A5056768751- Pediatric Urology and Nephrology Studies
- Neuroblastoma Research and Treatments
- Urological Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Ureteral procedures and complications
- Radiomics and Machine Learning in Medical Imaging
- Latin American Literature Studies
- Cardiac electrophysiology and arrhythmias
- Electrospun Nanofibers in Biomedical Applications
- Cardiac pacing and defibrillation studies
- Glioma Diagnosis and Treatment
- Spanish Literature and Culture Studies
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Nanopore and Nanochannel Transport Studies
- Virus-based gene therapy research
- Kidney Stones and Urolithiasis Treatments
- Cancer Genomics and Diagnostics
- Cardiac Arrhythmias and Treatments
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Genomics and Chromatin Dynamics
- Comparative Literary Analysis and Criticism
Hospital Sant Joan de Déu Barcelona
2013-2025
Red de Investigación en Actividades Preventivas y Promoción de la Salud
2025
Institut de Recerca Sant Joan de Déu
2021
Hospital Universitari Germans Trias i Pujol
2018
Sant Joan de Déu Research Foundation
2015
Universitat de Barcelona
2013-2014
ABSTRACT Ewing sarcoma (ES) is an aggressive bone and soft tissue neoplasm characterized by EWSR1/ETS rearrangements whose cellular origin remains unclear. EWS-FLI1 expression in human pediatric mesenchymal stem cells (hpMSCs) induces a quantitatively qualitatively different transcriptional response than its adult MSCs (haMSCs), but fails to form tumors vivo . ES have early developmental lineage signatures distinct from postnatal MSCs. Here, we generated experimental teratomas out of...
We aimed to expand and refine the experimental models for pediatric-type diffuse high grade gliomas (pHGG) methods follow up disease progression in mouse pHGG xenografts. Using whole exome sequencing immunoassays we characterized primary cultures xenografts established at hospital SJD Barcelona. obtained tumor samples serial CSF from To assess progression, evaluated: (1) weight, (2) human cell counts brain paraffin sections, (3) DNA amount, quantified through droplet digital polymerase chain...
Purpose: The aim of our study is to compare the outcomes open and laparoscopic pyeloplasty in children less than 12 months age. Patients Methods: We reviewed all medical charts patients old who underwent from January 2007 February 2013. divided them two groups: Open (OP) (LP). following data were analyzed: age, sex, weight, US measurements, operative time, hospital stay, complications, success rate. Quantitative analyzed with Student t test or Mann-Whitney U test, chi-square Fisher for...
Abstract The goals of this work were to identify factors favoring patient‐derived xenograft (PDX) engraftment and study the association between PDX prognosis in pediatric patients with Ewing sarcoma, osteosarcoma, rhabdomyosarcoma. We used immunodeficient mice establish 30 subcutaneous from patient tumor biopsies, a successful rate 44%. Age greater than 12 years relapsed disease associated higher rate. Tumor type biopsy location did not associate engraftment. models retained histology...
Abstract Delivery of chemotherapy in the surgical bed has shown preclinical activity to control cancer progression upon subtotal resection pediatric solid tumors, but whether this new treatment is safe for tumor‐adjacent healthy tissues remains unknown. Here, Wistar rats are used study anatomic and functional impact electrospun nanofiber matrices eluting SN‐38—a potent chemotherapeutic agent—on several body sites where tumors such as neuroblastoma, Ewing sarcoma, rhabdomyosarcoma arise....