Reduced graphene oxide nanosheets decorated with ZnS and ZnS-Ag nanoparticles are successfully prepared via a facile one-step chemical approach consisting of reducing the metal precursors on rGO surface. Prepared rGO-ZnS nanocomposite is employed as an adsorbent material against two model dyes: malachite green (MG) ethyl violet (EV). The adsorptive behavior was tuned by monitoring some parameters, such time contact between dye adsorbent, dose. Experimental data were also simulated kinetic...

Microemulsions, comprising oil, water and a surfactant, in association with some co-surfactant, are thermodynamically stable systems. They have found applications large number of chemical pharmacological processes due to their unique properties such as interfacial area, low tension, most importantly, the ability solubilize deliver hydrophobic drugs. In addition oral intravenous route, they suitable for drug delivery through ophthalmic, vaginal, pulmonary, dental, topical routes. This review...

Since their inception, therapeutic or prophylactic vaccines have emerged as promising candidates for the prevention treatment of infections and various diseases, including cancer autoimmune disorders. In recent times, gold nanoparticles (GNPs) acquired active roles in field vaccine development due to intrinsic capacity adjust enhance immune response. Due characteristics, GNPs can exert optimal effects both delivery vehicles adjuvants. Despite significant importance vaccinology, numerous...

Poly( N -isopropylacrylamide/2-acrylamido-2-methylpropane sulfonic acid) microgel was prepared and fabricated with silver nanoparticles to design a material for dual functions of catalyst sensor.

in silico modeling, using Psipred and ExPASy servers was employed to determine the structural elements of Bcr-Abl oncoprotein (p210(BCR-ABL)) isoforms, b2a2 b3a2, expressed Chronic Myelogenous Leukemia (CML). Both these proteins are tyrosine kinases having masses 210-kDa differing only by 25 amino acids coded b3 exonand an acidsubstitution (Glu903Asp). The secondary structure two show differences five α-helices nine β-strands which relates SH3, SH2, SH1 DNA-binding domains. These can result...

The structure of human Methylenetetrahydrofolate Reductase (MTHFR) is not known either by NMR or X-ray methods. Phosphorylation seems to play an important role in the functioning this flavoprotein. MTHFR catalyzes irreversible reaction homocysteine metabolism. decreases activity enhancing sensitivity enzyme SAdenosylmethione. Two common polymorphisms MTHFR, Ala222Val and Glu429Ala, can result a number vascular diseases. Effects Glu429Ala polymorphism on remain undetermined due limited...

Introduction: Infection by intestinal parasites in childhood may be the main cause of many health-related problems developed countries such as anemia, anorexia, loss appetite, retarded growth and development.The aim present study was to assess effect different on white adipose tissue hormones.Material methods: Eighty-one children infected 35 apparently healthy were enrolled this study.All patients controls subjected clinical examination, measurement body mass index (BMI) laboratory...

Because sulfonylureas directly activate the exocytotic machinery, we were interested in extent to which these compounds penetrate β-cell plasma membrane and underlying molecular mechanism(s). We now provide evidence that cross phospholipid bilayer membranes rapidly effectively by a free-diffusion mechanism. Two sulfonylurea investigated 1H nuclear magnetic resonance spectroscopy, glibenclamide tolbutamide, found incorporate into bilayers, with ionizable sulfonamide exposed aqueous interface...

In order to investigate the diversity of ABO and Rh blood group genes in Saudi Arabian population, we assembled phenotypic data approximately 66,000 subjects from ten representative populations: Al-Khobar, Riyadh, Tabuk/Madina Al-Munawaara, Jeddah, Abha, South region, Sakaka, Domah, Al-Qurayat, Sweer.The frequencies p[A], q[B], r[O] alleles at locus were observed be 0.1688, 0.1242, 0.7070, respectively, frequency D allele was 0.7138.The heterozygosities loci 0.4563 0.4086, while combined...

Polymorphisms in interleukin genes are involved the pathogenesis of breast cancer.This study investigated polymorphisms promoter regions IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control employing 80 female subjects who were pathologically diagnosed with cancer.All patients received follow-up care at Mansoura University Hospital, Mansoura, Egypt.We included another females (controls) from same population, showing no signs malignancy.Clinicopathological features examined E.S....

The cure for Alzheimer's disease (AD) is still unknown. According to Cholinergic hypothesis, caused by the reduced synthesis of neurotransmitter, Acetylcholine. Regional cerebral blood flow can be increased in patients with Acetylcholinesterase (AChE) inhibitors. In this regard, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20- Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis porphyrinatoIron(III) nitrosyl (FeNOTPPS) were investigated as candidate...

An understanding of the ABO and Rh blood group systems is important for transfusions also pertinent due to their potential association with certain morbidities susceptibilities infections.To investigate diversity differentiation loci in Middle Eastern populations, data from twelve representative populations were analyzed.Six conformity Hardy-Weinberg equilibrium at locus.The pooled heterozygosity both was calculated be highest sample Jordan lowest Bahrain.Heterogeneity pronounced Northern...

Short birth intervals (SBIs) and long (LBIs) have been shown to serious implications for health of both mothers their children. This study was aimed investigate the determinants reproductive outcome SBI LBI in a multiethnic Pakistani population.In cross-sectional prospective design, 2798 women admitted tertiary-care hospital Islamabad delivery were recruited data on second or higher order deliveries collected. Birth defined as short (<24 months) (>36 months). The terms perinatal...

Structural reorganization of chromosomes by genomic duplications and/or deletions are known as copy number variations (CNVs). Pathogenic and disease susceptible CNVs alter gene dosage its phenotypic expression that often leads to human genetic diseases including Neurological disorders. affecting same common genes in multiple neurodevelopmental disorders can better explain the shared clinical aetiology across brain diseases. Our study presents novel a cohort five multiplex consanguineous...

Infection of mothers with schistosomiasis and filariasis has been shown to influence infant responses neonatal Bacille Calmette-Guérin (BCG) immunization. The genetic makeup infants is also considered an important determinant for the activity BCG vaccine. effect natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphism on efficacy vaccine was examined in neonates helminth-infected (63 infants) results were compared uninfected (187 infants). After vaccination, assessment...

The introduction of nanotechnology-based applications in agriculture is important to tackle the difficulties faced by and food sector across globe. Nanomaterials facilitate controlled delivery nutrients with increased crop protection. Due their direct indirect applications, nanomaterials can support development high-tech agricultural farms. This exactly what needed maximize output improvement ability plants absorb from soil.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an outbreak of a pandemic worldwide. The spike (S) protein SARS-CoV-2, which plays key role in the receptor recognition and cell membrane fusion process, is composed two subunits, S1 S2. subunit contains receptor-binding domain that recognizes binds host angiotensin-converting enzyme (ACE2), while S2 mediates viral with subsequent entry into cells. Mutations are particular...

The use of Porphyrin derivatives as photosensitizers in Photodynamic Therapy (PDT) was investigated by means a molecular docking study. These molecules can bind to intracellular targets such P-type CaCa(2+) ATPase sarcoplasmic reticulum (SERCA1a). CAChe software successfully employed for conducting the Tetraphenylporphinesulfonate(TPPS), 5,10,15,20- Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis nitrosyl (FeNOTPPS) with from rabbit. results show...

The structure of α(2)-µ-Globulin fragment (A2-f) is not known.α(2)-µ-Globulin a 15.5 kDa protein that binds equimolar amount fatty acids in male rat kidneys. expression this has been shown to change response druginduced and genetic hypertension which suggests it plays an important role renal acid metabolism under pathological conditions as well normal conditions. A2-f sequence homology with amino 28-178 (A2U) synthesized pre-dominantly the liver present urine. It believed unusual structural...

Silver and palladium nanoparticles were prepared by in situ chemical reduction using Sodium Borohydride as a reducing agent at 18 ° C. The synthesis of pure hybrid cryogels the incorporation silver inside cryogel network, was confirmed x-ray diffraction analysis energy dispersive respectively. antibacterial activities checked against Staphylococcus aureus (ATCC: 2593) Escherichia coli 25922) bacteria. After taking into account facile synthetic process adsorption performance, these can serve...

Diabetic Nephropathy (DN) poses a major health problem. There is strong evidence for potential role of the eNOS gene. The aim this case control study was to investigate possible genetic variants endothelial Nitric Oxide Synthase (eNOS) gene and oxidative stress in pathogenesis nephropathy patients with diabetes mellitus. included 124 diabetic patients; 68 these had no (group 1) while 56 exhibited symptoms 2). Sixty two healthy non-diabetic individuals were also as group. Blood samples from...