A5033985755- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Organic Compounds
- Cancer therapeutics and mechanisms
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Biodiesel Production and Applications
- Chemical Reaction Mechanisms
- Molecular spectroscopy and chirality
- Petroleum Processing and Analysis
- Catalysis and Hydrodesulfurization Studies
- Inorganic and Organometallic Chemistry
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Morinda citrifolia extract uses
- Organic Chemistry Cycloaddition Reactions
- Lubricants and Their Additives
- Computational Drug Discovery Methods
Universidade Federal do Espírito Santo
2014-2024
Polish Academy of Learning
2022
Polish Academy of Sciences
2022
Sichuan University
2022
East China University of Technology
2022
University of Milan
2022
University of Bern
2022
Discovery Air (Canada)
2019
Laboratoire de Synthèse Organique
2015
Universidade Federal Fluminense
2002-2009
In this work, electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI(±)-FT-ICR MS) was applied in the chemical characterization of polar compounds. These compounds were identified as oxygen-containing compound classes (naphthenic acids, O2 class, and phenols, O1 class), sulfur-containing (mainly sulfides, S1 basic non-basic nitrogen-containing (carbazoles pyridines, N class). For access employed methylation reactions. As increasing distillation cut...
The essential oil (EO) composition of ripe fruit S. terebinthifolius Raddi was analyzed by GC-MS. extraction yielded 6.54 ± 1.06% (w/w). Seventeen compounds were identified, accounting for 91.15% the total oil, where monoterpenes constituted main chemical class (85.81%), followed sesquiterpenes (5.34%). major monoterpene identified δ-3-carene (30.37%), limonene (17.44%), α-phellandrene (12.60%) and α-pinene (12.59%). Trans-caryophyllene (1.77%) sesquiterpene identified. antibacterial...
Abstract This review summarizes the latest developments in asymmetric domino reactions, with emphasis on preparation of spiro compounds. Discussions stereoselectivity transformations, reaction mechanisms, rationalization stereochemical outcome, and applications reactions to synthesis biologically active molecules natural products are included when appropriate. 1 Introduction 2 Asymmetric Domino Reactions 2.1 Initiated by Michael 2.2 Mannich 2.3 Knoevenagel 2.4 Cycloaddition 2.5 Metal...
Abstract The enantioselective Povarov reaction is one of the most powerful synthetic strategy to synthesize chiral, highly functionalized 1,2,3,4‐tetrahydroquinolines. present Minireview aims collect significant successful examples efficient catalytic protocols for this reaction, since 2014. A comprehensive discussion different strategies employed in recent years realize provided; use chiral phosphoric acids, thio(urea) and proline derivatives, as well transition metal complexes will be...
A series of novel Mannich bases (HL1-HL13) derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes [C6H2R¹R²R³C(O)H] and various primary amines (NH2R4, R4 = n-butyl, benzyl, allyl, 2-furfuryl), their Cu2+ complexes, [Cu(L1)2]-[Cu(L13)2], have been synthesized fully characterized by analytical spectroscopic methods. The structures complexes 1(R¹ R² R³ H; Bu), 2(R¹ NO2; R4= Bu) 7 (R¹ OH; were determined single crystal X-ray diffraction studies. All crystallize in...
Eleven 2,3-(substituted)-1,4-naphthoquinone derivatives were synthesized in yields ranging from 52-89%.These evaluated for their cytotoxic effects on human lungs (H460), triple-negative breast (MDA-MB-231) and ovarian (A2780) cancer cell lines.Compounds 5f 8 showed IC 50 values of 3.048 × 10 -5 mol L -1 4.24 -6 H460; 5c 2.16 1.60 MDA-MB-231, 5g 2.68 3.89 A2780.Additionally, we conducted a docking study with the four most active compounds therapeutic targets PI3K topoisomerase II showing...
A esterificação direta de naftoquinonas mostrou-se uma tarefa difícil.Metodologias mais comuns envolvem a aplicação cloretos acila em piridina ou anidridos, entretanto, quando ácidos cadeia longa são utilizados tais metodologias se mostram ineficientes devido aos baixos rendimentos obtidos.Apresentamos nova síntese ésteres juglona baseado na Steglich utilizando um ácido Lewis barato como cocatalisador.Rendimentos obtidos consideravelmente maiores do que os reportados previamente.Química...
A new high photoluminescent metal–organic complex is proposed as an optical marker for the indentification of gunshot residues (GSR) produced from firearms. The containing Eu3 + ion was synthesized producing [Eu(PIC)3(NMK)3] complex, where PIC picric acid and NMK n-methyl caprolactam. It chemically characterized using emission spectroscopy, Fourier transform infrared thermogravimetric differential thermal analyses, electrospray ionization cyclotron resonance mass spectrometry (ESI-FT-ICR MS)...
In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride catalyst was developed for synthesis of spiro compounds. The reaction conditions considered ideal were determined from methodological study varying solvent, catalyst, amount temperature, heating mode. Finally, generality methodology evaluated by exploring scope reaction, starting materials (isatin, malononitrile,...
Environmentally friendly one-pot protocol was developed for the first synthesis of aminonaphthoquinones derived from 2-hydroxy-1,4-naphthoquinone (lawsone) via a multicomponent Mannich reaction in aqueous media using catalytic amount dodecyl benzenesulfonic acid (DBSA), exploring Brønsted acid-surfactant catalyst (BASC) concept, at room temperature.
Three molecular hybrids containing 1,4-naphthoquinones, 1,3,5-triazines, morpholine and 7-chloroquinoline, which have recognized contributions to the biological activity of many drugs, were synthesized in yields ranging from 43-84%.All obtained three steps starting readily available reactants: lawsone, cyanuric chloride, 4,7-dichloroquinoline.A previous docking study was carried out identify binding energy pharmacophore conformation promising anticancer compounds with PI3Kγ (phosphoinositide...
OILSEEDS BY LOW-FIELD NMR.To choose among the variety of oleaginous plants for biodiesel production, oil content several matrices was determined through different low-field 1 H nuclear magnetic resonance (NMR) experiments with varied pulse sequences, namely single-pulse, spin-echo, CPMG, and CWFP.The that involved first three sequences showed high correlation each other solvent extraction method.The quality vegetable oils also evaluated on basis existing between T 2 values their properties,...