A5050997960- Nanoplatforms for cancer theranostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
- Advanced Glycation End Products research
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- Biochemical effects in animals
- Pluripotent Stem Cells Research
- Natural Antidiabetic Agents Studies
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Diabetes and associated disorders
- Diabetes Management and Research
- Amino Acid Enzymes and Metabolism
- Receptor Mechanisms and Signaling
- Cancer therapeutics and mechanisms
- Cancer Cells and Metastasis
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
Pohang University of Science and Technology
2020-2024
Human neutrophils are the most abundant leukocytes and have been considered as first line of defence in innate immune system. Selective imaging live will facilitate situ study infection or inflammation events well clinical diagnosis. However, small-molecule-based probes for discrimination among different granulocytes human blood yet to be reported. Herein, we report fluorescent probe NeutropG specific distinction active neutrophils. The selective staining mechanism is elucidated...
Liver cancer is one of the leading causes cancer-related deaths, with a significant increase in incidence worldwide. Novel therapies are needed to address this unmet clinical need. Indocyanine green (ICG) broadly used fluorescence-guided surgery (FGS) agent for liver tumor resection and has potential conversion targeted therapy. Here, we report design, synthesis, investigation series iodinated ICG analogs (I-ICG), which can be develop ICG-based radiopharmaceutical We applied CRISPR-based...
Hepatocellular carcinoma (HCC) is by far the predominant malignant liver cancer, with both high morbidity and mortality. Early diagnosis surgical resections are imperative for improving survival of HCC patients. However, limited clinical methods, it difficult to accurately distinguish tumor tissue its boundaries in early stages cancer. Herein, we report two fluorescent probes, cLG hLR, detection cancer healthy cells, respectively, enabling precise providing complementary imaging. These...
CDy1 is a powerful tool to distingusih embryonic stem cells for reprogramming studies and regeneration medicine. However, the cell selectivity mechanism of has not been fully understood. Here, we report ALDH2 ABCB1 as molecular targets CDy1, elucidated by live-cell affinity-matrix ABC transporter CRISPRa library screening. The two unique orthogonal mechanisms provide potential multi-demensional cellular distinction specific types.
Cell labelling using a small fluorescent probe is an important technique in biomedical sciences. We previously developed biocompatible and membrane-permeable probe, CO-1, which has low nonspecific binding affinity towards nontarget molecules. Although this background-free tame been utilized for of various intracellular biomolecules live cells, the probes' backgroung-free staining mechanism was not fully understood. Here, we propose that Gating-Oriented Live-cell Distinction (GOLD) occurs...
Advanced glycation end products (AGEs) play a significant role in the aging processes, further regarding as hallmark of aging. Despite importance, lack monitoring tools has hampered study relationship between AGEs and Here, we firstly report novel AGEs-selective probe, AGO. AGO presented its ability to detect more sensitively than conventional approach measuring autofluorescence from AGEs. In addition, confirmed that can depending on kinetics, reflecting by preference ribose-derived Finally,...
A novel fluorescent probe, AGO, systematically detects advanced glycation end products involved in aging.
Abstract This review discusses the use of fluorescent probes for identifying, isolating, and monitoring cells organelles. Fluorescent have advantages over antibodies in live‐cell staining due to their small size ability penetrate cellular membrane without fixatives or permeabilizers. However, different cell types exhibit mechanisms based on genetic profiles composition proteins, enzymes, lipids. The authors introduce a gating‐oriented distinction mechanism where transporters such as solute...
Abstract Human neutrophils are the most abundant leukocytes and have been considered as first line of defence in innate immune system. Selective imaging live will facilitate situ study infection or inflammation events well clinical diagnosis. However, small‐molecule‐based probes for discrimination among different granulocytes human blood yet to be reported. Herein, we report fluorescent probe NeutropG specific distinction active neutrophils. The selective staining mechanism is elucidated...