A5069528679- Cancer Mechanisms and Therapy
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Cell death mechanisms and regulation
- Neuroblastoma Research and Treatments
- Phagocytosis and Immune Regulation
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- X-ray Diffraction in Crystallography
- Melanoma and MAPK Pathways
- Microbial Metabolism and Applications
- Protein Tyrosine Phosphatases
- Extracellular vesicles in disease
- Synthesis and Biological Evaluation
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Protein Degradation and Inhibitors
Universidade Estadual de Maringá
2020-2024
Universidade Estadual de Campinas (UNICAMP)
2016-2021
Centro Universitário Cesumar
2021
Treatment of metastatic melanoma still remains a challenge, since in advanced stage it is refractory to conventional treatments. Most patients with have either B-RAF or N-RAS mutations, and these oncogenes lead activation the RAS-RAF-MEK-ERK AKT signal pathway, keeping active proliferation survival pathways cell. Therefore, identification small molecules that block cell induce death needed. Violacein, pigment produced by Chromobacterium violaceum found Amazon River, has been used our group...
ABSTRACT In chemoresistant leukemia cells (Lucena‐1), the low molecular weight protein tyrosine phosphatase (LMWPTP) is about 20‐fold more active than in their susceptible counterpart (K562). We found this ensures activated statuses of Src and Bcr‐Abl. Since, phosphorylation dephosphorylation proteins represent a key post‐translational regulation several enzymes, we also explored kinome. hereby show that LMWPTP superactivation, together with kinome reprogramming, cooperate towards glucose...
Melanoma is a type of skin cancer with low survival rates after it has metastasized. In order to find molecular differences that could represent targets quercetin in anti-melanoma activity, we have chosen SKMEL-103 and SKMEL-28 melanoma cells human melanocytes as models. Firstly, observed was able reducing cell viability, but not SKMEL-28. Besides that, treatment caused inhibition AXL both lines, upregulation PIM-1 downregulation SKMEL-103. Moreover, HIF-1 alpha expression decreased lines....
O entendimento da população acerca do câncer de pele pode ser decisivo para seu desfecho clínico, já que o mau prognóstico está associado ao avanço doença. objetivo deste estudo foi verificar conhecimento em ambiente universitário sobre as características e cuidados na prevenção pele. Trata-se um transversal realizado Maringá-PR, por questionário validado. Foram entrevistados 458 indivíduos, dos quais a maioria eram mulheres (62,01%), variando entre estudantes das áreas exatas, humanas ou...