A5080661491- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Bone and Dental Protein Studies
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Radiomics and Machine Learning in Medical Imaging
- Bone health and treatments
- Oral and Maxillofacial Pathology
- Lung Cancer Research Studies
Hospital Sant Joan de Déu Barcelona
2020-2025
Red de Investigación en Actividades Preventivas y Promoción de la Salud
2020-2025
Institut de Recerca Sant Joan de Déu
2020-2023
We aimed to expand and refine the experimental models for pediatric-type diffuse high grade gliomas (pHGG) methods follow up disease progression in mouse pHGG xenografts. Using whole exome sequencing immunoassays we characterized primary cultures xenografts established at hospital SJD Barcelona. obtained tumor samples serial CSF from To assess progression, evaluated: (1) weight, (2) human cell counts brain paraffin sections, (3) DNA amount, quantified through droplet digital polymerase chain...
Diffuse intrinsic pontine glioma (DIPG) is a chemo-resistant, incurable pediatric tumor of the central nervous system (CNS). The blood–brain barrier (BBB) remains intact in course disease, preventing drugs from entering brain and resulting therapeutic failure. topoisomerase I inhibitor SN-38 shows strong anticancer activity patient-derived DIPG cell line vitro, though low CNS bioavailability anti-DIPG efficacy vivo. In this work, we produced SN-38-loaded polymeric nanoparticles an...
Abstract The goals of this work were to identify factors favoring patient‐derived xenograft (PDX) engraftment and study the association between PDX prognosis in pediatric patients with Ewing sarcoma, osteosarcoma, rhabdomyosarcoma. We used immunodeficient mice establish 30 subcutaneous from patient tumor biopsies, a successful rate 44%. Age greater than 12 years relapsed disease associated higher rate. Tumor type biopsy location did not associate engraftment. models retained histology...
Successful engraftment of human cancer biopsies in immunodeficient mice correlates with the poor prognosis patients. This was reported 30 years ago for children neuroblastoma, but standard care treatment evolved significantly during last 15 years, leading to improved survival these Here, we evaluated association patient-derived xenograft (PDX) and patients receiving up-to-date treatments cancers classified as metastatic (stage M) high-risk neuroblastoma (HR-NB) by International Neuroblastoma...
Abstract Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) shows potent preclinical anticancer activity in pediatric solid tumors such as Ewing sarcoma, rhabdomyosarcoma and neuroblastoma, but responses clinical trials have been modest. In this work, we aimed to discover a rational biomarker-based approach select the right candidate patients for treatment. We assessed efficacy of nab-paclitaxel 27 patient-derived xenografts (PDX), including 14 sarcomas, five rhabdomyosarcomas several...