A5054888512- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Titanium Alloys Microstructure and Properties
- Heat shock proteins research
- Mesenchymal stem cell research
- Metal and Thin Film Mechanics
- Electrospun Nanofibers in Biomedical Applications
- Bone and Joint Diseases
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Virus-based gene therapy research
- Bone Metabolism and Diseases
- Laser Applications in Dentistry and Medicine
- thermodynamics and calorimetric analyses
- Herpesvirus Infections and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
- Orthopedic Infections and Treatments
- Cancer therapeutics and mechanisms
- Graphene and Nanomaterials Applications
- Influenza Virus Research Studies
- Bone and Dental Protein Studies
- RNA Interference and Gene Delivery
- Dental materials and restorations
Hospital Universitario La Paz
2016-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2025
Centro de Investigación Biomédica en Red
2015
Universidad Autónoma de Madrid
2002-2012
Instituto de Investigaciones Biomédicas Sols-Morreale
2001-2002
Centro de Investigaciones Biológicas Margarita Salas
1993-2001
Consejo Superior de Investigaciones Científicas
1994-2001
John Radcliffe Hospital
2001
University of Miami
1998
Universidad Complutense de Madrid
1993-1997
Cancer therapy has been characterized throughout history by ups and downs, not only due to the ineffectiveness of treatments side effects, but also hope reality complete remission cure in many cases. Within therapeutic arsenal, alongside surgery case solid tumors, are antitumor drugs radiation that have treatment choice some instances. In recent years, immunotherapy become an important alternative, is now first Nanotechnology recently arrived on scene, offering nanostructures as new...
Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by the inflammatory environment, which changes during tissue repair. Macrophages are essential in mediating response after injury and can adopt a range functional phenotypes, exhibiting pro-inflammatory anti-inflammatory activities. An accurate characterization MSC activation milieu needed for improving efficacy regenerative therapies. In this work, we investigated immunomodulatory functions primed with factors secreted...
Implantation of scaffolds may elicit a host foreign body response triggered by monocyte/macrophage lineage cells. Growing evidence suggests that topographical cues play an important role in MSC functionality. In this work, we examined whether surface features can regulate paracrine interactions MSCs establish with macrophages. Three-dimensional (3D) topography sensing drives into spatial arrangement stimulates the production anti-inflammatory proteins PGE2 and TSG-6. Compared to...
Pulse treatment of U-937 promonocytic cells with cadmium chloride (2 h at 200 μm) provoked apoptosis and induced a rapid phosphorylation p38 mitogen-activated protein kinase (p38<sup>MAPK</sup>) as well late extracellular signal-regulated kinases (ERK1/2). However, although the p38<sup>MAPK</sup>-specific inhibitor SB203580 attenuated apoptosis, process was not affected by ERK-specific PD98059. The attenuation cadmium-provoked highly specific effect. In fact, did prevent generation heat...
Infection of HeLa cells with adenovirus-carrying HSF1+ cDNA, which encodes a mutated form HSF1 constitutive transactivation capacity, increased multidrug resistance 1 (MDR1) mRNA level and P-glycoprotein (P-gp) cell surface content stimulated rhodamine 123 accumulation vinblastine efflux activity. On the other hand, infection HSP70 andHSP27 cDNAs did not increase MDR1/P-gp expression. regulates expression at transcriptional level, since bound heat-shock consensus elements (HSEs) in MDR1 gene...
Abstract Background The mechanisms by which macrophage phenotype contributes to mesenchymal stem cells (MSC)-mediated bone repair remain unclear. In this work, we investigated the influence of factors released human macrophages polarized a pro-inflammatory or an anti-inflammatory on ability MSC attach, migrate, and differentiate toward osteoblastic lineage. We focused role TNF-α IL-10, key cytokines, respectively, in regulating functions. Methods were treated with media conditioned study...
Comparative modeling of the DNA-binding domain human HSF1 facilitated prediction possible binding pockets for small molecules and definition corresponding pharmacophores. In silico screening a large library lead-like compounds identified set that satisfied pharmacophoric criteria, selection which was purchased to populate biased sublibrary. A discriminating cell-based assay compound 001, subjected systematic analysis structure-activity relationships, resulting in development 115 (IHSF115)....
Abstract In this work, we investigated a new approach to incorporate Mg particles within PDLLA matrix using solvent‐free commercially available process. PDLLA/Mg composites were manufactured by injection moulding and the effects of incorporated into on MSC macrophage responses evaluated. Small amounts (≤1 wt %) do not cause thermal degradation PDLLA, which retains its mechanical properties. release hydrogen, alkaline products 2+ ions without changing pH culture media. Mg‐containing materials...