothiophene flexible polyolefin blocks to blend with conjugated polymers for high-mobility semiconductor nanofilms enhanced stretchability elasticity. The compatibility between polymer is found play key role in manipulating vertical lateral...