A5072451761- Health and Wellbeing Research
- Healthcare Education and Workforce Issues
- Diverse Approaches in Healthcare and Education Studies
- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Obesity, Physical Activity, Diet
- Korean Urban and Social Studies
- School Health and Nursing Education
- Plant-derived Lignans Synthesis and Bioactivity
- Collaborative and Sustainable Housing Initiatives
- NF-κB Signaling Pathways
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Reforms
- Cell death mechanisms and regulation
- Nutrition, Health and Food Behavior
- Teacher Education and Leadership Studies
- Autophagy in Disease and Therapy
- Education and Learning Interventions
- Redox biology and oxidative stress
- Immune Response and Inflammation
- Healthcare Policy and Management
- S100 Proteins and Annexins
- EFL/ESL Teaching and Learning
- Genomics, phytochemicals, and oxidative stress
- Workplace Health and Well-being
Busan Institute of Science and Technology
2025
Inje University Busan Paik Hospital
2020-2024
Inje University
2016-2024
Korea University
2010-2021
Weatherford College
2021
National Medical Center
2021
Korea Institute of Radiological and Medical Sciences
2015-2020
Kangwon National University
2011-2017
National Health Insurance Service
2013-2014
Catholic University of Korea
2014
We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed PA treatment also induces cell death among two other non-small lung cancer (NSCLC) lines: NCI-H1299 and A549 cells (IC50 values = 7.6 16.1 nM, respectively). Our experiments further showed was able to induce via various mechanisms. First, dose-dependently induced cycle arrest at G2/M phase, as shown by accumulation of the mitosis-related proteins, p21, survivin Aurora B. This phase due...
// Jeong Hyun Cho 1, * , Hyo-Ji Lee Hyun-Jeong Ko 2 Byung-Il Yoon 3 Jongseon Choe 4 Keun-Cheol Kim 1 Tae-Wook Hahn A. Han 5 Sun Shim Choi 6 Young Mee Jung 7 Kee-Ho 8 Yun-Sil 9 Yu-Jin Department of Biological Sciences, Kangwon National University, Chuncheon, Republic Korea College Pharmacy, Veterinary Medicine, Microbiology, School Biochemistry and Molecular Biology, Medical Biotechnology, Biomedical Science, Chemistry, Division Radiation Cancer Research, Institute Radiological Nowon-gu,...
To identify a conceptual link among health-promoting behaviour, interpersonal support and perceived stress to examine whether the between behaviour would be mediated by women with abdominal obesity.Abdominal obesity is strong risk factor for cardiovascular disease in its reduction can achieved weight loss. Adopting may critical successful loss.A cross-sectional, correlational study design.Study participants were 126 obesity, who comprised baseline sample Community-based, Heart Weight...
Here, we report a new intracellular signaling pathway involved in γ-ionizing radiation (IR)-induced migration/invasion and show that podophyllotoxin acetate (PA) inhibits the IR-induced invasion migration of A549 cells (a non-small cell lung cancer (NSCLC) line). Our results revealed IR increased invasion/migration cells, this effect was decreased by 10 nM PA treatment. also inhibited expressions/activities matrix metalloprotase (MMP) -2, MMP-9, vimentin, suggesting could block...
Few studies have examined the differential effects of weight management by exercise mode on subclinical atherosclerosis. We hypothesized that 3 modes aerobic, resistance, and combination exercises flow-mediated dilation (FMD), carotid-femoral pulse wave velocity (PWV), carotid intima-media thickness (IMT) as well cardiometabolic profile in management. A randomized, single-blind trial (ISRCTN46069848) was conducted Seoul, South Korea between November 2011 December 2012. Randomized...
This paper aims to develop and analyze the effects of a socio-ecological model-based intervention program for preventing metabolic syndrome (MetS) among office workers. The was developed using regular health examinations, “health behavior need” assessment survey workers, focus group study. According type intervention, subjects took part in three groups: education via an intranet-based web magazine (Group 1), self-monitoring with U-health system 2), target population who received intensive...
Purpose: The purpose of this study was to identify the factors influencing nursing work performance among clinical nurses in hospital.Methods: This descriptive correlational collected data from 122 who were working three tertiary referral hospitals Busan. collected, using self-reported questionnaires, September 2 October 14, 2019. analyzed statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression SPSS/WIN 25.0 program.Results: Nursing significantly associated with...
We aimed to investigate the factors affecting healthcare utilization among patients with single and multiple chronic diseases using Andersen model.We used a combination of data from sixth seventh Korea National Health Nutrition Survey (2014-2016). The study population was 3,901 disease 1,829 as defined by WHO. Participants were aged 19 yr or older. Multiple regression analysis employed model identify (inpatient outpatient).According (comprising predisposing, enabling, need health behaviors),...
Podophyllotoxin acetate (PA) acts as a radiosensitizer against non-small cell lung cancer (NSCLC) in vitro and vivo. In this study, we examined its potential role chemosensitizer conjunction with the topoisomerase inhibitors etoposide (Eto) camptothecin (Cpt). The effects of combinations PA Eto/Cpt were CompuSyn software two NSCLC lines, A549 NCI-H1299. Combination index (CI) values indicated synergistic inhibitors. intracellular mechanism underlying synergism was further determined using...
To describe uncertainty in surrogate decision-making regarding end-of-life care for people with dementia using Mishel's reconceptualized illness theory.
The purpose of the study is to assess relationship between prevalence metabolic syndrome–related risk factors and work tenure among office workers. A 10-year cohort analysis was conducted using employees’ health examinations given new employees within 1 or 2 years joining firm every 5 thereafter. Age-adjusted odds ratios (95% confidence interval [CI], p < .05) were calculated based on a contrast test with general estimating equations. Specifically, age-adjusted CIs those 20 ± work,...
Previously, we demonstrated that γ-ionizing radiation (IR) triggers the invasion/migration of A549 cells via activation an EGFR–p38/ERK–STAT3/CREB-1–EMT pathway. Here, have involvement a novel intracellular signaling mechanism in (IR)-induced migration/invasion. Expression receptor-interacting protein (RIP) 1 was initially increased upon exposure A549, non-small cell lung cancer (NSCLC) line, to IR. IR-induced RIP1 is located downstream EGFR and involved expression/activity matrix...
Previously, we identified AMRI-59 as a specific pharmaceutical inhibitor of peroxiredoxin (PRX) I enzyme activity. In this study, examined whether acts radiosensitizer in non-small cell lung cancer cells using clonogenic assays. The intracellular mechanisms underlying the radiosensitization effect were determined via immunoblotting addition to measurement ROS generation, mitochondrial potential and death. activity vivo was by co-treating nude mice with compound γ-ionizing radiation (IR),...
This study aimed to develop a job description for healthcare managers of metabolic syndrome management programs using task analysis.Exploratory research was performed by the Developing Curriculum method, Intervention Wheel model, and focus group discussions. Subsequently, we conducted survey 215 workers from 25 community health centers verify that created accurate.We defined role managers. Next, elucidated tasks needs analysis examine frequency, importance, difficulty each their duties....
This study aimed to identify individual and socio-ecological barriers in managing healthy eating among low-income children from the perspective of community childcare (CCC) center workers (n = 18) through focus group interviews. They perceived increase obesity children. The interviews revealed that child's habits are affected by not only determinants including self-regulation risk awareness but also environmental factors such as family, CCC centers, policy social structure. To enhance...
Purpose: The aim of this study was to determine the perceived needs and confidence school nurses in health education at middle high schools Seoul, Korea. Methods: A descriptive survey questionnaire developed by a research team investigate across eight areas. total 329 secondary metropolitan areas Seoul participated. Descriptive statistics, t-test, ANOVA were conducted analyze data. Results: Generally means needs(Mean: 3.8~4.7/5) (Mean 3.3~4.5/5) reported. However, there significantly low...
In this study, we examined whether β-apopicropodophyllin (APP) could act as a radiosensitizer in non-small cell lung cancer (NSCLC) cells.The vitro radiosensitizing activity of APP was demonstrated with clonogenic assay, immunoblotting, Annexin V-Propidium iodide (PI) BrdU incorporation, detection mitochondrial ROS/intracellular H2O2, membrane potential detection, and performing isolation cytosolic fractions. The vivo determined xenografted mice co-treatment IR based on measurement tumor...
Purpose: The purpose of this study was to compare the effectiveness case management in elderly medicaid beneficiaries according geographic location. Methods: Data were collected from 23,633 assigned over users medicaid. We used need assessment tool developed by government, which consists 19 items with four subscales. Results: Among beneficiaries, statistically significant differences observed for quality life, self-care competency, medical care utility, and support system. Differences higher...
To investigate the feasibility, safety, and outcomes of three-dimensional (3D) laparoscopic vaginoplasty with a rectosigmoid colon flap for vaginal reconstruction.Following appropriate preoperative patient counseling, 17 consecutive patients underwent using 3D system. Perioperative postoperative were retrospectively evaluated.Between September 2016 February 2020, flap. Of them, 15 (88%) transgender female patients, 2 (12%) cisgender congenital deformities. Among 12 (80%) de novo surgeries 3...